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In this first segment, we look at how effective GLP-1 treatments are. Two standout medications are Semaglutide (known as Ozempic and Wegovy) and Tirzepatide (or Mounjaro). At the highest dose, Semaglutide helps people lose an average of 15% of their total body weight, while Tirzepatide has shown even more impressive results with a loss of 21% of total body weight. Both are promising options for those looking to manage their weight. Next, we'll talk about how to take GLP-1 medications. Most of these drugs, like Ozempic, Wegovy, and Mounjaro, are given as weekly shots. This means fewer doses, making it simpler for patients. But there's also a pill version of Semaglutide called Rybelsus, which is taken daily. This is great for those who prefer pills over injections. When starting GLP-1 medications for weight management, patients usually begin with the lowest dose. Initially, the weight loss progress is checked every month. For patients losing a pound or more each week, they stick with that dose. For patients losing weight more slowly, the dose would typically be increased. Once the right dose is found, it can be continued for the long term and the dose no longer needs to be adjusted monthly. And the good news? There's typically no need for routine lab tests before starting the medication. Now, we'll talk about who qualifies for GLP-1 medications. These drugs, first made for type 2 diabetes, are now used for weight loss. If your BMI is 30 or above, you qualify based on BMI alone. If your BMI is 27 or higher you can also qualify if you have a weight related condition such as high blood pressure, diabetes, prediabetes, or high cholesterol. Lastly, those who have diabetes can qualify for a GLP-1 as a treatment for diabetes. At this point, we'll talk about who might not be a good fit for these medications. They're not recommended for people with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2. Those with stomach issues like gastroparesis or a history of pancreatitis should also be cautious. Always chat with your doctor to see if these drugs are safe for you. Let's talk about possible side effects. GLP-1 medications can sometimes lead to digestive issues like nausea, vomiting, or diarrhea, and you might feel tired or fatigued too. These side effects are usually strongest after your first dose or when the dose goes up. The good news is they typically only last about a day and go away on their own. That's why we often suggest taking the medicine on a Saturday so you can rest at home and not deal with discomfort at work. When using GLP-1 medications, it's important to be aware of potential interactions with other drugs. If you're also taking diabetes medications like insulin or sulfonylureas, there's a risk of low blood sugar, so close monitoring is essential. Additionally, GLP-1s might affect the absorption of certain drugs, like birth control pills, potentially reducing their effectiveness. Let's discuss the costs. GLP-1 medications like Semaglutide (Ozempic, Wegovy, or Rybelsus) and Tirzepatide (Mounjaro) can be expensive, sometimes more than $1,000 per month. The good news is that insurance, especially private insurance, often covers most of the cost. To get insurance coverage, your doctor will need to submit a prior authorization to your health insurance company, usually after sending your prescription to the pharmacy. The insurance approval process typically takes about one week but can sometimes take longer, up to a few weeks. If you're looking for more affordable options, compounding pharmacies offer custom versions that are often a few hundred dollars per month, shipping included. To find the best option for your budget, talk to your doctor and insurance company. As a side note, another potential issue regarding the accessibility of these medications is that they are extremely popular and are sometimes sold out at pharmacies due to high demand. Research shows that sustaining weight loss through diet and exercise alone without the help of medication is tough. Studies show that most dieters gain back most of the weight they lost within two years. But, using GLP-1 medications like Ozempic, Wegovy, or Mounjaro offers a different story. Those who continue to take their GLP-1 medication tend to maintain their weight loss and avoid regaining the pounds. GLP-1 medications provide a helpful tool to break the cycle of yo-yo dieting seen with the usual weight loss methods that use diet and exercise changes alone. This is why it is usually recommended to take GLP-1 medications long term to maintain the benefits. If you stop taking them, your weight is likely to go back up to where it was before starting the medications. So, it's important to see GLP-1 medications as part of a long-term plan, not a quick fix.