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This video will explain how metformin is useful for weight loss, especially in PCOS cases. But this drug needs proper prescription guidance for diabetes, bodybuilding, and for weight loss. Because self-medication can harm you. •Take this medication by mouth as directed by a doctor, usually 1-3 times a day with meals. •Drink plenty of fluids while taking this medication Side effects of metformin •Nausea, vomiting, stomach upset, diarrhea, •weakness, or a metallic taste in the mouth may occur. •Stomach symptoms that occur after the first days of your treatment may be signs of lactic acidosis. •Metformin does not usually cause low blood sugar (hypoglycemia). if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. Keep a list of all the products you use Do not start, stop, or change the dosage of any medicines without your doctor approval.Beta-blocker medications (such as metoprolol, propranolol, glaucoma eye drops such as timolol) may prevent the the symptoms of hypoglycemia. #Metforminhydrochloride500mgtablet #metforminweightloss #metformintablet500mg #metforminsideeffects #metforminhindi #metforminpcos Disclaimer: This video is for educational and general informational purposes only and it helps in the general understanding of various health issues. It should not be used to self-diagnose and it is not a substitute for a medical exam, cure, treatment, diagnosis, and prescription or recommendation. It does not create a doctor-patient relationship between us and you. You should not make any change in your treatment, health regimen or diet before first consulting a physician and obtaining a medical exam, diagnosis, and recommendation. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Shaun Tips is not liable or responsible for any advice, course of treatment, diagnosis or any other information, services or product you obtain through this video or site. This video is not for sale. #shauntips
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GLP-1 receptor agonists are not new. They've actually been around for quite some time. Dr Priya Jaisinghani explains.
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Patient in this case is @East-Bound (check out his YouTube Channel!) @chubbyemu video of this case: https://www.youtube.com/watch?v=ChPeG19qKUo Christopher's recount of his case: https://www.youtube.com/watch?v=7BpymtR2vpA Audio podcast for Heme Review: https://anchor.fm/chubbyemu Tweet me: https://www.twitter.com/hemereview IG me: https://www.instagram.com/hemereview FB me: https://www.facebook.com/hemereview Timestamps: 0:00 - Introduction 0:30 - Can you tell me about yourself? 1:21 - How did you get into lifting weights? 3:14 - Bernard talking about his high school experience 4:12 - What was your relationship like with the gym? 5:48 - How did things change in Christopher's life at the end of high school? 8:17 - Other people's perception of weight 9:24 - Christopher describing long time girlfriend cheating on him 10:32 - People judging others based on weight 14:45 - How did you get back in to fitness during college? 17:54 - Weight loss plateau 20:54 - Weight loss supplements 24:46 - Transition from supplements to harder weight loss chemicals 31:04 - What is clenbuterol like? 33:40 - How did you come across DNP? 35:41 - What is being on DNP like? 40:00 - How long did you take DNP for? 44:58 - What do you remember from day of accident? 50:19 - Tales from the emergency room, September 3 2015 51:10 - Waking up in the ICU 55:25 - How did the accident change your relationship with the gym? 57:54 - What would you tell someone thinking of taking DNP today? 2,4-Dinitrophenol (DNP) is a chemical that is not approved for weight loss. It is a classic case of efficacy, but without safety in the setting of weight loss. This setting of weight loss can be prone to chemical misuse, further exacerbating understanding in human systems. Christopher is one of 2 - 3 cases documented in literature to have survived an accident with DNP for weight loss. As of 2021, one organization has permission from the US FDA to investigate DNP in some neurodegenerative disorders. These are rare diseases with limited standards of care, therefore extenuating circumstances to find anything that could potentially improve patient outcomes. References: Role of dantrolene in dinitrophenol (DNP) : A continuing question? Am J Emerg Med. 2019 Jun;37(6):1216.e1-1216.e2. https://pubmed.ncbi.nlm.nih.gov/30948257/ 2,4-dinitrophenol (DNP): a weight loss agent with significant acute toxicity . J Med Toxicol. 2011 Sep;7(3):205-12. https://pubmed.ncbi.nlm.nih.gov/21739343/ Ambient temperature and mortality from unintentional . JAMA. 1998 Jun 10;279(22):1795-800. https://pubmed.ncbi.nlm.nih.gov/9628710/ Beware the yellow slimming pill: fatal 2,4-dinitrophenol. BMJ Case Rep. 2016 Apr 4;2016. https://pubmed.ncbi.nlm.nih.gov/27045052/ Dantrolene is not the answer to 2,4-dinitrophenol poisoning: more heated debate. BMJ Case Rep. 2018 Dec 19;11(1):e225323. https://pubmed.ncbi.nlm.nih.gov/30573533/ The effect of 2,4-dinitrophenol on adipose-tissue metabolism. Biochem J. 1969 Feb;111(4):431-44. https://pubmed.ncbi.nlm.nih.gov/4388239/ The mechanism of uncoupling of oxidative phosphorylation by 2,4-dinitrophenol. J Biol Chem. 1967 Oct 25;242(20):4577-83. https://pubmed.ncbi.nlm.nih.gov/4964808/ MECHANISMS OF DINITROPHENOL TOXICITY. Simon E.W. Biological Reviews. Vol 28. (4). Nov 1953. Identification and Importance of Brown Adipose Tissue in Adult Humans. https://www.nejm.org/doi/full/10.1056/NEJMoa0810780 Mitochondrial uncoupling as a target for drug development for the treatment of obesity. Obes Rev. 2001 Nov;2(4):255-65. https://pubmed.ncbi.nlm.nih.gov/12119996/ LC-MS-MS analysis of 2,4-dinitrophenol and its phase I and II metabolites. J Ana Toxicol. Jan-Feb 2007;31(1):55-61. https://pubmed.ncbi.nlm.nih.gov/17389084/ Uncouplers of oxidative phosphorylation. Environ Health Perspect. 1990 Jul;87:213-8. https://pubmed.ncbi.nlm.nih.gov/2176586/ Texas Woman Charged with Selling Misbranded https://www.fda.gov/inspections-compliance-enforcement-and-criminal-investigations/press-releases/texas-woman-charged-selling-misbranded-drug
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GLP-1 is a satiety hormone that is naturally produced by the body that is now also used as a drug in weight loss drugs like semaglutide. In a presentation at the American Society of Nutrition conference, Dr. Arne Astrup shared some studies showing that meals that are higher in protein and lower in carbohydrate naturally increases levels of GLP-1 released from the intestine which in turn leads to higher satiety, or the feeling of fullness after a meal. GLP-1 stimulates satiety by signaling in the brain to suppress appetite and also slows gastric emptying, so you feel full for longer. These are some of the underlying mechanisms of protein-induced satiety, and a good reminder to aim to incorporate some protein into meals and snacks. That’s what science tastes like. Subscribe to Nourishable at https://www.youtube.com/@nourishable Become a patron and help Nourishable create more evidence-based nutrition science content! https://www.patreon.com/nourishable Follow Nourishable to stay up to date on all things nutrition. https://x.com/nourishable fb.me/nourishable.tv https://www.instagram.com/nourishable/ Hosting, Research and Writing by Lara Hyde, PhD www.youtube.com/@nourishable The information in this video is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images and information, contained on or available through this video is for general information purposes only.
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