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Cannabidiol Inhibits SARS-CoV-2 Replication and Promotes the Host Innate Immune Response (Preprint) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987002/ https://www.science.org/doi/10.1126/sciadv.abi6110 Cannabidiol (CBD) Potential regulator of the host stress and antiviral inflammatory responses (cannabinoid class of natural products) Hemp, cannabis plants, Less than 0.3% psychotropic tetrahydrocannabinol (THC) Oral solution of CBD is a U.S. FDA approved drug High-purity CBD inhibits SARS-CoV-2 replication in human lung epithelial cells Pretreated human lung cells (with ACE2 receptor) for 2 hours with CBD before infection with SARS-CoV-2. CBD potently inhibited viral replication under nontoxic conditions (no toxicity was observed at the effective doses) Worked in other human lung cell lines, worked in monkey kidney cells Tested on Wuhan strain and 3 VOCs Their ability to infect cells was comparably inhibited by CBD CBD or other cannabinoids? Checked 97 to 100% pure using quantitative nuclear magnetic resonance (qNMR). No toxicity was observed for any of the CBD preparations at the doses used to inhibit viral infection The CBD metabolite 7-OH-CBD, 7-hydroxy-cannabidiol exhibits antiviral activity Others did not work Combining CBD with THC (1:1) significantly suppressed CBD efficacy, consistent with competitive inhibition by THC. CBD and 7-OH-CBD metabolite are the active and equipotent ingredients for the treatment of epilepsy CBD acts at an early step after viral entry into cells CBD targets host cell processes. CBD inhibits viral RNA expression and reverses viral-induced changes in host gene expression CBD effectively eradicated viral RNA expression in the host cells Prevents changes in the cell produced by the virus to force the cell to produce new viral particles CBD induces strong activation of genes associated with the host stress response. Together, these results suggest that CBD acts to prevent viral protein translation and associated cellular changes. Induction of viral genes for spike, envelope, and nucleocapsid proteins is reduced ~99% with CBD CBD induction of increased transcription of 3 defensive endoplasmic reticulum genes CBD induces interferon expression as part of its antiviral activity CBD suppress viral infection, and promote degradation of viral RNA (SARS-CoV-2 infection suppresses the interferon signaling pathway) CBD sufficiently lowers the effective viral titer to enable normal host activation of the interferon pathway. CBD effectively reversed viral induction of cytokines that can lead to deadly cytokine storm CBD treatment significantly inhibits SARS-CoV-2 replication in mice After viral the challenge, administration of CBD continued twice daily for an additional 4 days CBD treatment significantly inhibited viral replication in lungs and nasal turbinates at day 5 after infection Lower dose of CBD reduced viral load by 4.8-fold in lungs Higher dose of CBD reduced viral load by 40 -fold in lungs During this period, the mice showed no signs of clinical disease These results establish the preclinical efficacy of CBD as an antiviral drug for SARS-CoV-2 during early stages of infection. CBD is negatively associated with indications of SARS-CoV-2 infection in patient medical records Given that high-purity CBD preparations are taken by a large number of individuals, we examined whether CBD prescriptions are associated with indications of SARS-CoV-2 infection An oral solution of CBD (100 mg/ml) (CBD100) is often used for the treatment of seizures Analysis of 1,212 patients Matched to control group counterparts 6.2% (75 patients) with CDB 8.9% for non-CBD patients (P = 0.014) Odds ratio (OR) of 0.65, (P = 0.009) Odds ratio (OR) of 0.48, (P = 0.006) Potential of Cannabidiol for the Treatment of Viral Hepatitis https://scholar.google.com/scholar_lookup?title=Potential+of+cannabidiol+for+the+treatment+of+viral+hepatitis&author=H.+I.+Lowe&author=N.+J.+Toyang&author=W.+McLaughlin&publication_year=2017&journal=Pharm.+Res.&pages=116-118 CBD inhibited HCV replication by 86.4% (Not Hep B) Other RNA viral infections Common cold Influenza SARS / MERS Dengue Hep C and E Ebola Rabies Polio Mumps Measles

