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Jennifer L. Costello, PharmD, BCPS, BC-ADM, ambulatory care clinical pharmacist at Saint Barnabas Medical Center, gives a few tips for pharmacists with patients on weight-loss medications, such as liraglutide and naltrexone/bupropion. For patients who receive a once-daily subcutaneous injection of liraglutide, pharmacists can help educate patients with regard to dosage—which will gradually increase. It will take up to 5 weeks to be on the full dose of 3 milligrams once a day, Dr. Costello notes. Pharmacists should remind patients taking naltrexone/bupropion that they should never separate the agents and take them individually. Pharmacists should also make sure that these patients are not on any other agents due to serotonin syndrome risks and other potential adverse drug interactions.

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GLP-1 agonists have been a breakthrough for the treatment of obesity, a global problem with serious health risks. While the benefits of these therapies are seen as outweighing the risks, there have been some concerns about the loss of muscle mass, particularly in older people using these drugs. iBio is developing next-generation obesity therapies that may be able to be used in combination with GLP-1 agonists or by themselves. Its lead experimental therapy is a myostatin inhibitor, part of a class of therapies that have been of interest to treat muscle wasting. We spoke to Martin Brenner, CEO and chief scientific officer of iBIO, about obesity, the limits of GLP-1 agonists, and the potential for myostatin inhibitors alone or in combination with GLP-1 agonists.

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