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Discussing GLP-1 Agonists and Weight Loss Journeys with James Newburrie In this episode of The Downsized, hosts Christopher and Laraine Durham share their experiences with GLP-1 agonists Zepbound, Mounjaro, Wegovy, Ozempic, semaglutide, tirzepatide, and its substantial impact on their weight loss journey. They welcome James Newburrie, a computer nerd from Melbourne, Australia, who discusses his lifetime struggle with weight, the toxic diet culture of the 1980s, and his transformative experience with GLP-1 medications. James highlights the significant lifestyle and dietary changes he undertook and the profound mental shifts facilitated by these medications. This episode dives deep into personal hardships, the flawed diet industry, and the scientific approach to addressing metabolic disorders. 🌟 DOWNSIZED GLP-1 COMPANION PRODUCT STORE: https://thedownsized.org/downsized-st... DOWNSIZED WEBSITE: https://thedownsized.org/ Start your weight loss journey today! We use Mochi Health: https://joinmochi.com/. Use Laraine’s code for $40 off: QIYGO8. 00:00 Introduction to The Downsized 00:40 Meet James Newburrie 01:17 James' Early Struggles with Weight 02:25 The Impact of 1980s Diet Culture 03:38 The Blame Game: Food Industry and Beyond 06:59 James' Turning Point in 2019 08:07 Pandemic Challenges and Weight Gain 13:19 Discovering GLP-1 Medications 17:29 Life-Changing Effects of Trizepatide 21:52 Reevaluating Life and Free Will 22:59 Shared Struggles and Fitness Goals 24:05 Diet Fatigue and Relationship with Food 24:54 Concerns About Medication Availability 25:30 Cost and Logistics of Medication 26:32 Side Effects and Adjustments 28:41 Diet and Nutrition Details 33:00 Toxic Diet Culture Discussion 40:17 Reflections and Future Plans 41:43 Closing Remarks and Gratitude

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GLP1 drugs are highly effective at weight loss, but it comes at a cost. The approach requires expertise and oversight from an expert. There are several strategies that can help prevent or manage muscle mass loss associated with GLP-1 agonist treatment: ## Resistance Training Incorporating resistance or strength training exercises is one of the most effective ways to preserve and build muscle mass during weight loss[1][2]. This counteracts the catabolic effects of caloric deficit by stimulating muscle protein synthesis. ## Adequate Protein Intake Ensuring sufficient dietary protein intake, ideally 1.6-2.2 g/kg of ideal body weight per day, can help minimize muscle loss[2]. Protein provides amino acids needed for muscle maintenance and repair. ## Combining with Myostatin Inhibitors Myostatin is a key negative regulator of muscle growth. Blocking myostatin with investigational drugs like apitegromab (SRK-439) from Scholar Rock may enhance muscle growth and prevent muscle loss when combined with GLP-1 agonists[1]. Early clinical trials are underway to test this approach. ## Using Activin Receptor Inhibitors Activin receptor inhibitors like those being developed by companies like Regeneron can block activin signaling and potentially increase muscle mass when used alongside GLP-1 medications[3]. ## mTOR Activators The mTOR pathway regulates muscle protein synthesis. Drugs that activate mTOR, such as the PPAR agonist enobosarm being tested by Veru, may preserve muscle when combined with GLP-1 treatment[5]. ## Adequate Vitamin D and Calcium Ensuring sufficient vitamin D and calcium intake is important for preserving bone mineral density, which can be impacted by the weight loss and muscle loss induced by GLP-1 agonists[2]. The key is utilizing a multi-modal approach combining GLP-1 agonists with resistance exercise, optimal nutrition, and emerging muscle-preserving medications to maximize fat loss while minimizing the loss of metabolically active lean muscle mass[1][2][3]. Citations: [1] https://pharmanewsintel.com/features/addressing-muscle-loss-associated-with-glp-1-medication-use [2] https://www.medscape.com/viewarticle/994030 [3] https://www.tctmd.com/news/dont-worry-about-muscle-loss-glp-1-inhibitors-viewpoint-asserts [4] https://www.uclahealth.org/news/article/rapid-weight-loss-can-lead-loss-muscle-mass [5] https://www.drugdiscoverytrends.com/glp-1-impact-lean-mass/

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