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Hormone Happy Hour - January 15 Meeting Purpose Impromptu Zoom meeting to discuss hormone therapy, client questions, and GLP-1 agonists. Key Takeaways Metformin can be beneficial for weight loss, PCOS, and gut health, but may deplete CoQ10 and B vitamins Bioidentical hormone replacement therapy (BHRT) can be safe and beneficial when properly administered and monitoredGLP-1 agonists may help with weight loss but should be used alongside lifestyle changes and proper nutrition education Topics Hormone Therapy and Fertility Copper peptide (GHK-CU) recommended for hair and skin health, safe for both men and women Metformin discussed as potential aid for PCOS, weight loss, and gut health Fertility optimization involves addressing inflammation, insulin resistance, and thyroid function BHRT benefits include bone, brain, and heart protection, with potential to reduce hip fractures, cardiovascular disease, and Alzheimer's risk GLP-1 Agonists for Weight Loss Potentially beneficial for severe food addiction or eating disordersMay cause digestive issues in those with pre-existing conditions Should be used short-term alongside proper nutrition educationEffectiveness depends on individual health status and ability to make lifestyle changes Hormone Feedback Mechanisms LH and FSH regulate hormone levels through feedback loops PCOS often presents with high LH and lower FSH, causing excess androgensMetformin can help lower LH pulse and regulate hormones in PCOS patients Supplements and Medications Berberine discussed as antimicrobial but often poorly tolerated For male fertility: high-quality vitamin D, methylated B vitamins, and L-carnitine recommended Compounded bioidentical hormones preferred over synthetic forms
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GLP-1 Agonists for Obesity in Non-Diabetic Patients: Game Changer or Overhyped? | A Critical Clinical Review GLP-1 receptor agonists are reshaping the treatment landscape for obesity—even in patients without diabetes. But are they truly a game-changing intervention or an overhyped pharmacologic trend with major limitations? In this comprehensive analysis, we critically examine the clinical efficacy, cardiovascular outcomes, safety profile, real-world limitations, and economic impact of GLP-1 agonists—drawing from major trials like SELECT, SURMOUNT, and recent meta-analyses. We compare leading agents including semaglutide, tirzepatide, and emerging triple agonists such as retatrutide. You'll learn: How GLP-1 RAs affect appetite, energy homeostasis, and cardiovascular risk Differences in weight loss efficacy among GLP-1 agents in non-diabetic populations Long-term adherence challenges and the risks of weight regain The emerging safety landscape, including GI side effects and perioperative risks Cost-effectiveness concerns, access barriers, and global policy considerations Who is this for? This lecture is designed for physicians, pharmacists, endocrinologists, obesity specialists, and healthcare leaders seeking a balanced, evidence-based perspective on the role of GLP-1s in modern obesity treatment. Whether you're prescribing these agents or designing treatment protocols, this session offers vital insights into optimizing use and anticipating future directions. 🎯 Is it a breakthrough or just hype? We present the evidence—so you can decide. 📌 Subscribe to GlobalRPh for more in-depth clinical content on pharmacotherapy, metabolic health, and practice-changing evidence.
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How Testosterone Affects Fat Loss: Real Science of Low-T | Thomas DeLauer: I'm sick of the lack of legitimacy behind testosterone, so let's clear some of this up. I work with a lot of men that are battling Low-T by helping them with their lifestyle at http://www.ThomasDeLauer.com As men age, their testosterone levels decline. This is exacerbated by an increase in SHBG (sex-hormone binding globulin), which binds to testosterone and thus reduces the amount of free testosterone in the body. Low testosterone levels have been linked to obesity and many other health problems, including fatigue, memory problems and reduced muscle and bone mass. So what is the impact of testosterone on body fat? Testosterone and energy - low levels of testosterone are linked with low energy levels. Regaining regular testosterone levels can increase energy and lead to weight loss. Studies have found that testosterone supplementation reduces total body fat percentages. Obesity is often correlated with low testosterone levels in men. Just as testosterone therapy is associated with decreased obesity, losing weight is associated with increased testosterone levels. An article published in 2014 in the journal of Current Opinion in Endocrinology, Diabetes and Obesity looked at the existing data regarding testosterone therapy in overweight and obese men with testosterone deficiency (hypogonadism). -Many weight loss supplements have dangerous side effects or are ineffective -Looked at weight loss, BMI, waist circumference and body composition -Evaluated long-term testosterone therapy -About 40% of obese nondiabetic men and 50% of obese diabetic men over 45 have low levels of free testosterone -Many studies have found that testosterone therapy in obese men is correlated with increased lean body mass, weight loss, decreased BMI and reduced waist circumference. -Weight loss is significant and sustained with long-term testosterone therapy Testosterone plays a part in protein, fat and carbohydrate metabolism. -Testosterone is involved with mitochondrial function and thus energy production and utilization -This interference with energy production is likely why those with low testosterone levels experience a lack of energy -Testosterone therapy has been found to increase lipid oxidation and normalize glucose use in the body. It was found to increase energy and motivation. Weight gain is associated with an 88% increase in body fat and a 12% increase in lean body mass (LBM) and weight loss with a 72% decrease in body fat and a 28% decrease in LBM. -With testosterone therapy LBM has been shown to increase. -Increased LBM means increased energy expenditure at rest -Testosterone therapy is also associated with improved cardiometabolic function Testosterone deficiency is linked with a decrease in energy metabolism from fat and an increase in energy metabolism from glucose. -Testosterone therapy has been shown to increase lipid metabolism Safety? Safety is the main concern with testosterone replacement therapy. Possible risks discussed in literature include: -Increased risk of prostate and breast cancer -Liver toxicity and tumors -Sleep apnea exacerbation -Testicular infertility and atrophy It is necessary to talk with your doctor before starting testosterone therapy. Summary: If you are a male struggling to lose weight, testosterone therapy is a promising treatment to help with not only weight loss but body composition, energy levels and overall health. References: 1. Dose-dependent effects of testosterone on regional adipose tissue distribution… http://press.endocrine.org/doi/10.1210/jc.2003-031492?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed 2. Testosterone and weight loss: the evidence https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154787/ 3. Effects of testosterone treatment on body fat and lean mass in obese men on a hypocaloric diet… https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054608/ 4. The benefits and risks of testosterone replacement therapy: a review https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701485/
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Welcome to another episode of I Feel Fat Today with your host Kelly Taylor. This week Kelly sits down with fellow New Jersey native & stand up comedian, Christiana Jackson. Christiana tells us about teenage herbal diet pill usage (they are herbal so they are healthy, DUH!), astrological relationships, traveling around the world meeting some exciting gentlemen callers, and so much more. If you’re asking yourself, “Which country has the hottest guys?” Listen now to find out! Don't forget to rate, review, and subscribe to the podcast, and spread the word to your friends. Follow I Feel Fat Today on Instagram: @ifeelfattoday Send us an email: [email protected] Follow Kelly Taylor on Instagram: @hellothisiskelly Follow Christiana Jackson: @incomparablemsc SUBSCRIBE TO OUR YOUTUBE CHANNEL! https://www.youtube.com/@IFeelFatToday
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