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In an office in Bagsværd near Copenhagen, young biotechnologist Lotte Bjerre Knudsen has been made project manager for a promising, but uncertain project of converting the hormone GLP-1 into a drug that can prove effective in combating the rapidly growing wave of diseases such as type 2 diabetes in the 1990s. If she fails, the project will fold. Follow Episode 2 "If you don't fix this" of this advent calender from the Novo Nordisk Foundation "The Story of GLP-1". 00:00:00 - Introduction: Lotter Knudson's project on GLP-1 00:00:03 - The aim of converting GLP-1 into a drug 00:00:21 - The high stakes of the project 00:00:46 - Initial failed experiments with native GLP-1 00:01:14 - Innovative ideas for stabilizing GLP-1 00:01:50 - Use of fatty acids and albumin for protection 00:02:06 - Issues with purifying fatty acid-bound GLP-1 00:02:22 - A small crisis meeting and the biology-chemistry interplay 00:02:37 - Breakthroughs in understanding GLP-1’s biology 00:03:07 - The built-in safety switch of GLP-1 00:03:31 - Discoveries in Copenhagen on insulin and glucagon secretion 00:04:00 - Challenges in treating people with GLP-1 00:04:08 - Discovery of DPP-4 enzyme’s role 00:04:17 - Development of DPP-4 enzyme inhibitors 00:05:01 - Historical analogies with ACE inhibitors 00:05:47 - Development of DP4 inhibitors 00:06:18 - Long-acting GLP-1 analogs and their limitations 00:06:48 - Chemistry innovations to stabilize GLP-1 00:07:02 - John Eng’s discovery of Exendin-4 from Gila monster venom 00:08:02 - Challenges faced in patenting and developing Exendin-4 00:08:42 - Collaboration with Amylin Pharmaceuticals 00:09:53 - Management challenges and a deadline to fix the GLP-1 project 00:10:06 - Revisiting the initial solutions with new resources 00:10:48 - Issues in clinical trials and correct dosing 00:11:22 - Market competition and the first GLP-1 drug approval 00:12:00 - Investor skepticism and motivation to succeed

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Christina Aguilera’s latest photos have fans doing a double take—she looks almost unrecognizable. After opening up about her past struggles with body image, many are now speculating if Ozempic played a role in her dramatic transformation. Her recent red carpet appearance has reignited rumors, and the internet can’t stop talking. Is it just glow-up... or something more? #christinaaguilera #xtina #ozempic #celebrity #entertainment #celebritynews Subscribe To Beyond The Screen: @beyondthescreen Time Codes: 00:00 – Christina Aguilera’s NEW Photoshoots Leave Fans Speechless 01:24 – Christina Opens Up About Struggling With Weight as a Teen 02:05 – Christina’s STUNNING Appearance on the Recent Red Carpet Sparks Ozempic Rumors Hosted By: Ashleigh: https://www.instagram.com/ashleighbaby333/ Edited By: May: https://www.instagram.com/honghong0702/

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Lizzo is speaks out after fans alleged she used Ozempic to lose weight, soon after she debuted a slimmer figure on social media. The 36-year-old included a selfie video of herself along with the caption, “When you finally get ozempic allegations after 5 months of weight training and calorie deficit.” Full Story: https://www.eonline.com/news/1407641/lizzo-unveils-before-and-after-look-at-weight-loss-transformation #lizzo #weightloss #enews Subscribe: http://bit.ly/enewssub About E! News: The E! News team brings you the latest breaking entertainment, fashion and Pop Culture news. Featuring exclusive segments, celebrity highlights, trend reports and more, the E! News channel is the only destination Pop Culture fans need to stay in the know. Download The E! News App For The Latest Celebrity News and Trending Videos: https://eonline.onelink.me/yMtl/4ead5017 Your favorite shows, movies and more are here. Stream now on Peacock. https://bit.ly/PeacockEEnt Connect with E! News: Visit the E! News WEBSITE: http://eonli.ne/enews Like E! News on FACEBOOK: https://www.facebook.com/enews/ Check out E! News on INSTAGRAM: https://www.instagram.com/enews/ Follow E! News on TWITTER: https://twitter.com/enews Shop E! Insider picks on Amazon: https://www.amazon.com/shop/enews Lizzo RESPONDS to Ozempic Allegations After Debuting Weight Loss Transformation | E! News http://www.youtube.com/user/enews

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📌 Ozempic vs Lantus Insulin for Weight Loss – Real Study Results You Need to Know! Can insulin help you lose weight like Ozempic? 💉⚖️ This short video compares real study results on Ozempic (GLP-1) vs. Lantus insulin when it comes to weight loss. Discover which medication delivers better fat-loss results — and why the difference matters in 2025! #Shorts #YouTubeShorts #ViralShorts #trendingshorts #HealthTips #DiabetesCare #DoctorExplains #Trending #MustWatch #WatchNow #ForYou #Explore #ViralVideo #ShortsFeed #YouTubeViral #ShortClips #TrendingNow #OzempicTrend #OzempicWeightLossTrend #WeightLossTrend ============================================= Disclaimer – Fair Use Our videos do not negatively impact the original works. The content we create is for informational and educational purposes only. We use only the audio component and small portions of video footage when necessary. DISCLAIMER: Copyright Disclaimer under Section 107 of the Copyright Act 1976, allowance is made for “fair use” for purposes such as criticism, comment, news reporting, teaching, scholarship, education, and research. Fair use is a legally permitted use under copyright law that might otherwise be infringing.

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Unlock your inner athlete! Learn how losing body fat improves your jump height. We explore the connection between lean muscle, power, and explosive vertical leap. Discover how to maximize your power-to-weight ratio for peak athletic performance. #jumphigher #jumphigher #athleticperformance #fitness #weightloss #powertraining #verticaljump #strengthtraining #bodycomposition #fitnessmotivation #workout

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