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Cannabis is a well known drug which is known to alter the mind and body. It is also known as “pot”, “weed”, “ganja”, “marijuana” and many other slang terms. In this video, we have provided details on the composition of cannabis, its short and long term effects on brain and body, its advantages and disadvantages in medical and recreational, and its effect on individuals with different mental disorders. The video is intended to educate the general public about cannabis use and its effects. It is not intended to harm anyone’s emotions who is currently dealing with cannabis use problems. It is advised to contact a healthcare provider in case you are experiencing any symptoms or have additional concerns. ------------------------------------ This video was made by McMaster students Shefali Verma, Shilpa Tandon, and Niki Sadat Afjeh in collaboration with the McMaster Demystifying Medicine Program. Subscribe to the McMaster Demystifying Medicine YouTube channel: https://www.youtube.com/c/DemystifyingMedicine This video is provided for general and educational information only. Please consult your health care provider for Information about your health. ------------------------------------ Copyright McMaster University 2020 ------------------------------------ #DemystifyingMedicine, #MentalHealth References: 1. Gibbs, M., Winsper, C., Marwaha, S., Gilbert, E., Broome, M., & Singh, S. P. (2015). Cannabis use and mania symptoms: a systematic review and meta-analysis. Journal of affective disorders, 171, 39–47. https://doi.org/10.1016/j.jad.2014.09.016 2. Grinspoon, Peter. “Medical Marijuana.” Harvard Health Blog, 15 Apr. 2020, www.health.harvard.edu/blog/medical-marijuana-2018011513085. 3. Hall, W., & Solowij, N. (1998). Adverse effects of cannabis. The Lancet, 352(9140), 1611-1616. Hartman, R. L., & Huestis, M. A. (2013). Cannabis effects on driving skills. Clinical chemistry, 59(3), 478–492. https://doi.org/10.1373/clinchem.2012.194381 4. Hunt, G. E., Malhi, G. S., Cleary, M., Lai, H. M., & Sitharthan, T. (2016). Prevalence of comorbid bipolar and substance use disorders in clinical settings, 1990-2015: Systematic review and meta-analysis. Journal of affective disorders, 206, 331–349. https://doi.org/10.1016/j.jad.2016.07.011 5. Kedzior, K. K., & Laeber, L. T. (2014). A positive association between anxiety disorders and cannabis use or cannabis use disorders in the general population--a meta-analysis of 31 studies. BMC psychiatry, 14, 136. https://doi.org/10.1186/1471-244X-14-136 6. Lev-Ran, S., Roerecke, M., Le Foll, B., George, T., McKenzie, K., & Rehm, J. (2014). The association between cannabis use and depression: A systematic review and meta-analysis of longitudinal studies. Psychological Medicine, 44(4), 797-810. doi:10.1017/S0033291713001438 7. Lloyd, S. L., & Striley, C. W. (2018). Marijuana Use Among Adults 50 Years or Older in the 21st Century. Gerontology & geriatric medicine, 4, 2333721418781668. https://doi.org/10.1177/2333721418781668 8. Mönckeberg B F. (2014). Los pro y contra de la legalización de la marihuana [Pros and cons of legalizing marijuana]. Revista chilena de pediatria, 85(2), 229–237. https://doi.org/10.4067/S0370-41062014000200014 9. NIDA. 2020, April 8. Is marijuana a gateway drug?. Retrieved from https://www.drugabuse.gov/publications/research-reports/marijuana/marijuana-gateway-drug on 2020, November 15 10. Regier, D. A., Farmer, M. E., Rae, D. S., Locke, B. Z., Keith, S. J., Judd, L. L., & Goodwin, F. K. (1990). Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) Study. JAMA, 264(19), 2511–2518. 11. Statista. “Marijuana Consumption by Age Canada 2019.” Statista, 2 Sept. 2020, www.statista.com/statistics/587705/marijuana-consumption-canada-by-age/. 12. Shrivastava, A., Johnston, M., Terpstra, K., & Bureau, Y. (2014). Cannabis and psychosis: Neurobiology. Indian journal of psychiatry, 56( 1), 8–16. https://doi.org/10.4103/0019-5545.124708 13. The Ministry of Health. “Health Effects of Cannabis.” Government of Canada, 2017, www.canada.ca/content/dam/hc-sc/documents/services/campaigns/27-16-1808-Factsheet-Health- Effects-eng-web.pdf.

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Introduction

Cannabidiol (CBD) and cannabigerol (CBG) are two prominent cannabinoids derived from the cannabis plant, both of which have gained attention for their therapeutic potential. With growing interest in alternative treatments for pain and inflammation, individuals are looking towards these natural compounds as viable options. Understanding the nuanced differences between CBD and CBG is crucial for anyone considering their use for relief from pain and inflammation. Both cannabinoids interact with the body’s endocannabinoid system but in unique ways that can influence their effectiveness and benefits. One might wonder: What sets CBD apart from CBG? How do these compounds compare when it comes to alleviating pain and inflammation?

