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Cannabidiol Inhibits SARS-CoV-2 Replication and Promotes the Host Innate Immune Response (Preprint) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987002/ https://www.science.org/doi/10.1126/sciadv.abi6110 Cannabidiol (CBD) Potential regulator of the host stress and antiviral inflammatory responses (cannabinoid class of natural products) Hemp, cannabis plants, Less than 0.3% psychotropic tetrahydrocannabinol (THC) Oral solution of CBD is a U.S. FDA approved drug High-purity CBD inhibits SARS-CoV-2 replication in human lung epithelial cells Pretreated human lung cells (with ACE2 receptor) for 2 hours with CBD before infection with SARS-CoV-2. CBD potently inhibited viral replication under nontoxic conditions (no toxicity was observed at the effective doses) Worked in other human lung cell lines, worked in monkey kidney cells Tested on Wuhan strain and 3 VOCs Their ability to infect cells was comparably inhibited by CBD CBD or other cannabinoids? Checked 97 to 100% pure using quantitative nuclear magnetic resonance (qNMR). No toxicity was observed for any of the CBD preparations at the doses used to inhibit viral infection The CBD metabolite 7-OH-CBD, 7-hydroxy-cannabidiol exhibits antiviral activity Others did not work Combining CBD with THC (1:1) significantly suppressed CBD efficacy, consistent with competitive inhibition by THC. CBD and 7-OH-CBD metabolite are the active and equipotent ingredients for the treatment of epilepsy CBD acts at an early step after viral entry into cells CBD targets host cell processes. CBD inhibits viral RNA expression and reverses viral-induced changes in host gene expression CBD effectively eradicated viral RNA expression in the host cells Prevents changes in the cell produced by the virus to force the cell to produce new viral particles CBD induces strong activation of genes associated with the host stress response. Together, these results suggest that CBD acts to prevent viral protein translation and associated cellular changes. Induction of viral genes for spike, envelope, and nucleocapsid proteins is reduced ~99% with CBD CBD induction of increased transcription of 3 defensive endoplasmic reticulum genes CBD induces interferon expression as part of its antiviral activity CBD suppress viral infection, and promote degradation of viral RNA (SARS-CoV-2 infection suppresses the interferon signaling pathway) CBD sufficiently lowers the effective viral titer to enable normal host activation of the interferon pathway. CBD effectively reversed viral induction of cytokines that can lead to deadly cytokine storm CBD treatment significantly inhibits SARS-CoV-2 replication in mice After viral the challenge, administration of CBD continued twice daily for an additional 4 days CBD treatment significantly inhibited viral replication in lungs and nasal turbinates at day 5 after infection Lower dose of CBD reduced viral load by 4.8-fold in lungs Higher dose of CBD reduced viral load by 40 -fold in lungs During this period, the mice showed no signs of clinical disease These results establish the preclinical efficacy of CBD as an antiviral drug for SARS-CoV-2 during early stages of infection. CBD is negatively associated with indications of SARS-CoV-2 infection in patient medical records Given that high-purity CBD preparations are taken by a large number of individuals, we examined whether CBD prescriptions are associated with indications of SARS-CoV-2 infection An oral solution of CBD (100 mg/ml) (CBD100) is often used for the treatment of seizures Analysis of 1,212 patients Matched to control group counterparts 6.2% (75 patients) with CDB 8.9% for non-CBD patients (P = 0.014) Odds ratio (OR) of 0.65, (P = 0.009) Odds ratio (OR) of 0.48, (P = 0.006) Potential of Cannabidiol for the Treatment of Viral Hepatitis https://scholar.google.com/scholar_lookup?title=Potential+of+cannabidiol+for+the+treatment+of+viral+hepatitis&author=H.+I.+Lowe&author=N.+J.+Toyang&author=W.+McLaughlin&publication_year=2017&journal=Pharm.+Res.&pages=116-118 CBD inhibited HCV replication by 86.4% (Not Hep B) Other RNA viral infections Common cold Influenza SARS / MERS Dengue Hep C and E Ebola Rabies Polio Mumps Measles

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Understanding CBD Gummies

CBD, short for cannabidiol, has gained significant popularity as a natural remedy for various ailments. Derived from the hemp plant, CBD is non-intoxicating, meaning it does not produce the ‘high’ associated with THC, another well-known compound found in cannabis. One of the most convenient and enjoyable ways to consume CBD is through gummies. These delectable treats provide a discreet, flavorful, and easy method to integrate CBD into your daily routine. The growing interest in CBD gummies can be attributed to their health benefits, ease of use, and the fun factor of taking a gummy over a tincture or capsule.

