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This is an 18+ Adult Cannabis Channel! Welcome to The HotBox!!! Today we are answering the question ourselves, does Delta 8 get you high?💨 We had a good time trying out a few different kinds of products while getting faded in the process💯🙏 Hope you enjoy this video. Make sure to Like & Subscribe for more! SUPPORT US!!! Follow us on Instagram! @thehotbox.ig Link: https://www.instagram.com/thehotbox.ig Check out our Twitch! @thehotbox710 Link: https://www.twitch.tv/thehotbox710 WE GOT MERCH!!! Link: https://thehotbox.creator-spring.com/ Support us on PATREON if you want!! Link: https://www.patreon.com/thehotbox VIDEOS!!! Watch our Gas Mask Bong Rips video!!! Link: https://www.youtube.com/watch?v=HL0FFKBvEoc&t We went on a hike while high!!! (Vlog) Link: https://www.youtube.com/watch?v=O8fHgkIMvog&t #Delta8 #Hotbox We hope everyone watching has a great vibe!!

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While kratom is legal and natural, a chemically altered form of it is causing worry for doctors and parents across the country.

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Scientists have shown that an active ingredient of cannabis significantly upregulates autophagy, extending both lifespan and healthspan in C. elegans nematode worms and demonstrating benefits to mouse neurons. Two of the most well-known components of marijuana are tetrahydrocannabinol, or THC, and cannabidiol, or CBD. They have the same atomic composition, but differ in structure. THC provides the high that is often associated with marijuana use. CBD, on the other hand, is considered benign and seems to possess antipsychotic, pro-cognitive, anti-inflammatory, anti-seizure, and antioxidant properties. In June 2018, the FDA approved Epidiolex, the first CBD-based prescription medication, for rare forms of epilepsy, and later for the treatment of some seizures. However, the research into both compounds is still in its infancy. In this new study, scientists dived deeper into the workings of CBD using C. elegans nematode worms, which is considered a good model for initial studies, including in geroscience. Previous research has shown that CBD can increase lifespan in C. elegans and zebrafish, but the mechanism had remained unknown. Another study found that CBD induces autophagy in cultured neuronal cells. In this new study, the researchers attempted to investigate the relationship between these two effects. Autophagy is the process of clearing away various cellular debris, such as misfolded proteins and dysfunctional organelles. Unsurprisingly, this maintenance system appears to be very important for health and longevity in numerous model organisms and in humans. The CBD treatment greatly increased autophagic activity in several tissues and cell types, most drastically by 78% in neurons. The researchers then validated those findings in vitro on several types of cells, including mouse primary hippocampal neurons. Importantly, impaired autophagy in the brain is considered a major cause of Alzheimer’s disease. Worms on CBD lived significantly longer than controls. The researchers also measured the worms’ healthspan. Many interventions that prolong lifespan in C. elegans often lead to functional impairment, such as decreased motility. Three popular health metrics in C. elegans that decline with age are pharyngeal pumping rate, reproductive capacity, and locomotion, and all three were significantly restored, rather than impaired, by CBD treatment. The gene SIRT1 has been a popular object of study in geroscience. One of its roles is a mediator of autophagy. By knocking out SIRT1 in mouse neurons, researchers were able to obliterate many of the benefits of CBD, pointing at a crucial role of SIRT1 in mediating CBD-induced effects. This study expands our understanding of CBD's effects, linking them to autophagy, an important process that keeps popping up on geroscientists' radars. It is encouraging that CBD demonstrates the strongest pro-autophagy effect in neurons, making it a potential anti-Alzheimer’s drug. Obviously, the fact that CBD increases autophagy in worms does not mean that using marijuana makes humans healthier, and we’ll need to see human trials on CBD and other compounds. SOURCES AND FURTHER READING ⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺ Cannabidiol induces autophagy and improves neuronal health associated with SIRT1 mediated longevity - https://pubmed.ncbi.nlm.nih.gov/35445360/ Effect of Cannabidiol on the Long-Term Toxicity and Lifespan in the Preclinical Model Caenorhabditis elegans - https://pubmed.ncbi.nlm.nih.gov/33998871/ Developmental exposure to cannabidiol (CBD) alters longevity and health span of zebrafish (Danio rerio) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205952/ Cannabidiol induces autophagy via ERK1/2 activation in neural cells - https://www.nature.com/articles/s41598-021-84879-2 EPIDIOLEX - https://youtu.be/zepKBzlKzdY FOOTAGE, IMAGES, AND MUSIC CREDITS ⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺ Stock footage & Images : Videoblocks.com, Shutterstock.com Music: "Elastic Vibe" by Ziv Moran PRODUCTION CREDITS ⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺ Host, Producer, & Editor - Ryan O’Shea Writer - Arkadi Mazin Art - Mattijs Vonk, Tim Maupin Executive Producer - Keith Comito #CBD #Science #Longevity

