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(USMLE topics) Methamphetamine: mechanism of action, short-term and long-term effects, addiction and overdose. Purchase a license to download a non-watermarked copy of this video on AlilaMedicalMedia(dot)com ©Alila Medical Media. All rights reserved. Voice by: Ashley Fleming All images/videos by Alila Medical Media are for information purposes ONLY and are NOT intended to replace professional medical advice, diagnosis or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition. Methamphetamine, also called meth or crystal meth, among other names, is a psychostimulant drug mainly known for its recreational use. Methamphetamine is chemically similar to amphetamine, a drug used to treat attention-deficit hyperactivity disorder, obesity and narcolepsy; but being more potent and highly addictive, methamphetamine is rarely prescribed for medical treatments. Most commonly, the drug is produced illegally, from pseudoephedrine, an ingredient in cold medicines. It can exist as white powder, pills, or bluish-white crystals, and can be consumed by swallowing, smoking, snorting, or injecting. Methamphetamine acts to increase the amount of a neurotransmitter called dopamine in the brain. Dopamine is at the basis of the brain reward pathway, which is designed to “reward” the body for important behaviors that are essential for survival, such as feeding when hungry. Engaging in enjoyable activities causes dopamine release from dopamine-producing neurons into a space between neurons, where it binds to and stimulates its receptors on the neighboring neuron. This stimulation is believed to produce pleasurable feelings or rewarding effect. Normally, dopamine molecules are promptly cleared from the synaptic space to ensure that the postsynaptic neurons are not over-stimulated. This is possible thanks to the action of dopamine-transporter, which channels dopamine back to the transmitting neuron. Methamphetamine binds to dopamine-transporter and blocks dopamine re-uptake. In addition, it can enter the transmitting neuron and trigger more dopamine release. The result is that dopamine builds-up in the synapse to a much greater amount than normal. This produces a continuous over-stimulation of receiving neurons and is responsible for the prolonged and intense euphoria experienced by drug users. At a low dose, methamphetamine stimulates the brain and can elevate mood and alertness; and by accelerating heart rate and breathing rate, it increases energy in fatigued individuals. It also reduces appetite and promotes weight loss. These seemingly “positive” effects keep users coming back for more, eventually leading to addiction and potential overdose. Long-term drug users may experience extreme weight loss, severe dental damage, and constant hyperactivity which results in anxiety, sleeping disorders and violent behaviors. Overdose takes the drug’s effects to the extreme and can cause psychosis, heart attacks, seizures, strokes, organ failures, and even death. Currently, there is no approved pharmacological treatment for methamphetamine addiction; the most effective treatments are cognitive behavioral therapies.

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Tabata is a four-minute HIIT workout with 20 seconds at maximum or challenging intensity and 10 seconds of rest (8 rounds); a short recovery (around 1-minute); and repeat. The treadmill, spin cycle, Concept 2 Rower, outdoor stair running, and jump rope are my preferred Tabata workout routines. A 5-minute warm-up and a 5-minute cool-down are highly recommended. If possible, try to do 3 to 4 rounds. Limit your recovery time between rounds to around 1-minute so that your muscles stay warm. A Tabata workout at maximum or challenging intensity is difficult to do daily. I can only do it 3 times a week. On the non-Tabata days, I do LESS intense interval training using the same 20/10 interval regime. Instead of counting reps, I do as many reps as possible in 20 seconds when weight or body-weight lifting, TRX Suspension Trainer, etc. If you’re working yourself into physical shape or recovering from an injury, you can do even LESS intense interval training by just fast walking / jogging for 20 seconds and slow walking / jogging for 10 seconds. Remember, “maximum or challenging intensity” is what’s maximum or challenging to you so don’t compare your efforts to others. The use of the song and images in this video is based upon Creative Commons licensing and/or the Fair Use Doctrine. NO COMMERCIAL USE IS INTENDED OR ALLOWED.

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Apple Cider Vinegar (ACV) has been a popular ingredient in weight loss products for years, with claims of helping to shed excess pounds and improve overall health. One such product that has been gaining attention in the market is the Simpli Health ACV Keto supplement. This product claims to not only aid in weight loss but also support ketosis, a metabolic state where the body burns fat for fuel instead of carbs. In this review, we’ll take a closer look at the weight loss claims associated with Simpli Health ACV Keto and whether or not it lives up to the hype.