CBD is well-known for its wide range of therapeutic effects, such as anti-inflammatory, analgesic, and anxiety-reducing properties. These benefits have led to increased usage in various forms, including oils, topical creams, and edibles. It’s often the first cannabinoid that comes to mind for those seeking relief from chronic pain or inflammation-related conditions. On the other hand, CBG is often regarded as the “mother” cannabinoid, as it is the precursor to other cannabinoids, including CBD and THC. Research into CBG is still evolving, but early studies suggest it may offer similar, if not distinct therapeutic benefits, particularly for inflammation-related conditions.

The pharmacological effects of cannabinoids can vary significantly due to their distinct molecular structures and how they interact with the body’s cannabinoid receptors. In the case of pain and inflammation relief, cannabinoid receptor agonism or antagonism may result in different outcomes depending on the specific compound. The way these cannabinoids are extracted, their concentrations, and how they are consumed can also play critical roles in their effectiveness. Furthermore, while both cannabinoids are generally well-tolerated, they may exhibit different side effect profiles, which could impact user experiences.

As research and anecdotal evidence continue to surface, there’s a rising emphasis on understanding not just how CBD and CBG work but also the potential for combining them for an enhanced therapeutic effect. Knowing the differences and similarities between these two cannabinoids is vital for consumers, healthcare professionals, and researchers alike. As such, this article will explore five essential differences between CBD and CBG, focusing specifically on their implications for pain and inflammation relief. By delving into these differences, readers can make informed choices regarding which cannabinoid may be most effective for their individual needs, ultimately empowering them in their wellness journey.

Biochemical Structure and Properties

The first key difference between CBD and CBG lies in their biochemical structure. CBD is a non-psychoactive cannabinoid composed of 21 carbon atoms, 30 hydrogen atoms, and 2 oxygen atoms, which gives it unique properties and allows it to engage with the endocannabinoid system (ECS) effectively. This structure enables CBD to bind particularly well to CB2 receptors, which are primarily associated with anti-inflammatory responses. CBG, however, has a slightly different molecular structure with a different arrangement of atoms; it is also composed of 21 carbon atoms but includes 32 hydrogen atoms and 2 oxygen atoms. This structural variance allows CBG to target different receptors within the ECS, potentially leading to distinct therapeutic effects.

The variance in structure also affects how each cannabinoid interacts with various enzymes and compounds within the body. For example, CBD has been shown to inhibit the breakdown of anandamide, an endocannabinoid known for its pain-relieving effects. By increasing the levels of anandamide, CBD contributes to pain relief and anti-inflammatory properties. Conversely, preliminary studies suggest that CBG may promote the inhibition of certain inflammatory markers through its interaction with specific receptors, leading to effective pain management. These differing mechanisms highlight the importance of targeting specific pain pathways depending on which cannabinoid is being used.

Additionally, the bioavailability of CBD and CBG can influence how effectively the body utilizes these cannabinoids. Factors such as the method of consumption—be it oil, capsule, or topical—and the individual’s metabolism can significantly impact bioavailability. While both cannabinoids can be administered in various forms, understanding the biochemical makeup is essential for optimizing their use for pain management. Each cannabinoid brings forth unique qualities, making it necessary to consider these biochemical characteristics when choosing between CBD and CBG for specific health challenges or therapeutic goals.

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Cannabinoid Effects on Pain Management

Pain management is one of the most extensively researched applications of cannabinoids, and both CBD and CBG exhibit pain-relieving properties, albeit through different mechanisms. CBD is primarily acknowledged for its analgesic effects, which are often attributed to its ability to reduce inflammation and interact effectively with CB2 receptors. Various studies have suggested that CBD can be beneficial for conditions such as arthritis, multiple sclerosis, and chronic pain syndromes. By mitigating inflammation and enhancing the body’s pain threshold, CBD serves as an effective option for those seeking relief from chronic pain.

Conversely, CBG’s role in pain management is less understood but equally intriguing. Research indicates that CBG may reduce inflammation and pain by modulating the sensitivity of pain receptors in the nervous system. It appears to also have anti-inflammatory effects that may offer a complementary approach to pain relief. This is particularly promising for inflammatory conditions like inflammatory bowel disease (IBD), where existing studies suggest significant improvements in symptoms following CBG administration. Both cannabinoids may offer positive attributes, yet their core differences can influence which option may be more appropriate for a specific pain condition.

