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GLP-1 is secreted by intestinal cells in response to glucose ingestion and acts on the vagus nerve and hypothalamus to induce satiety. Subscribe to Nourishable at https://www.youtube.com/c/Nourishable This video is part 6 of the Neurobiology of Food Intake module within a lecture series on the nutrition science of macronutrients. Neurobiology of Food Intake Lecture playlist: https://youtube.com/playlist?list=PLK6oS2Cd-6PE_gAHJP2eQaP01IrvL7OQJ Macronutrients Lecture playlist: https://youtube.com/playlist?list=PLK6oS2Cd-6PGI0ALaBRBb10s51Z0NEmvw Follow Nourishable on twitter, facebook and instagram to stay up to date on all things nutrition. https://twitter.com/nourishable fb.me/nourishable.tv https://www.instagram.com/nourishable/ Lecture Development, Hosting & Post-Production by Lara Hyde, PhD http://www.nourishable.tv Video Production by Robbie Hyde https://www.youtube.com/user/chedderchowder Opening Motion Graphics by Jay Purugganan https://www.c9studio.com/WP/ The information in this video is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images and information, contained on or available through this video is for general information purposes only. References Klockars, A. et al. Hypothalamic Integration of the Endocrine Signaling Related to Food Intake. Curr. Topics Behav. Neurosci. (2019) 43:239-270 Images Figures created with BioRender Glucagon-like peptide 1, or GLP-1, is a hormone secrets by the L cells in the intestine in response to glucose ingestion in proportion to consumed calories. GLP-1 stimulates insulin secretion from the pancreas to prepare the body for high blood glucose levels - this makes it an incretin because it increases insulin. Further, GLP-1 inhibits glucagon. GLP-1 binds to chemoreceptors on the vagus nerve to activate the vagus to send afferent signals to stimulate the nucleus tractus solitarius in the hindbrain to stimulate satiety. GLP slows gastric emptying which keeps the GI tract stretched and distended for longer - this activates the stretch-sensitive mechanoreceptors on the vagus to additionally stimulate the NTS. GLP-1 crosses the blood-brain-barrier of the hypothalamus to activate the POMC neurons in the arcuate nucleus. POMC neuron stimulation causes release of the neurotransmitter alpha MSH which stimulates the paraventricular hypothalamus to induce satiety. GLP-1 also inhibits the orexigenic AgRP neurons. GLP-1 is an anorexigenic, satiety-inducing hormone.

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