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What is Ozempic Face? This short reveals the hidden side effect everyone’s whispering about — sunken cheeks, hollow eyes, and why it happens. 👇 Got questions? Drop them below or email us: [email protected] #OzempicFace #Ozempic #WeightLossSideEffects #Shorts Disclaimer: This video is for educational and informational purposes only. It is not intended to diagnose, treat, cure, or prevent any disease. Always consult with a qualified healthcare professional before making any medical decisions or starting any treatment, including the use of Ozempic or similar medications.

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Obesity, a driver of inflammation, is prevalent in patients with HFpEF. Ileana Pina asks Ambarish Pandey about GLP-1 inhibitors and SGLT2 inhibitors in HFpEF. Are these drugs anti-inflammatory? https://www.medscape.com/viewarticle/993980?src=soc_yt -TRANSCRIPT- Ileana L. Piña, MD, MPH: Hello, everyone. I'm Ileana Piña, professor of medicine at Jefferson University Hospital in Philadelphia. I'm the chief of quality. This is my blog. We have been hearing a lot of conversation about obesity. It's coming out of our endocrine division and our weight management division. And the patients are asking for things like bariatric surgery and maybe a holistic program of weight loss. A lot of the primary care doctors are starting to recommend glucagon-like peptide-1 (GLP-1) receptor agonists for those patients. But we deal with patients with heart failure with preserved ejection fraction (HFpEF), and a lot of our phenotypes are patients with obesity who happen to have hypertension and/or diabetes, and they are difficult to manage. Inflammation, Obesity, and HFpEF Piña: For today's conversation, there is nobody better than Dr Ambarish Pandey, who has a HFpEF program at the University of Texas Southwestern. Ambarish, welcome. Give me your thoughts overall about the link between obesity, inflammation, and HFpEF. Ambarish Pandey, MD: Thank you, Dr Piña. I'm excited to be on your blog and I'm glad that we are discussing such an important topic. The burden of heart failure, particularly HFpEF, has been increasing and is not just affecting older individuals. We see more younger folks with obesity in our HFpEF clinic coming in with symptoms of shortness of breath and fluid buildup. Our understanding of HFpEF has evolved quite a bit over the past two or three decades. Initially, it was thought to be a disease of largely impaired myocardial relaxation. And then Walter Paulus was one of the pioneers who proposed the concept of inflammation leading to HFpEF, and obesity being one of the important drivers of the inflammation that leads to the development of HFpEF. Now our understanding of HFpEF has evolved to it being a multisystem disorder that leads to dysfunction in different organ systems. One of the cardinal features that drives this dysfunction is upregulation of inflammatory pathways, increased inflammatory burden — and a lot of that is driven by obesity. Obesity is one of the most important modifiable risk factors for HFpEF. Piña: It is so common. In my clinic the other day, probably 3 out of 4 patients were obese. Pandey: Up to 75% of patients that we see in our program are over the 30 BMI cut-off, and a lot of the literature that has come from US HFpEF cohorts shows a very high average BMI in these patients. Piña: When we talk about inflammation, what are the chemical pathways of inflammation? For example, a long time ago, we tried to block TNF-alpha and it didn't quite work out. So, what pathways are we talking about? Pandey: I think a lot more work needs to be done to really understand the key drivers of inflammation and what pathways are being upregulated. As we know, inflammation is most commonly identified by elevation in levels of C-reactive protein (CRP), which serves as a marker of increased inflammation, but the upstream upregulation in IL-1– and IL-6–mediated pathways has been implicated in inflammation that drives development of diseases like HFpEF. There is an ongoing trial of ziltivekimab, which is an IL-1 inhibitor in patients with HFpEF. That's the HERMES trial led by Paul Ridker, one of the pioneers of inflammatory therapies in heart disease. We are starting to understand more about the key molecular pathways that are driving it. And now we're starting to target them, with the hope that we can actually halt the progression of HFpEF and improve the symptom burden as well as the risk for adverse outcomes in these patients. Are GLP-1 Inhibitors Anti-inflammatory? Piña: Do you think that the GLP-1s, or even now the SGLT2 inhibitors, are anti-inflammatory since we really don't know all the pathways? Pandey: I do think that GLP-1s, by virtue of causing weight loss and reduction in visceral adiposity and the bad fat depots that exist in our body, have a significant anti-inflammatory effect. And if you look at the data from the STEP trials that were done, looking at weight loss effects of semaglutide, a commonly used GLP-1 inhibitor, there was a good 30%-40% reduction in CRP levels, and that suggests that there is a significant anti-inflammatory effect. Now, whether it's a direct effect on anti-inflammatory pathways or is related to weight loss is a matter of debate. Piña: Are you using GLP-1 inhibitors in your HFpEF clinic? And what trials can we look forward to seeing concerning the use of these agents? https://www.medscape.com/viewarticle/993980?src=soc_yt

