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Even as we prioritize natural interventions in functional medicine, GLP-1 agonist drugs such as Wegovy and Ozempic offer sometimes life-changing support for those who have long struggled with resistant overweight/obesity and high blood sugar. However, there are side effects, including the risk of substantial muscle loss and sagging, aged skin ("Ozempic face" as it's indelicately known). It's a concern that hits home for me, considering the pivotal role we know that muscle plays in overall health and longevity. In this New Frontiers podcast episode I welcome back Dr. Anurag Singh to unravel the complexities of these issues. We explore the interplay between metabolic health and muscle preservation, touching on everything from the mechanisms of GLP-1 agonists and their long-term effects on aging and sarcopenia, to the promising potential of dietary and lifestyle interventions to counteract negative effects. We consider the potential for one of my all-time fave postbiotic epinutrients - Urolithin A - to assist by supporting mitochondrial health and preserving/enhancing muscle quality. This timely conversation is one you won't want to miss. Tune in and please leave us a review wherever you listen to New Frontiers. – DrKF Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for all the relevant links and resources. *Guest information* Anurag Singh, MD, PhD Chief Medical Officer at Timeline *Thank you to our sponsor* Timeline: https://tinyurl.com/4npjcvjf Mitopure: https://tinyurl.com/ypfjws2e Research from Timeline: https://tinyurl.com/53p6yjc9 [email protected] *Timeline Discount for New Frontiers Listeners* Timeline is offering Dr. Fitzgerald’s readers a 10% discount on Timeline products. Head on over to https://tinyurl.com/ypfjws2e and use the code KARA10 at the checkout. *Show Notes* Study: Once-Weekly Semaglutide in Adults with Overweight or Obesity: https://tinyurl.com/y3c2ypkw Pre-clinical trial (Recruiting): Effects of Urolithin A Supplementation on Glucose Metabolism in Healthy Adults 55= Years Old: A Randomized Triple-Masked Controlled Clinical Trial - https://https://tinyurl.com/bdzfccr8 Study: Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults - https://tinyurl.com/2p9pjpxc Study: Antidiabetic Effect of Urolithin A in Cultured L6 Myotubes and Type 2 Diabetic Model KK-Ay/Ta Mice with Glucose Intolerance - https://tinyurl.com/2jkhmu9w Study: Urolithin A, a Gut Metabolite, Improves Insulin Sensitivity Through Augmentation of Mitochondrial Function and Biogenesis - https://tinyurl.com/mvrjxxsm Study: Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults A Randomized Clinical Trial - https://tinyurl.com/fscfdd85 Study: The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans - https://tinyurl.com/mr2hd4ms Study: Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population - https://tinyurl.com/e6npdvyp Preprint article: Topical application of Urolithin A slows intrinsic skin aging and protects from UVB-mediated photodamage: Findings from Randomized Clinical Trials - https://tinyurl.com/2m2nzd56 Preclinical trial: Effects of Mitopure (Urolithin A) on Skeletal Muscle Function, Iron Metabolism and Endurance Performance (ENDURO) - https://tinyurl.com/nhkw2pvc Study: The gut microbiota metabolism of pomegranate or walnut ellagitannins yields two urolithin-metabotypes that correlate with cardiometabolic risk biomarkers: Comparison between normoweight, overweight-obesity and metabolic syndrome - PubMed (nih.gov) - https://tinyurl.com/mrkk33e5 Study: Urolithin A exerts antiobesity effects through enhancing adipose tissue thermogenesis in mice | PLOS Biology - https://tinyurl.com/3s38vtau Study: Urolithin A production drives the effects of pomegranate on the gut microbial metabolism of bile acids and cholesterol in mild dyslipidaemic overweight and obese individuals - PubMed (nih.gov) - https://tinyurl.com/wdzk3tx7 *DrKF Resources* FxMed Podcast: Beyond Mitochondrial Health: Can Urolithin A Slow Down Aging? - https://tinyurl.com/svzahswu DrKF Blog: Beyond Beauty: Targeting Skin Longevity with Urolithin A - https://tinyurl.com/5n6zfu9s DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb Bio Age Lab Test: https://tinyurl.com/b7bjmfj9 Bio Age Self Assessment Quiz: https://tinyurl.com/4z8f7ucc Younger You Group Program: https://tinyurl.com/4hvusavw Younger You book: https://tinyurl.com/mr4d9tym Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw

