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In this conversation, experts discuss the implications of GLP-1 receptor agonists like Ozempic in the context of weight loss and the supplement industry. They explore the mechanisms of GLP-1, the importance of diet and exercise, and the challenges faced by individuals using these medications. The panelists emphasize the need for a comprehensive approach to obesity, including dietary changes and physical activity, while also addressing the role of natural products and emerging research in metabolic health. They conclude with thoughts on the future of weight management and the importance of consumer education in navigating the supplement landscape. Please see the links below for more information on our guests’ companies. • Dr. Jacqueline Jacques, ND – Wellness Industry Expert, obesity specialist, vocal critic of “natural Ozempic” claims o https://www.bariatricadvantage.com/ o https://www.mvpnutra.net/ o https://shop.myeq.com/ • Jim Ayres – CEO of Kelker Pharma, product development and contract manufacturing leader o https://kelkerpharma.com/ • Dr. Luc Maes, ND – Founder of KAIBAE, expert in gut–metabolic axis, polyphenols, and microbiome science o https://maescenter.com/ o https://www.baobabingredients.com/ o https://gokaibae.com/ • Michael Bengivenga – SVP, New Business Development Vitaworks, experienced in brand and commercial development in the supplement space o https://vitaworksusa.com/ Keywords GLP-1, Ozempic, weight loss, supplements, obesity, metabolic health, diet, exercise, natural products, health industry Takeaways • GLP-1 receptor agonists have been around for over 20 years, starting with Bayetta in 2005. • These drugs work by reducing appetite and improving insulin sensitivity. • Natural products may not replicate the effectiveness of GLP-1 drugs but can support metabolic health. • Weight loss requires a comprehensive approach, including diet, exercise, and possibly supplements. • The obesity epidemic is multifactorial, requiring attention to food systems and education. • GLP-1 medications can lose effectiveness over time due to receptor desensitization. • Post-biotics are emerging as a promising area for supporting metabolic health. • Consumer education is crucial in navigating the supplement industry and avoiding misinformation. • The future of weight management may involve multi-target formulations that complement GLP-1 drugs. • A holistic approach to health includes physical activity, diet, and mental well-being. Chapters 00:00 Introduction to Ozempic and the Supplement Industry 11:57 Understanding GLP-1 Receptor Agonists 17:56 The Role of Natural Products in Weight Loss 23:42 Compounded vs. Branded GLP-1 Drugs 26:49 The Role of Compounders in Drug Manufacturing 27:55 Emerging Medications and Their Impact 28:49 Addressing the Obesity Epidemic 29:58 Food Systems and Health Education 31:45 Weight Loss and Muscle Mass Concerns 33:43 The Importance of Comprehensive Weight Loss Strategies 35:41 Formulating Effective Nutraceuticals 39:58 Understanding GLP-1 Efficacy and Challenges 48:49 Cultural Perspectives on Eating Habits 49:50 Intermittent Fasting and Metabolic Health 50:35 Ingredients for Metabolic Support 52:26 The Role of the Microbiome in Obesity 55:56 Innovative Ingredients in Weight Management 01:00:53 Final Thoughts on GLP-1 and Weight Management

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