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We were honored to host Professor Robert Lustig, MD, at Emery Pharma once again. Dr. Lustig, a renowned Pediatric Endocrinologist from UCSF, delivered an insightful presentation on the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and its critical links to metabolic dysfunction. Below are the key highlights from his talk: Non-Alcoholic Fatty Liver Disease (NAFLD) Overview NAFLD impacts 45% of Americans and 25% of the global population, often going undetected until complications arise. Once primarily associated with alcohol use, NAFLD is now prevalent in children, largely due to dietary factors like sugar consumption. Key Points from Dr. Lustig's Talk Core Arguments Fat and Metabolic Disease: Obesity is a risk factor but not the direct cause of metabolic diseases like type 2 diabetes and NAFLD. Internal fat distribution (e.g., visceral and liver fat) rather than subcutaneous fat plays a critical role, even in individuals with normal BMI. Fructose as a Toxin: Fructose, found in sugar and processed foods, overwhelms liver mitochondria, driving fat production (de novo lipogenesis). The liver damage caused by fructose is similar to that caused by alcohol, though without affecting the brain. Inflammation and Oxidative Stress: Fructose accelerates oxidative stress and inflammation, contributing to liver fat accumulation, insulin resistance, and type 2 diabetes. Three-Hit Hypothesis: NAFLD arises from three factors: Mitochondrial dysfunction causing fat buildup. Reactive oxygen species (ROS) leading to inflammation. Malnutrition impairing the liver's ability to export fat. Interventions: Addressing dietary quality, particularly by reducing sugar intake, is more effective than focusing solely on weight loss. While exercise and balanced nutrition help, drugs targeting NAFLD are still experimental. Key Data Points Children and NAFLD: 25% of children with type 2 diabetes have a normal BMI, underscoring the impact of diet over obesity alone. Fructose Restriction Study: Replacing fructose with glucose in obese children significantly reduced liver fat and metabolic syndrome markers without weight loss. Comparison to Alcohol: Fructose causes liver damage through similar pathways as alcohol, though it does not affect the brain. Call to Action Dr. Lustig urged for a shift toward reducing sugar consumption as a public health priority, emphasizing that fixing the food supply and curbing processed food consumption is critical to tackling metabolic diseases. Q&A Highlights Dr. Lustig discussed the limitations of GLP-1 agonists, noting their high cost, limited access, and failure to address the root causes of metabolic dysfunction. He reinforced that dietary quality, particularly reducing fructose and processed foods, plays a more significant role in combating these conditions than fat content. Closing Remarks Dr. Lustig emphasized the urgent need for systemic changes in food policies to prevent diseases associated with poor nutrition. He advocated for education and significant reductions in sugar intake as primary strategies to improve public health. To watch the full video of Dr. Lustig’s presentation, click here: https://youtu.be/oIWRmOIR_CM. To access the curated playlist of all Professor Lustig’s talks at Emery Pharma, click here: https://www.youtube.com/playlist?list=PLlTSLi3qD78edU0aWyV8x9yLMIS-FC2fv.

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I'll teach you how to become the media's go-to expert in your field. Enroll in The Professional's Media Academy now: https://www.professionalsmediaacademy.com/ Listen to my podcast, The Checkup with Doctor Mike, here: Spotify: https://go.doctormikemedia.com/spotify/CheckUpSpotify Apple Podcasts: https://go.doctormikemedia.com/applepodcast/ApplePodcasts Help us continue the fight against medical misinformation and change the world through charity by becoming a Doctor Mike Resident on Patreon where every month I donate 100% of the proceeds to the charity, organization, or cause of your choice! Residents get access to bonus content, an exclusive discord community, and many other perks for just $10 a month. Become a Resident today: https://www.patreon.com/doctormike Let’s connect: IG: https://go.doctormikemedia.com/instagram/DMinstagram Twitter: https://go.doctormikemedia.com/twitter/DMTwitter FB: https://go.doctormikemedia.com/facebook/DMFacebook TikTok: https://go.doctormikemedia.com/tiktok/DMTikTok Reddit: https://go.doctormikemedia.com/reddit/DMReddit Contact Email: [email protected] Executive Producer: Doctor Mike Production Director and Editor: Dan Owens Managing Editor and Producer: Sam Bowers Editor and Designer: Caroline Weigum Editor: Juan Carlos Zuniga * Select photos/videos provided by Getty Images * ** The information in this video is not intended nor implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained in this video is for general information purposes only and does not replace a consultation with your own doctor/health professional **

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