Understanding the Ingredients of Simpli Health ACV Keto

Simpli Health ACV Keto contains a blend of natural ingredients, with the primary ones being apple cider vinegar, BHB (Beta-Hydroxybutyrate) salts, MCT oil, and green tea extract. Apple cider vinegar is known for its potential to aid in weight loss by increasing feelings of fullness and reducing appetite. BHB salts help the body enter ketosis faster and sustain the state, leading to increased fat burning. MCT oil is a type of fat that is quickly absorbed by the body and converted into ketones, providing a quick source of energy. Green tea extract is rich in antioxidants and catechins, which may help boost metabolism and promote weight loss.

Apple cider vinegar has been studied for its potential to aid in weight loss, with some research suggesting that it may help reduce body weight and fat mass. However, more studies are needed to confirm these findings and determine the exact mechanism behind ACV’s weight loss benefits. BHB salts are a popular ingredient in keto supplements, as they help increase blood ketone levels and induce ketosis without the need for strict dietary restrictions. MCT oil is commonly used in keto diets to promote fat burning and provide a quick source of energy. Green tea extract has been shown to have antioxidant properties and may help boost metabolism, leading to increased calorie burn.

Potential Benefits of Simpli Health ACV Keto

One of the potential benefits of Simpli Health ACV Keto is its ability to aid in weight loss by promoting ketosis and fat burning. By supplying the body with exogenous ketones through BHB salts, this supplement may help individuals reach ketosis faster and experience increased energy levels. Additionally, the inclusion of apple cider vinegar may help reduce cravings and prevent overeating, leading to a reduction in calorie intake. The MCT oil in the formula can provide a quick source of energy and support fat burning during exercise or periods of fasting.

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Aside from weight loss, Simpli Health ACV Keto may also offer other health benefits, such as improved cognitive function and increased endurance. Ketones produced during ketosis have been shown to cross the blood-brain barrier and provide an alternative fuel source for the brain, which may improve cognitive performance and mental clarity. Additionally, MCT oil has been linked to increased endurance and physical performance, making it a popular supplement among athletes and fitness enthusiasts. The antioxidants found in green tea extract may also help protect against oxidative stress and reduce inflammation in the body.

Potential Drawbacks of Simpli Health ACV Keto

While Simpli Health ACV Keto offers promising benefits for weight loss and overall health, there are potential drawbacks to consider before using this supplement. One concern is the lack of long-term studies on the effects of apple cider vinegar and BHB salts on weight loss and metabolism. While some studies have shown positive results, more research is needed to confirm the safety and efficacy of these ingredients for prolonged use. Additionally, some individuals may experience digestive issues or stomach discomfort when taking apple cider vinegar or MCT oil, especially in high doses.

Another potential drawback of Simpli Health ACV Keto is the cost, as this supplement may be more expensive than other weight loss products on the market. Individuals on a tight budget may find it difficult to afford regular use of this supplement, especially if they require multiple bottles for an extended period. Additionally, the taste and smell of apple cider vinegar may be off-putting to some users, making it challenging to incorporate this supplement into their daily routine. It’s essential to consider these factors before purchasing Simpli Health ACV Keto and to consult with a healthcare professional if you have any concerns about its use.

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This video tackles a hot topic: Keto and Carnivore vs. Ozempic and GLP-1 drugs for weight loss. Both strategies are being hailed as game-changers, and people are seeing real results with each. But how exactly do they work? What are the pros and cons of each approach? And most importantly—which one should you choose? Let’s break it all down. The information contained herein is not intended to be used as medical advice or recommendations. Always seek the guidance of a qualified health professional before making any significant changes to your diet and/or lifestyle. Shout out to- @anthonychaffeemd @joerogan @KenDBerryMD @DrEricWestman-AdaptYourLife @DrShawnBakerPodcast @JordanBPeterson @drberg @DoctorBoz @LauraSpath @drekberg Additional Resources: https://fatfueledlife.com https://www.amazon.com/dp/B0BSTPCSJR As an Amazon associate, I earn from qualified purchases at no extra cost to you. KETONE & GLUCOSE MONITORING KIT - https://amzn.to/4cFncxv 5.5 QT AIR FRYER - https://amzn.to/44ozS9P 12.5" CERAMIC COATED INDUCTION FRYING PAN - https://amzn.to/4cGL1oM 5" x 7" GLASS BAKING DISH WITH LID - https://amzn.to/3ExoxJY CARNIVORE SWEETENER - https://amzn.to/4lIoNG5 PROTEIN POWDER - https://amzn.to/3EfXRNX PORK RIND CRUMBS - https://amzn.to/4j7rYpM EGG WHITE POWDER - https://amzn.to/42FPHrr ELECTROLYTE POWDER - https://amzn.to/42bam6A BEEF JERKY SNACK STICKS - https://amzn.to/42tuzn7 WILD CAUGHT TUNA - https://amzn.to/42af5Wa WILD ALASKAN SALMON - https://amzn.to/42FQskh

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