CBD gummies come in various flavors, shapes, and concentrations, making them appealing to a wide range of consumers. Whether you are a seasoned CBD user or someone just exploring its benefits, the variety of choices means you can find CBD gummies that suit your taste and dosage preferences. It’s essential to identify high-quality gummies from reputable companies. This not only ensures you are consuming safe products but also maximizes the potential health benefits associated with CBD.

Shopping for CBD gummies online has become increasingly popular due to the convenience it offers. However, navigating the online marketplace can be challenging, especially with the rise of many companies offering CBD products. Factors such as quality, lab testing, and customer reviews play critical roles in determining where to buy. The five sellers discussed in the following sections are recognized for their commitment to quality and integrity, offering consumers a reliable starting point in the expansive world of CBD products.

Exhale Wellness: A Commitment to Quality

Exhale Wellness has established itself as a leading brand in the CBD industry, focusing on delivering high-quality products made from organically grown hemp. Their CBD gummies are crafted with care, ensuring that each gummy is packed with the full spectrum of beneficial cannabinoids. This company employs a unique CO2 extraction process, which is widely considered the gold standard in preserving the natural properties of the hemp plant while eliminating harmful chemicals.

One of the standout features of Exhale Wellness CBD gummies is their alignment with natural ingredients. Free from artificial colors and preservatives, these gummies are vegan and non-GMO. The flavors are derived from organic fruits, which not only makes them taste delicious but also assures that consumers are not ingesting harmful additives. Additionally, each batch of gummies undergoes third-party lab testing, providing transparency and assurance regarding the potency and purity of their products.

Customer feedback further solidifies Exhale Wellness’s reputation as a trusted brand. Many users report significant improvements in stress, anxiety levels, and overall wellness after incorporating these gummies into their routines. With a user-friendly website and excellent customer service, Exhale Wellness is an ideal choice for anyone looking to buy quality CBD gummies online.

BudPop: Innovation in CBD Gummies

BudPop is relatively new to the CBD market but has quickly gained a reputation for its innovative approach to wellness products. Their CBD gummies are crafted using a unique blend of natural ingredients, designed to provide not just the benefits of CBD but also enhanced flavors that set them apart from the competition. BudPop places a strong emphasis on quality, sourcing their hemp from local farms that follow stringent organic practices.

The range of flavors offered by BudPop is another highlight, appealing to both new users and experienced consumers. They understand that taste is a critical factor when it comes to gummies, and they aim to make CBD consumption a delightful experience. Each gummy is loaded with a precise dosage of CBD, making it easy for users to track their intake. Moreover, BudPop’s commitment to transparency ensures that all their products are rigorously tested in independent laboratories to confirm their quality and efficacy.

BudPop has also created a strong community around their brand, engaging with customers and listening to feedback. Their interactive approach fosters loyalty and trust among users. Many partners and influencers advocate for BudPop, further solidifying their standing as a reliable source for CBD gummies. If you’re looking for a brand that combines innovation with quality, BudPop is an excellent option.

Hollyweed CBD: A Natural Approach to Wellness

Hollyweed CBD takes a back-to-basics approach in creating its range of CBD products, including their popular gummies. This brand is known for its commitment to using natural, high-quality ingredients sourced from organic hemp plants in the U.S. Hollyweed focuses on transparency, providing customers with comprehensive information about their production processes, ingredients, and lab results, emphasizing the brand’s integrity.

