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The Science behind Marijuana (Cannabis), Marijuana mechanism of action. Source of information: National Institute on Drug Abuse; National Institutes of Health; U.S. Department of Health and Human Services. Purchase a license to download a non-watermarked version of this video on AlilaMedicalMedia(dot)com Check out our new Alila Academy - AlilaAcademy(dot)com - complete video courses with quizzes, PDFs, and downloadable images. Voice by: Sue Stern Animation ©Alila Medical Media. All rights reserved. Marijuana, also known as cannabis, among other names, is a preparation of the Cannabis sativa plant - the hemp plant, intended for recreational and medicinal uses. The main psychoactive chemical in marijuana is delta-9-tetrahydro-cannabinol, or THC. The Cannabis plant preparation also contains other compounds that are chemically related to THC, called cannabinoids. THC is chemically similar to a class of substances found naturally in our nervous system called endogenous cannabinoids, or endocannabinoids, of which anandamide is best known so far. The endocannabinoids are part of a newly discovered system named the Endocannabinoid system, or ECS. How the ECS works The ECS acts as a modulator of neurotransmission. When the postsynaptic neuron is activated, endocannabinoids are produced, released, and travel back to the presynaptic neuron where they activate cannabinoid receptors. By doing so, they control what happens next when the presynaptic cell is again stimulated. The general effect is a decrease in the release of neurotransmitters such as GABA or glutamate. In other words, the ECS acts as a “brake”, slowing down neuronal activities, preventing neurons from excessive firing. Some examples of ECS functions include: - Pain modulation: cannabinoids suppress pain signal processing, producing pain relief effects. - Stress and anxiety reduction: The ECS has been implicated in the habituation the body’s response to repeated exposure to restraint stress. - Mood regulation: the ECS promotes “good feeling” by inducing dopamine release in the brain reward pathway. This explains the euphoria, or the “high”, experienced by marijuana users. THC mode of action is however different from other drugs: it induces dopamine release INDIRECTLY by removing inhibitory action of GABA on dopaminergic neurons. The ECS is also involved in many more bodily activities, including appetite, memory, learning, sleeping patterns, immune functions and fertility. So how can marijuana be harmful if it does exactly what our body already does to itself? The endocannabinoids are short-acting transmitter substances. They are synthesized on demand and their signaling is rapidly terminated by specific enzymes. Marijuana users consume a much higher amount of THC. THC is also much more stable and can persist in the body for a longer period of time. THC overwhelms the EC system, overriding normal brain functions. Because cannabinoid receptors are present in many parts of the brain and body, the effects of THC are wide-ranging. It can slow down a person’s reaction time, which could impair driving or athletic skills; disrupt short-term memory and higher thought processes, which could affect learning capabilities and judgment ability. Higher doses of THC may also lead to reverse effects. Consuming marijuana by smoking may also damage the lungs to a similar extent as smoking cigarettes. Long - term effects of THC Substantial evidence from animal research indicates that marijuana exposure can cause long-term adverse changes in the brain. Long-term effects of marijuana in human are still debatable mostly due to difficulties of conducting research in human beings. Medical uses of marijuana While recreational use of marijuana is without doubt harmful, the Cannabis plant may be a valuable source of medicines. Currently, the two main cannabinoids from the marijuana plant that are of medical interest are THC and cannabidiol, or CBD. These chemicals are used to increase appetite and reduce nausea in patients undergoing cancer chemotherapy. They may also be useful in reducing pain and inflammation, controlling epileptic seizures, and possibly even treating autoimmune diseases and cancers.

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What's up Buds, I'm sure a lot of you already have heard about THC, and maybe even delta-9 THC but have you heard of delta-8 THC? Just a few months ago I started seeing delta 8 articles pop up everywhere and slowly I started see brands producing delta-8 rich products like vapes and tinctures. I was intrigued because being the cannabis nerd I am, I had never heard of delta-8 so naturally I spent 4-6 hours researching up on it, and trying to get a better understanding of this minor cannabinoid. I made this video as short and sweet as I could so hopefully it's easy to take in and understand. Let me know in the comments if you have tried delta-8 THC and if you have what did you think of it? There is still so much than needs to be researched as far as cannabis goes but I truly believe there are so many benefits we have yet to find out about. Check out more educational videos on my channel Have a fantastic day, love y'all for FREE! FOLLOW ME BEYOND | INSTAGRAM | https://www.instagram.com/beyondthebuds/ | Beyond The Bud MERCH SHOP W/US | https://beyondthebud.kincustom.com/?_ga=2.166046653.242006312.1595195061-807295432.1570497606 | EVERYTHING ELSE | https://linktr.ee/Beyondthebud

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In this episode, I respond to recent research indicating there may be a role for Hemp CBD oil in the treatment of inflammation. This has implications for the management of conditions in which inflammation is often a contributing factor, such as Alzheimer's, depression, and chronic pain. Throughout this episode, I use the term "hemp" to refer to non-psychoactive strains of cannabis and the term "marijuana" to refer to psychoactive strains of cannabis. However, some people in the cannabis community feel the term "marijuana" is pejorative and have asked me not to use it. They prefer the general scientific term "cannabis", even though this term fails to distinguish between psychoactive and non-psychoactive strains. For clarity then, the preferred terminology is now Cannabis vs. Hemp CBD. The marketplace has adopted this convention and I will too. Bottom line, if you want to avoid psychoactive compounds like THC, just shop for Hemp CBD. Confusion over. Thank you for your feedback. P.S. To learn more about my own story of CBD and chronic pain click here: http://bioflourish.com/cbd-oil-and-lyme-disease/

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