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Site: https://www.checkout-ds24.com/redir/580934/Demetrius1980/ Welcome to the Beauty and Body Care Tips channel! Today, we’re going to talk about the Mitolyn dietary supplement, designed to improve mitochondrial health, promote energy production, and aid in weight management. Mitolyn’s advanced formula combines scientifically proven ingredients that work synergistically to deliver comprehensive benefits for the body and mind. The main benefits of Mitolyn include increased production of ATP, the main source of cellular energy, resulting in higher energy levels and increased productivity throughout the day. To incorporate it into your routine, it is recommended to take the capsules with a glass of water, preferably with meals, to maximize nutrient absorption. It is important to consult a healthcare professional before starting any supplement.In the first few days of use, you may notice a gradual increase in energy levels and a reduction in fatigue. Mitolyn is more than a supplement; it is an investment in your health and vitality, helping you address challenges related to energy and metabolism. With continued use, you can feel more energized and motivated. Mitolyn's formula includes L-Carnitine, which transports fatty acids to the mitochondria, promoting fat burning, and Alpha-Lipoic Acid, an antioxidant that aids in glucose metabolism. It also contains B vitamins and minerals such as magnesium, essential for cellular function and energy metabolism.Other ingredients, such as resveratrol and green tea extract, help speed up metabolism and fat burning. Curcumin and black pepper extract improve absorption and offer anti-inflammatory properties. Mitolyn works holistically, promoting balance in the body and protecting cells from damage. Whether you are a professional looking for more energy, an athlete or someone who wants to improve overall health, Mitolyn is the right choice. The supplement is available on the official website, and the link is in the description. See you in the next video! If you liked it, share and subscribe to the channel. #mitolyn #mitolynreview #mitolynreviews #mitolynhonestreview watch this video: 00:00- Welcome to the Beauty and Body Care Tips channe 00:18- Mitolyn 04:44- subscribe to the channel. Welcome to the channel: https://youtu.be/9hNo52PNI3s

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Welcome to Downsized Live with Christopher & Laraine! We’re LIVE and ready to answer YOUR questions about GLP-1s—whether you’re taking Zepbound, Mounjaro, tirzepatide, Wegovy, Ozempic, Rybelsus, semaglutide, or even liraglutide (Saxenda, Victoza)... this is your place to be heard. We’ve lost more than 150 pounds combined—and we’re still on this adventure with you. Tonight, we’re talking about what’s working, what’s confusing, and what we’ve learned so far. We’ll answer your questions in real time and share updates from our own GLP-1 experiences. 💬 Ask your questions live in the chat 🎯 Tell us where you are on your GLP-1 adventure ❤️ Stick around—you’re not alone on this path 🔔 New to our channel? Subscribe and hit the bell so you don’t miss a live stream. 📍 Just a reminder: We’re not doctors. We’re real people sharing our real experiences with GLP-1s. Always talk to your healthcare provider before starting or changing any treatment. BOOK THE DOWNSIZED AT SEA CRUISE: https://thedownsized.org/downsized-at... DOWNSIZED WEBSITE: https://thedownsized.org/ DOWNSIZED GLP-1 COMPANION PRODUCT STORE: https://thedownsized.org/downsized-store JOIN CLUB DOWNSIZED: / @thedownsized FOR SPONSORSHIPS, BRAND DEALS & COLLABS: https://thedownsized.org/contact/