One notable aspect of Hollyweed CBD’s gummies is their formulation, which combines various natural fruit flavors to create a delightful taste experience without unneeded sugar and artificial sweeteners. This aspect resonates particularly well with health-conscious consumers. Hollyweed’s gummies are also gluten-free and vegan, addressing dietary restrictions while still appealing to a broad audience.

Furthermore, customer satisfaction is of paramount importance to Hollyweed, and they actively seek feedback to enhance their offerings continually. Many users have shared positive experiences regarding the effectiveness of the gummies for managing anxiety, promoting better sleep, and alleviating daily stress. With an intuitive online platform and quick shipping, Hollyweed CBD represents a trustworthy destination for purchasing CBD gummies.

Cheef Botanicals: Blending Tradition with Modern Practices

Cheef Botanicals is a brand well-known for its holistic approach to health and wellness, offering a wide variety of CBD products that include their delectable gummies. The company prides itself on using natural ingredients, focusing on traditional wellness practices combined with contemporary science to create products that are effective and safe. Cheef Botanicals sources its hemp from organic farms based in the United States, ensuring that their CBD is both potent and free from pesticides.

The unique aspect of Cheef Botanicals’ gummies lies in their commitment to consistent and quality dosing. Each gummy contains a uniform amount of CBD, making it easy for customers to manage their daily intake effectively. Additionally, these gummies are enriched with a blend of superfoods designed to enhance overall health, thereby contributing not only to CBD benefits but also to a more balanced lifestyle.

Cheef Botanicals has cultivated an enthusiastic customer base, with numerous testimonials praising the taste, quality, and effectiveness of the CBD gummies. Their dedication to customer service, coupled with easy returns and a satisfaction guarantee, gives consumers confidence in purchasing from their online store. Cheef Botanicals represents a combination of traditional wisdom and modern wellness solutions, making them a commendable option for CBD gummies.

CBDistillery: Pioneering Quality Assurance

As one of the pioneers in the CBD industry, CBDistillery has built a solid reputation for its high-quality products, competitive pricing, and transparency. The company aims to provide a no-nonsense approach to CBD, educating consumers about the benefits of cannabinoids and the differences between THC and CBD. Their CBD gummies stand out due to their efficacy and flavor, making them a popular choice amongst consumers.

CBDistillery takes pride in its rigorous testing protocols, with all products subjected to third-party lab tests to ensure potency and purity. Each buyer can access lab results on the website, enhancing customer confidence in the effectiveness of the products. Offering a wide range of flavors and potency options, CBDistillery caters to various preferences, helping users find the ideal gummy for their needs.

Customer reviews highlight the effectiveness of CBDistillery gummies in relieving symptoms related to anxiety, chronic pain, and sleep disorders. The brand invests heavily in customer satisfaction, offering fantastic customer service and educational resources that empower consumers to make informed decisions. For anyone looking for reliable, high-quality CBD gummies, CBDistillery is a trustworthy choice that emphasizes transparency and user satisfaction.

Common Questions About CBD Gummies

When navigating the world of CBD gummies, questions often arise regarding dosage, legality, and the potential benefits. It is crucial to understand that while CBD is widely regarded as a natural remedy, its effects can vary from person to person. The recommended dosage can depend on individual factors such as body weight, metabolism, and the specific ailment being addressed. It is advisable to start with a low dose and gradually increase it until the desired effects are achieved.

Legality is another primary concern for many consumers. In the United States, CBD derived from hemp with less than 0.3% THC is federally legal, although state laws may vary. Consequently, consumers should be aware of regional regulations. Buying from reputable sellers who provide transparency and lab results is essential to ensure compliance and product safety.

Finally, many individuals wonder about the potential health benefits of CBD gummies. Research indicates that CBD may help to alleviate symptoms of anxiety, stress, inflammation, and chronic pain while promoting overall wellness. Despite promising studies, more extensive research is needed to conclusively establish these benefits. Consulting with healthcare professionals before beginning any CBD regimen aligns well with responsible health practices, ensuring that consumers make informed and safe choices.