Another crucial aspect to consider is the potential entourage effect that occurs when cannabinoids, terpenes, and other compounds are consumed together. This phenomenon suggests that the therapeutic effects of cannabinoids may be enhanced when they work in conjunction with one another. Employing combinations of CBD and CBG could provide a more rounded approach to pain management by leveraging the unique attributes of both cannabinoids. By recognizing the distinct pathways through which these cannabinoids operate, individuals can make informed choices tailored to their specific pain management needs and overall health objectives.

Therapeutic Applications and Benefits

The therapeutic applications of CBD and CBG extend beyond pain relief and inflammation management. CBD is often recognized for its versatility in addressing a range of ailments, such as anxiety, depression, sleep disorders, and even epilepsy. The anti-anxiety properties of CBD can offer an overall sense of well-being, which may contribute positively to pain and inflammation by reducing stress, a known exacerbator of these conditions. Furthermore, its neuroprotective effects have implications for individuals suffering from neurodegenerative diseases and conditions impacting cognitive function.

CBG shows promise as well, particularly in areas where CBD may be less effective. For instance, early research has indicated that CBG exhibits antimicrobial properties, which could make it beneficial for conditions where bacterial infections complicate pain and inflammation. It may also play a role in promoting appetite and has been studied for its potential neuroprotective effects. These therapeutic benefits further differentiate CBG from CBD, showcasing its unique potential in treating specific health issues that may accompany or exacerbate pain and inflammation.

In terms of application, both compounds can be utilized in various formats—oils, capsules, edibles, topicals—based on individual preferences and conditions. The way these products are formulated can significantly influence their effectiveness. For example, a topical cream containing both CBD and CBG may be particularly beneficial for localized pain and inflammation, as it allows for direct application to the affected area. The flexibility in therapeutic applications is one of the defining advantages of both cannabinoids, permitting patients to tailor their approach to treatment based on their needs and lifestyle.

Side Effects and Safety Profiles

With any therapeutic substance, understanding the side effects and safety profiles is paramount, especially when considering the long-term use of cannabinoids like CBD and CBG. Generally speaking, both cannabinoids are regarded as well-tolerated, but they are not entirely without their potential side effects. CBD users have occasionally reported experiences of dizziness, dry mouth, or fatigue, especially at higher dosages. Importantly, CBD can interact with other medications, particularly those processed by the liver, emphasizing the need for consultation with healthcare professionals before starting a regimen.

CBG, being relatively newer to the mainstream health conversation, may present fewer known side effects, but data is limited regarding its long-term safety. Initial reports suggest similar mild side effects as CBD, with some users experiencing slight changes in appetite or mood. Given that CBG may interact with different serotonin receptors, its safety and efficacy will require more extensive research. Moreover, users considering CBG should always be aware of potential interactions with medications, especially those targeting mood and appetite.

When navigating the world of cannabinoids, consumers must prioritize sources and formulations that uphold safety and transparency. Third-party testing and clear labeling can provide critical information regarding cannabinoid concentrations and purity, ensuring that individuals can trust what they consume. In making informed decisions about using CBD or CBG, understanding the safety and side effect profiles of cannabinoids becomes a critical aspect, ensuring utmost wellness and minimizing risks associated with their use.

Summary and Common Questions

As we draw our exploration of CBD and CBG to a close, it’s crucial to summarize the insights gleaned regarding their differences and therapeutic implications for pain and inflammation relief. Both cannabinoids exhibit unique biochemical structures and mechanisms of action, affecting how they interact with the body’s endocannabinoid system. CBD, known primarily for its analgesic effects, works effectively via its interaction with CB2 receptors, while CBG offers promising alternatives that may provide varying kinds of relief through its anti-inflammatory properties.

When considering their applications, both CBD and CBG have far-reaching therapeutic potential, extending beyond just pain management. They may address a host of health issues, including anxiety, sleep disorders, and even neurodegenerative conditions. However, consumer awareness is essential, particularly regarding potential side effects and the necessity for responsible sourcing and formulation practices.

A frequently asked question surrounds the legality of these cannabinoids. As regulations can vary significantly from one region to another, it’s imperative for users to research local laws regarding the possession and use of CBD and CBG products. Another common inquiry involves their use in conjunction; the emerging concept of the entourage effect suggests that combining CBD and CBG may enhance their therapeutic outcomes. Lastly, dosage recommendations can vary, and individuals are advised to start low and gradually increase as needed while monitoring their body’s response.

Ultimately, whether one chooses CBD, CBG, or a combination of both, being well-informed and consulting healthcare professionals when needed will help guide successful usage for pain and inflammation relief. The landscape of cannabinoid therapies is continually evolving, and both CBD and CBG stand at the forefront of this natural approach to wellness.