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Revolutionizing Weight Loss: New GLP-1 Implant, Court Battles, and Emerging Oral Medications In today's episode of the Downsized News, hosted by Laraine and Christopher Durham, several advancements and controversies in the GLP-1 weight loss treatment landscape were discussed. Key highlights include a groundbreaking new GLP-1 implant designed to eliminate the need for weekly injections, potentially simplifying the weight loss journey for many. Novo Nordisk's latest trial results for their new drug, CMA, show a 15.7% weight loss in participants but face investor skepticism due to production challenges and stiff competition from Eli Lilly's Zepbound. The legal woes of Kourtney Kardashian's supplement brand, Lemme, are also explored, with class action lawsuits alleging misleading claims about their GLP-1 daily supplement. Additionally, Eli Lilly's announcement of a new weight loss pill, Orforglipron, promises easier access and affordability for patients. Viking Therapeutics' strategic partnership with Corden Pharma and OPKO Health’s collaboration with EnteraBio also signal increased competition and choices in the GLP-1 market. Finally, Roche's multi-billion-dollar deal with Zealand Pharma reveals their plan to develop a new weight loss drug that could bring more effective treatments with fewer side effects. The episode underscores the rapid pace of innovation and the competitive nature of the weight loss treatment market, highlighting the potential for new options and better outcomes for patients. BOOK THE DOWNSIZED AT SEA CRUISE: https://thedownsized.org/downsized-at-sea-2025/ DOWNSIZED WEBSITE: https://thedownsized.org/ JOIN CLUB DOWNSIZED: https://www.youtube.com/@thedownsized/join DOWNSIZED GLP-1 COMPANION PRODUCT STORE: https://thedownsized.org/downsized-store 00:00 Introduction and Headlines 01:11 Novo Nordisk's New Drug Trial Results 03:54 Kourtney Kardashian's Supplement Controversy 07:06 Eli Lilly's New Weight Loss P ill 08:28 Innovative GLP-1 Implant by VII Medical 10:59 Viking Therapeutics' New GLP-1 Drug 13:26 OPKO Health and Inter Bio's Oral GLP-1 16:31 Roche and Zealand Pharma's New Weight Loss Drug 17:59 Conclusion and Sign-Off

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Weekly Weigh-In: Christopher Hits His Goal! 🎉 98 lbs Down! + Laraine’s 52.4lb Loss! It’s a HUGE week on The Downsized! 🎉 Christopher has officially hit his weight loss goal for the first time and is now 98 lbs down! 🙌 Meanwhile, Laraine continues her amazing progress with 52.4 lbs lost on her GLP-1 adventure! 🚀 We’re breaking down: ✅ Christopher’s journey to 98 lbs lost and what it feels like to finally hit his goal ✅ Laraine’s continued success at 52.4 lbs down ✅ What’s next for both of us as we continue life with Zepbound, Mounjaro, and compounded tirzepatide ➡️ If you're new to our channel, we’ve lost over 150 lbs together using GLP-1s, and we share the real, raw truth of the adventure every week. 💬 Drop your wins (or struggles) in the comments—we’re all in this together! 🚢 JOIN US ON THE DOWNSIZED AT SEA CRUISE! 🚢 We’d love for you to be part of this incredible adventure! Imagine sailing the Caribbean, meeting other GLP-1 adventurers, and sharing this experience together. It’s going to be an unforgettable trip, and we’d love to see you there! More details coming soon—stay tuned! 🔔 Like, subscribe, and turn on notifications so you don’t miss a weigh-in! We use Mochi Health: https://joinmochi.com/. Use Laraine’s code for $40 off: QIYGO8. BOOK THE DOWNSIZED AT SEA CRUISE: https://thedownsized.org/downsized-at-sea-2025/ DOWNSIZED WEBSITE: https://thedownsized.org/ JOIN CLUB DOWNSIZED: https://www.youtube.com/@thedownsized/join DOWNSIZED GLP-1 COMPANION PRODUCT STORE: https://thedownsized.org/downsized-store

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