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REFERENCE for Curious Interested Listeners & Physicians (Below) 59,25Mar2025 Here’s what we’re covering in this Video Podcast: • How they work: These meds help regulate blood sugar and curb appetite, driving their popularity for weight loss. • Side effects: Nausea, diarrhea, and fatigue are common, but rare cases involve more serious issues like pancreatitis and muscle loss. • Shortages & controversies: Demand has led to pharmacy shortages, underground markets, and government crackdowns. Stay tuned for Part 2, where we’ll explore the biggest myths, long-term effects, and what research really says about these medications! • The weight loss question: They work while you’re on them, but what happens when you stop? Many regain the weight lost. • Mounjaro vs. Ozempic: Which is better? Some studies say Mounjaro leads to greater weight loss, but it’s not that simple. 1. Animal Studies Alhadeff AL, Rupprecht LE, Hayes MR. (2012). Glucagon-like peptide-1 receptor signaling in the ventral tegmental area attenuates food intake. Journal of Neuroscience, 32(25), 8112-8120. Showed GLP-1 drugs reduce food-seeking behavior by acting on brain reward areas. 2. Brain Reward Pathways Dickson SL, Shirazi RH, Hansson C, et al. (2012). The role of GLP‑1 receptor activation in the central regulation of energy balance and reward. Physiology & Behavior, 106(2), 231–238. Explains how GLP-1 receptors in the brain influence eating for pleasure, not just hunger. 3. Incretin Hormones Review Nauck MA & Meier JJ. (2018). Incretin hormones: Their role in health and disease. Diabetes, Obesity and Metabolism. Details the dual role of GLP-1 in gut and brain signaling. 4. The SURPASS-2 Trial Jastreboff, A. M., et al. (2022). Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes (SURPASS-2): A Randomized, Open-Label, Parallel-Group, Phase 3 Trial. This study and provided weight loss data for both tirzepatide (Mounjaro) and semaglutide (Ozempic). 5. The SURPASS Clinical Trials (Review and Meta-Analysis) Frías, J. P., et al. (2022). Insights from the SURPASS Clinical Trials: A Systematic Review and Meta-Analysis of Tirzepatide in Type 2 Diabetes. Diabetes, Obesity and Metabolism. Discusses how the additional GIP receptor activity might contribute to enhanced weight loss. 6. Eli Lilly (Mounjaro) https://www.lilly.com/news/media/media-kits/mounjaro https://mounjaro.lilly.com 7. Novo Nordisk (Ozempic) https://www.novonordisk.com.au/our-products-for-healthcare-professionals.html https://rss.medsinfo.com.au/no/pi.cfm?product=nopozemp In this video, we’re diving into the truth behind Mounjaro (tirzepatide) vs. Ozempic (semaglutide)—two medications originally developed for type 2 diabetes but now gaining attention for weight loss. The hype is huge, but what’s really going on? Novo Nordisk Eli Lilly

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Octavia Pickett-Blakely, MD, MHS, covers the basics of drug therapy for weight loss, before or after bariatric surgery. Dr. Pickett-Blakely discusses what to expect and the different types of anti-obesity medication, including appetite reducers and metabolic drugs. The cost of drug therapy and insurance coverage of treatment is also discussed. Learn more about Dr. Pickett-Blakely: https://www.pennmedicine.org/providers/profile/octavia-pickett-blakely #PennMedicine #BariatricSurgery

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