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GLP-1 agonists are a family of peptides that have become popular in the early treatment of diabetes type ll. Achieving the right purity for these peptides is however quite challenging. A set of purification methods have been developed using Kromasil stationary phases for removal of impurities in peptide crudes that can be combined in a systematic way to improve purity from crude to 99.5%. This set is called the GLP-1 agonist purification toolbox. Kromasil - from analytical to process-scale chromatography: https://www.kromasil.com/

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Oral weight loss medications include: 1. Phentermine- Increases energy and reduces appetite. Potential side effects include increased heart rate and blood pressure. Not recommended for individuals over 65 or those with a history of heart disease. Slight chance of worsening glaucoma 2. Topiramate- Suppresses appetite and improves sleep. Common side effects include dopiness and sleepiness. Should not be used on anyone with glaucoma or history of kidney stones 3. Naltrexone/Wellbutrin- Primarily reduces cravings (rather than appetite) and can improve mood. Possible side effects include nausea, vomiting, and vivid dreams. Not suitable for individuals using narcotics or those with a history of seizures. Slight chance of worsening glaucoma 4. Metformin-Helps reduce cravings for sugary and carbohydrate-rich foods, supports blood sugar regulation, and can be beneficial for individuals on antipsychotic medications. Common side effects include abdominal discomfort, diarrhea and gas. 5. Orlistat (available on amazon, approximately $60/month)- Blocks fat absorption from food. Side effects may include oily stools, floating stools, and possible staining of underwear if gas is passed. 6. Plenity (available at myplenity.com)- Expands in the stomach to promote fullness and reduce food intake. A rare but serious side effect includes the risk of obstruction in the stomach or intestines. 7. Vyvanse- Approved for the treatment of binge eating disorder. Side effects include increased heart rate and blood pressure. Not recommended for individuals over 65 or those with a history of heart disease. 8. Injectables: GLP-1 and GLP1/GIP Receptor Agonists: *coverage restricted. Reduces appetite and cravings, slows gut emptying, supports blood sugar regulation. Reduces chance of heart attack and stroke even if you do not lose weight. It takes several months to work up to an effective dose.

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