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Join Drs Nihar Desai and Matthew Cavender as they discuss the history, studies, and implementation of GLP-1 receptor agonists for people with cardiorenal metabolic syndrome. Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/999842. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Glucagon-Like Peptide-1 Receptor Agonists https://www.ncbi.nlm.nih.gov/books/NBK551568/#:~:text=Glucagon%2Dlike%20peptide%2D1%20(,options%20for%20these%20endocrine%20diseases. Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death From Cardiovascular Causes https://pubmed.ncbi.nlm.nih.gov/17517853/ Guidance for Industry on Diabetes Mellitus-Evaluating Cardiovascular Risk in New Antidiabetic Therapies to Treat Type 2 Diabetes; Availability https://www.federalregister.gov/documents/2008/12/19/E8-30086/guidance-for-industry-on-diabetes-mellitus-evaluating-cardiovascular-risk-in-new-antidiabetic Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes https://pubmed.ncbi.nlm.nih.gov/27295427/ Effects of Oral Semaglutide on Cardiovascular Outcomes in Individuals With Type 2 Diabetes and Established Atherosclerotic Cardiovascular Disease and/or Chronic Kidney Disease: Design and Baseline Characteristics of SOUL, a Randomized Trial https://pubmed.ncbi.nlm.nih.gov/36945734/ Semaglutide and Cardiovascular Outcomes in Obesity Without Diabetes https://pubmed.ncbi.nlm.nih.gov/37952131/ Heart Failure With Preserved Ejection Fraction (HFpEF) https://www.ncbi.nlm.nih.gov/books/NBK599960/ Effects of Liraglutide on Clinical Stability Among Patients With Advanced Heart Failure and Reduced Ejection Fraction: A Randomized Clinical Trial https://pubmed.ncbi.nlm.nih.gov/27483064/ Semaglutide Versus Placebo in People With Obesity-Related Heart Failure With Preserved Ejection Fraction: A Pooled Analysis of the STEP-HFpEF and STEP-HFpEF DM Randomised Trials https://pubmed.ncbi.nlm.nih.gov/38599221/ Interpreting the Kansas City Cardiomyopathy Questionnaire in Clinical Trials and Clinical Care: JACC State-of-the-Art Review https://pubmed.ncbi.nlm.nih.gov/33183512/ Comparison of Tirzepatide and Dulaglutide on Major Adverse Cardiovascular Events in Participants With Type 2 Diabetes and Atherosclerotic Cardiovascular Disease: SURPASS-CVOT Design and Baseline Characteristics https://pubmed.ncbi.nlm.nih.gov/37758044/ Coordinated Care to Optimize Cardiovascular Preventive Therapies in Type 2 Diabetes: A Randomized Clinical Trial https://pubmed.ncbi.nlm.nih.gov/36877177/
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Keto ? Here’s What It Does to Your Hormones #ketoalternative #ketodiet #glp1 #insulinresistance #ketolifestyle You've heard it everywhere: "Cut all carbs to lose fat." "Keto is the fastest way to burn fat." But here’s what science now tells us: ✅ 1. Keto Isn't for EveryoneStudies show that long-term keto can raise LDL cholesterol, reduce gut microbiome diversity, and may even accelerate biological aging. 📖 Zinöcker et al. (2021)Journal: Frontiers in NutritionTitle: The Ketogenic Diet and Its Impact on Gut Microbiota Diversity and FunctionDOI: 10.3389/fnut.2021.702253🔗 https://doi.org/10.3389/fnut.2021.702253 📖 Seidelmann et al. (2018)Journal: The Lancet Public HealthTitle: Dietary carbohydrate intake and mortality: a prospective cohort study and meta-analysisDOI: 10.1016/S2468-2667(18)30135-X🔗 https://doi.org/10.1016/S2468-2667(18)30135-X ✅ 2. You Don’t Have to Fear CarbsIt’s not about cutting all carbs. It’s about eating them with strategy. Combine carbs with protein and fiber. Eat protein first, carbs last. Start your day with a high-protein breakfast. These practices lower post-meal glucose, trigger GLP-1, and improve satiety — without extreme restriction. 📖 Tan et al. (2022)Journal: NutrientsDOI: 10.3390/nu14142966🔗 https://www.mdpi.com/2072-6643/14/14/2966 📖 Shukla et al. (2015)Journal: Diabetes CareDOI: 10.2337/dc15-0429🔗 https://diabetesjournals.org/care/article/38/7/e98/37247 📖 Jakubowicz et al. (2013)Journal: ObesityDOI: 10.1002/oby.20460🔗 https://onlinelibrary.wiley.com/doi/10.1002/oby.20460 ✅ 3. Balanced Carbs + Fiber = Long-Term HealthNot all carbs are created equal. Avoid refined sugars and ultra-processed white bread — yes. But embrace fiber-rich, complex carbs like: Brown rice Oats Sweet potatoes Leafy greens Avocados Fruits and legumes They support gut health, cardiovascular function, and help trigger GLP-1 naturally. 📌 SummaryKeto can offer short-term fat loss, but long-term, it’s not always sustainable or safe. Instead of fearing carbs, eat them smart: Pair with fiber and protein Time them wisely Focus on whole foods This is how you burn fat — with science, not shortcuts. 🏷 Hashtags#GlucoseShocking #KetoFacts #SmartCarbs #GLP1 #FiberPower #FatLossTips #GutHealth #GLP1Foods #ScienceBacked #GlucoExpert #KetoSideEffects
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