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Computer crashed and I went off program. Pretty much summarizes what happened in the last two weeks. Getting back on track this week for an awesome weight loss next week.

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Are you considering combining GLP-1 drugs with rapamycin for weight loss and longevity? In this video, Leslie explores the critical risks of taking these drugs together, despite their popularity among celebrities for shedding pounds and slowing aging. While GLP-1 drugs like Ozempic help suppress appetite, rapamycin, a powerful anti-aging drug, works differently by inhibiting mTOR, a pathway essential for muscle growth and cellular repair. Leslie explains why using both can lead to muscle wasting, nutrient deficiencies, and other serious health risks—and offers safer alternatives for sustainable weight management and longevity. Discover why focusing on a high-protein, spermidine-rich diet, regular strength training, and targeted supplements may be a better strategy for your health journey. Whether you’re already using GLP-1 drugs or simply exploring options for a healthier, longer life, this video is packed with insights to guide you. Don’t miss the breakdown of safe, effective ways to protect muscle mass and stay fit for the long haul! #GLP1 #Rapamycin #Ozempic #WeightLossTips #Longevity #HealthyAging #MuscleHealth #Spermidine #NewPrimeOfLife #LeslieKenny #WeightLossJourney Leslie’s New Prime channel is sponsored by Oxford Healthspan. To learn more, visit https://oxfordhealthspan.com ------------- 🌐 Connect with Leslie for more healthy aging rituals & tips: • YouTube: https://www.youtube.com/@LesliesNewPrime • Instagram: https://www.instagram.com/lesliesnewprime • LinkedIn: https://www.linkedin.com/in/leslie-kenny-oxford • Facebook: https://www.facebook.com/lesliesnewprime/ • Linkt.ree: https://linktr.ee/lesliekenny • Website: https://www.lesliesnewprime.com/ • Newsletter Sign Up: https://mailchi.mp/5658721e02f2/leslielingli • Take the Gray Hair Detective Quiz: https://form.typeform.com/to/aJ851jXU • Free e-book: Hello Health, Goodbye Gray: https://www.lesliesnewprime.com/ ------------- Disclaimer: I am not a medical professional and all of the content in my videos consists of my own research into scientific matters as well as my own experience experimenting with what the science suggests. It is very much what I believe the science is suggesting but of course everyone has a number of factors that affect their health, which is why I always like to say that n=1 i.e. what works for me might not work for you.

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Presented on August 24, 2022 by Dr. Candelario and Dr. Walker: Brief review of pharmacotherapy of GLP-1 RA and SGLT2-I reminds providers that GLP-1 RA work by activating insulin synthesis and release, delaying gastric emptying, and increasing satiety. SGLT-2 inhibitors work by reducing renal tubular glucose reabsorption, increasing urinary glucose excretion, ultimately reducing serum glucose with additional weight loss and antihypertensive benefits independent of beta cell function. Review of two separate meta-analyses conclude that SGLT2-I therapy and GLP-1 RA therapy result in reduction in all-cause mortality, CV mortality, myocardial infarction, and adverse renal outcomes. Call to action for physicians and providers to routinely evaluate need for use of SGLT2-I in every patient with cardiometabolic or renal disease, not just diabetic patients, and to work closely with pharmacy teams to assist patients with medication cost barriers.