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https://www.facebook.com/PlantofRenown?ref=hl http://www.plantofrenown.com/ Pastors are going to be apologizing soon too! YES, I am a biblical believer and I said that! I have a friend who was a pastor for 15 yrs that's using the oil to heal a family member as we speak. By DESIGN YHVH put the endocannabinoid system in us, it is the most important and powerful system in our bodies, it maintains homeostasis down to a cellular level through our whole bodies and was not discovered until 1980's. The devil cannot put that in us, YHVH did. YHVH, by DESIGN gave us more cannabinoid receptors in us then any other and the majority are in our (((lungs)))), the devil cannot put those in us. Question, how are things absorbed through the lungs ( dont let your head pop,lol)? By DESIGN YHVH made CANNABINOIDS, they aggressively seek out mutated and cancer cells and cause apoptosis in them, they eat themselves, while leaving healthy cells alone and protecting our organs. The devil is not able to make those. Cannabinoids are only found in 2 places 1. Mothers breast milk=the cannabinoids strengthen babies immune system and ECS, along with making them hungry=they get the munchies. 2. THE CANNABIS PLANT. Our bodies and this plant by DESIGN were made to work together, proof of this is the endocannabinoid system, hello!!!Using this plant to heal yourself IS NOT sorcery, there has never been a single death from cannabis, its less addictive then caffeine, they don't have a single case of lung disease found in anyone that smokes just cannabis (different type of smoke then ciggs), its NOT the stepping stone or gateway drug alcohol is, its the gateway to HEALTH!!! ~Brad Mossman, Plant of Renown

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Organna CBD Gummies Review – Legit Or Scam? FIND OUT! Better sleep? Less anxiety? Sharper focus—all from one CBD gummy? Organna says yes. With buzzwords like “Delta-9,” “lab-tested,” and even claims of UC Davis medical collaboration, Organna CBD Gummies sound like a dream come true. But is it all hype? In this video, we break down the reality behind Organna’s claims: 🧪 The truth about their 92% satisfaction stat and “clinical” backing ⚠️ Hidden subscription traps and fine-print auto-renewals 💸 Why their “money-back guarantee” might not be what it seems 📉 No Trustpilot, no Reddit buzz, and suspicious marketing channels 🔍 Red flags that could cost you more than you expected Before you fall for another trendy wellness brand, watch this review first. 👇 Tried Organna or a similar CBD brand? Share your story in the comments. 👍 Like this video if it helped. 🔔 Subscribe for more honest product breakdowns and scam alerts. Keywords: organna cbd gummies, organna cbd gummies us, organna cbd gummies price, organna cbd gummies review, organna cbd gummies reviews, organa cbd gummies, organna cbd gummies real or fake, organa cbd gummies scam, organ cbd gummies, organa cbd gummies legit, organna cbd gummies dr anthony fauci, organa cbd gummies review, is organa cbd gummies scam, organa cbd gummies reviews, is organa cbd gummies legit, organa cbd gummies legit reddit, how does organa cbd gummies work, is organa cbd gummies scam or legit #organnacbdgummies #organnacbdgummiesScam #OrgannaCbdGummiesLegit #organnacbdgummies #organnacbdgummiesFake #organnacbdgummiesReddit #honestcheck Copyright Disclaimer: This video is for educational and informational purposes only. All opinions expressed are based on research and customer reports. Under Section 107 of the Copyright Act 1976, fair use is permitted for criticism, comment, news reporting, teaching, scholarship, and research.