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As the debate on the legalization of marijuana continues to intensify, a new trend has emerged – giving marijuana to dogs. Advocates claim that marijuana can provide numerous health benefits for our furry friends, while critics argue that it poses significant risks. In this article, we will examine the potential benefits and risks of using marijuana for dogs, as well as provide guidance for pet owners who may be considering this controversial treatment option.

The Benefits of Marijuana for Dogs

Proponents of giving marijuana to dogs argue that it can provide relief from a variety of health issues, including chronic pain, inflammation, anxiety, seizures, and nausea. Many pet owners have reported seeing significant improvements in their dogs’ quality of life after introducing marijuana into their treatment regimen. In some cases, marijuana has been a last resort for dogs with terminal illnesses, offering them comfort and relief in their final days.

One of the main active compounds in marijuana, cannabidiol (CBD), has been shown to have anti-inflammatory, analgesic, and anti-anxiety properties. This makes it particularly promising for dogs suffering from conditions such as arthritis, cancer, and separation anxiety. CBD is also non-psychoactive, meaning it does not produce the “high” typically associated with marijuana use, making it a safe option for dogs.

In addition to CBD, tetrahydrocannabinol (THC) is another compound found in marijuana that can provide benefits for dogs. THC has been shown to stimulate appetite, reduce nausea, and alleviate pain in dogs. However, it is important to note that THC can be toxic to dogs in high doses, so it is crucial to use it cautiously and under the guidance of a veterinarian.

The Risks of Marijuana for Dogs

While there are potential benefits to using marijuana for dogs, there are also significant risks that pet owners should be aware of. One of the main concerns is the potential for toxicity, especially if dogs ingest THC-containing products in large quantities. Symptoms of marijuana toxicity in dogs can include lethargy, vomiting, disorientation, and even seizures. In severe cases, marijuana toxicity can be life-threatening and require immediate veterinary intervention.

Another risk of using marijuana for dogs is the lack of regulation and standardization in the industry. The quality and potency of marijuana products can vary widely, making it difficult for pet owners to know exactly what they are giving their dogs. This can lead to overdosing or unintended side effects, further complicating an already complex issue.

Furthermore, the long-term effects of marijuana use in dogs are not well understood. While some studies have shown promising results in the short term, there is still limited research on the potential long-term consequences of regular marijuana use for dogs. It is essential for pet owners to weigh the potential benefits against the risks before deciding to use marijuana for their furry friends.

Guidance for Pet Owners

If you are considering using marijuana for your dog, it is important to consult with a veterinarian who is knowledgeable about cannabis-based treatments for pets. A qualified veterinary professional can help you navigate the available options, determine the appropriate dosage for your dog, and monitor for any potential side effects or complications. Additionally, it is essential to use only high-quality, lab-tested marijuana products that are specifically formulated for pets.

It is also crucial to start with a low dose and gradually increase it until you find the optimal level for your dog. This can help minimize the risk of overdosing and allow you to monitor your dog’s response to the treatment closely. Keep an eye out for any unusual behavior, changes in appetite, or adverse reactions that may indicate a negative response to the marijuana.

Lastly, be sure to store marijuana products securely out of reach of your dog to prevent accidental ingestion. Dogs are curious creatures and may be tempted to sample any treats or oils that are left within their reach. By taking proper precautions and working closely with your veterinarian, you can help ensure a safe and effective experience for your dog if you choose to explore the use of marijuana as a treatment option.

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While some components of marijuana, such as CBD, can be safe and beneficial for dogs, THC can be toxic in high doses. It is essential to use marijuana products cautiously and under the guidance of a veterinarian.

What are the potential benefits of using marijuana for dogs?

Marijuana has been reported to provide relief from pain, inflammation, anxiety, seizures, and nausea in dogs. It can also stimulate appetite and improve overall quality of life for dogs with certain health conditions.

What are the risks of giving marijuana to dogs?

The main risks of using marijuana for dogs include toxicity, lack of regulation in the industry, and unknown long-term effects. It is crucial for pet owners to consider these risks carefully and consult with a veterinarian before using marijuana for their dogs.

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