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🚨 10 + 1 FOODS You MUST STOP EATING to LOSE FAT ⛔ (Or You’ll NEVER Achieve It) 🚨 Are you tired of dieting and exercising but still not seeing results? This video is for YOU! Today, I’m revealing the 10 + 1 foods you MUST AVOID if you want to lose fat effectively. These foods are the main culprits holding you back from reaching your goals, and I’ll tell you exactly why! 📌 In this video, you’ll learn: ✅ Why ultra-processed foods and packaged snacks are sabotaging your progress. ✅ How sugary drinks and processed juices are making you gain fat fast. ✅ The negative impact of white bread and refined bakery products on your metabolism. ✅ Why fried foods and deep-fried snacks are enemies of your health and weight loss. ✅ The risks of processed meats like bacon, sausages, and deli meats. ✅ How alcohol and sugary desserts are slowing down your fat-burning process. ✅ And much more, including a BONUS that will surprise you! 💡 Practical tips: I’ll share healthy alternatives to replace these foods so you can still enjoy delicious meals while losing fat. 👉 If you’re ready to transform your body and health, this video is a MUST-WATCH. Don’t miss it! 🔔 Subscribe to the channel and hit the bell icon for more tips on fat loss, nutrition, and healthy living. Give this video a thumbs up if you found it helpful, and share it with someone who needs it! #LoseFat #FatLossFoods #HealthyNutrition #WeightLossTips #BurnFat #HealthyLifestyle Electrodoodle de Kevin MacLeod tiene una licencia Atribución 4.0 de Creative Commons. httpscreativecommons.orglicensesby4.0

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Lose Belly Fat with these 5 Beginner Level Belly Fat Exercises for Beginners, you learn how to lose belly fat in 1 week at home in Hindi with No Gym and No Equipment Exercises. These are Best Exercises which are both gender friendly and beginner friendly too, yes these can be easily done by men, women and for any one who is overweight and obese and find it difficult to sit on the floor or stand. Not only will these easy and simple exercises help you lose weight but also help you in reducing your belly fat and giving you a thin waist. I am Natasha Mohan Weight Loss Expert and these are the following 5 Belly Fat Exercises for Beginners which you can do right there sitting on a chair , In the First Exercise you will learn is the Easy Seated Leg Lifts for Lower Belly Fat which is done While Sitting on the Chair, extend and gradually rise your leg to 90 Degree angle , while the other foot remains stationed on the floor. This amazing exercises Strengthens the abdominal muscles, improves digestion, and helps to burn fat too. In My Second Exercises that you will learn is Easy Alternating Toe Touches for a Slim Waist, This is an An easy Beginner Friendly exercise for reducing belly fat and love handles, a classic core strengthening exercise to tighten your abdominal muscles.The Third Exercises that you will learn is Sitting Side bends for Love Handles, It's very usual for Beginners to have lots of issue with their Side belly fat or called Love Handles or also called side abdomen fat, this exercise will surely work wonders on them when no other exercises seems to work to cure this problem. The Forth Exercises that you will learn is Hanging Leg Raises Leg Lift to lose Belly Fat , This is a Must do exercise , helping and strengthening while toning your lower belly, Leg raises are great for your abs and the obliques. It helps in building stronger abs, increase stability and strength, melt belly fat and tone your body. The Best and the final Exercise is Seated Arms to Legs Oblique Exercises which is one of the Best Exercises for Beginners as It helps in a strong core while burning off the belly fat and giving a slim waistline. Link to My Instagram Page :- https://www.instagram.com/weightloss.diet.hindi/ Link to My Facebook Page :- https://www.facebook.com/health.weightloss.tv.hindi/ TO see more Natasha Mohan Exercises by playlist :- https://www.youtube.com/playlist?list=PLHnFIPNFTBnqWkh9fkTajy-t7WCzpB_58 LINK TO MY ENGLISH WEIGHT LOSS CHANNEL ( Weight Loss with Natasha Mohan ) :- https://www.youtube.com/channel/UCJMxEj6vqzN6GpiIzxds2iA Friends, on this channel I am sharing with you my views & personal weight loss experiences which have helped me a lot through my weight loss journey.These remedies & tips have worked on me but that does not mean they will automatically work for you as circumstances vary from person to person. Always consult your doctor before beginning any diet, nutrition, lifestyle ,exercises or weight loss program. All information you see here is designed for educational and entertainment purposes only and should not be treated as substitute, nor does it replace, professional medical advice, diagnosis or treatment.The use of information provided here is at your sole risk. Thanks for understanding. ALL RIGHTS RESERVED. IF YOU COPY MY VIDOES OR THUMBNAILS WITHOUT MY PERMISSION , I WILL REPORT YOU FOR COPY RIGHT INFRINGEMENT. #bellyfatexercises #natashamohanexercises #bellyfatworkout #losebellyfat #homeworkout #losebellyfatfast #losebellyfatin1week #slimwaistexercises #easybellyfatexercises

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