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In this video, I go over the following topics: 1. The DEA's stance on Delta-8 and Delta-9-THCO 2. The 2018 Farm Bill 3. Cannabinoids: Naturally-occurring vs Synthetic vs Semisynthetic 4. Briefly how THC-O is linked to EVALI/Ketene formation If you want more updates like this, don’t forget to Like & Subscribe ;)! Products I have tried since the filming of this video: Hemp Love Farms - Check them out if you're interested! assorted flavors: https://amzn.to/42l9VDK Strawberry Banana: https://amzn.to/3ATQTsq Melon Berry: https://amzn.to/3NGuAhQ Pineapple: https://amzn.to/3NG07jS Grape: https://amzn.to/415FZKP Hemp Gummies: Watermelon OG: https://amzn.to/3LX3rWk Blue Razz: https://amzn.to/42JhsNd Tropical Punch: https://amzn.to/3nEcOAV Audio at 1:40 by @FILMCRUX What is Delta-8-THC? https://youtu.be/U94R0XEqDdo What is THC-O-Acetate? https://youtu.be/0TUTwjs7jK0 What is HHC? https://youtu.be/GakW41MNMEs Website with the DEA response letter: https://www.marijuanamoment.net/dea-classifies-novel-cannabinoids-delta-8-and-9-thco-as-controlled-substances-even-when-synthesized-from-legal-hemp/ Structure-Activity Relationship of Cannabis Derived Compounds for the Treatment of Neuronal Activity-Related Diseases: https://www.mdpi.com/1420-3049/ljdsg23/7/1526 CDC: https://www.cdc.gov/tobacco/basic_information/e-cigarettes/severe-lung-disease.html THC-O-Acetate Wikipedia: https://en.wikipedia.org/wiki/THC-O-acetate Vaping Cannabinoid Acetates Leads to Ketene Formation https://chemrxiv.org/engage/chemrxiv/article-details/627401c36cae1c94a5fe8fe7 !TIME STAMPS! 0:00 Introduction 1:00 THC-O Is Now A Controlled Substance 1:57 DEA Letter 3:11 2018 Farm Bill 3:37 Natural vs Synthetic Cannabinoids 3:48 Naturally Occurring Cannabinoids 4:00 Synthetic Cannabinoids 4:57 Semi-synthetic Cannabinoids 5:48 Vaping THC-O and Ketene Formation 6:08 Random THC-O Fact #420 #420daily #cannabinoids #cannabisdaily #cannabiseducation #cannabisheals #cannabispodcast #mmj #alternativemedicine #flower #florida #reddit #synthetic #syntheticcannabinoids #naturally #phyto #medicalcannabis #medicalmarijuana #medicalmarijuanapatient #medical #cbdforlife #healthylifestyle #health #healthy #wellness #yoga #news #govt #viral #weedzao #thecannabisdoc #thecannadoc #anthonyandreoni #andreoni #miami #broward #subscribe

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What is CBD Oil? CBD oil is an extract from the hemp plant. It's cannabis without the THC that causes delirium. CBD Oil is now being used to ease the symptoms of anxiety and helping some people sleep better at night.

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Happy Hemp CBD Gummies have been gaining popularity in the wellness world as a tasty and convenient way to incorporate the benefits of CBD into your daily routine. These gummies come in a variety of flavors and are designed to promote relaxation, reduce stress, and support overall well-being. In this article, we will take a closer look at the different flavors and effects of Happy Hemp CBD Gummies to help you decide if they are the right choice for you.

Flavors

Happy Hemp CBD Gummies are available in a range of delicious flavors to suit every taste preference. From fruity options like strawberry and watermelon to more unique choices like sour apple and peach rings, there is a flavor for everyone. Each gummy is infused with high-quality CBD isolate, ensuring consistent dosing and a pure CBD experience.

One of the most popular flavors of Happy Hemp CBD Gummies is the mixed fruit variety, which includes a mix of cherry, strawberry, orange, lemon, and grape gummies. These gummies are bursting with flavor and provide a fun and tasty way to enjoy the benefits of CBD. The mixed fruit gummies are perfect for those who like a little variety in their CBD snacks.

If you’re a fan of sour candies, you’ll love the sour apple and peach ring flavors of Happy Hemp CBD Gummies. These tangy gummies pack a flavorful punch while delivering the calming effects of CBD. The sour apple and peach ring gummies are a great option for those looking for a more intense flavor experience.

Effects

Happy Hemp CBD Gummies are designed to promote relaxation and reduce stress, making them a great option for those looking for natural ways to unwind after a long day. The CBD isolate used in these gummies is known for its calming properties, helping to soothe both the mind and body. Many users report feeling a sense of calm and tranquility after taking Happy Hemp CBD Gummies.

In addition to promoting relaxation, Happy Hemp CBD Gummies may also help to alleviate symptoms of anxiety and improve mood. CBD has been shown to interact with the body’s endocannabinoid system, which plays a role in regulating mood and stress responses. By supporting the endocannabinoid system, CBD may help to promote a sense of well-being and positivity.

Some users of Happy Hemp CBD Gummies also report experiencing better sleep quality and relief from insomnia. CBD has been studied for its potential to improve sleep patterns and promote restful sleep. By taking a gummy before bedtime, you may find it easier to relax and drift off to sleep peacefully.

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Summary

In conclusion, Happy Hemp CBD Gummies are a delicious and effective way to incorporate the benefits of CBD into your daily routine. With a variety of flavors to choose from, there is a gummy for everyone. Whether you’re looking to relax, reduce stress, or improve sleep quality, Happy Hemp CBD Gummies may be the perfect solution for you. Give them a try and experience the calming effects of CBD for yourself.

If you have any questions or concerns about Happy Hemp CBD Gummies, check out our FAQ section below for more information.

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The countdown to the 2020 harvest is on! If you are a farmer you know what that means... Harvest side effects include: -Sleepless nights -Crop nightmares -Crippling anxiety -Compulsive news weather watching -A permanent hemp smell on everything you own -Repeatedly chanting, “is this worth it?” Thankfully we grow a beautiful plant that helps with 3 out of 6 of those problems! For the other half of the list we have for you a "Buchanan’s Pineapple Cranberry CBD Cocktail." This is an incredibly easy drink that we made using ingredients we had on hand! (Unfortunately, we didn’t have any Buchanan Scotch so we did make a switch to Johnnie Walker.) Check out our blog for more recipes and Schoppee Farm updates! https://shopschoppee.com/blogs/sf-blog

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