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This is an excerpt of the keynote 'Current Status and Potential Future of Obesity Therapies' by Associate Vice President James Trevaskis (Eli Lilly) at the conference Metabolism Day 2025. He provides an insightful overview of the current obesity therapeutics landscape and future innovations beyond GLP-1 receptor agonists, discusses the evolution of obesity treatments, highlights the success of GLP-1s like semaglutide and tirzepatide, while exploring emerging therapies including: Retatrutide - Eli Lilly's tri-agonist (GIP/GLP-1/glucagon) showing up to 24% weight loss Small molecule GLP-1 agonists - Oral alternatives like orforglipron Amylin-based therapies - The next major non-incretin class for obesity treatment Combination approaches - Including activin receptor inhibitors to preserve lean muscle mass during weight loss Trevaskis addresses key challenges in obesity drug development, including patient response variability, body composition changes, and the need for novel biological targets. He also shares Eli Lilly's innovative CRISPR-based approach for rapid target validation in obesity research. This talk offers valuable insights into the future of obesity medicine, discussing both the promise and challenges of developing more effective, personalized treatments for metabolic disease.
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Weight loss can be a challenging journey for many individuals struggling with obesity or excess body weight. From strict diet plans to rigorous workout routines, finding an effective and sustainable solution can seem like an uphill battle. However, with the development of medical treatments such as semaglutide, weight loss success stories have become more attainable for those looking to improve their health and well-being.
Success Story #1: Emily’s Transformation
Emily, a 35-year-old mother of two, had been struggling with her weight for years. Despite trying various diets and exercise programs, she could never seem to shed the extra pounds. That’s when she decided to try semaglutide after hearing about its potential for weight loss. Within just a few months of starting the treatment, Emily began to see dramatic changes in her body. Not only did she lose weight, but she also noticed improvements in her energy levels and overall health. Today, Emily is proud to share her success story and inspire others to take control of their weight.
Success Story #2: John’s Journey to Better Health
John, a 45-year-old man with a family history of obesity, knew he needed to make a change for his health. After consulting with his doctor, he decided to incorporate semaglutide into his weight loss plan. The results were impressive – John lost over 50 pounds in just six months and was able to reduce his risk of developing weight-related health issues. With the support of his healthcare team and the power of semaglutide, John was able to transform his life and set a positive example for his loved ones.
Success Story #3: Sarah’s Sustainable Weight Loss
Sarah, a 28-year-old professional with a busy schedule, struggled to find a weight loss solution that fit her lifestyle. After hearing about the benefits of semaglutide, she decided to give it a try. What sets semaglutide apart is its ability to not only help individuals lose weight but also maintain their results long-term. Sarah experienced steady and sustainable weight loss over the course of a year, all while juggling her work commitments and social life. Thanks to semaglutide, Sarah was able to achieve her weight loss goals without sacrificing her quality of life.
Success Story #4: Michael’s Motivation to Change
Michael, a 50-year-old retiree, had struggled with his weight for most of his adult life. After experiencing a health scare, he knew it was time to make a serious commitment to his well-being. With the help of semaglutide, Michael was able to jumpstart his weight loss journey and rediscover his motivation to change. Not only did he lose weight and improve his physical health, but he also regained confidence and a sense of purpose. Today, Michael continues to maintain his weight loss through a balanced diet, regular exercise, and ongoing support from his healthcare provider.
Success Story #5: Laura’s Lifestyle Transformation
Laura, a 30-year-old fitness enthusiast, was shocked when she started to gain weight despite her healthy habits. Frustrated and discouraged, she turned to semaglutide as a last resort. To her surprise, the treatment not only helped her lose weight but also taught her valuable lessons about balance and self-care. With the support of semaglutide, Laura was able to transform her lifestyle and mindset around food and exercise. Today, she maintains a healthy weight and enjoys a vibrant and fulfilling life, thanks to the power of semaglutide.
Weight loss success stories like these are a reminder that with dedication, support, and the right tools, achieving a healthier body and mind is possible. Semaglutide offers a promising solution for individuals looking to kickstart their weight loss journey and build a foundation for long-term success. If you’re considering semaglutide as a weight loss option, consult with your healthcare provider to determine if it’s the right choice for you.
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We dive into the controversial theories surrounding weight loss and government influence. Are these claims about 'controlled opposition' genuine, or just conspiracy? Join us as we explore the reality behind the rumors and the impact of public perception. #ConspiracyTheories #WeightLossJourney #ControlledOpposition #GovernmentInfluence #TruthRevealed #PublicPerception #HealthyDebate #FitnessMyths #RealVsFake #SocialMediaCulture
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Weekly Weigh-In: Christopher Hits His Goal! 🎉 98 lbs Down! + Laraine’s 52.4lb Loss! It’s a HUGE week on The Downsized! 🎉 Christopher has officially hit his weight loss goal for the first time and is now 98 lbs down! 🙌 Meanwhile, Laraine continues her amazing progress with 52.4 lbs lost on her GLP-1 adventure! 🚀 We’re breaking down: ✅ Christopher’s journey to 98 lbs lost and what it feels like to finally hit his goal ✅ Laraine’s continued success at 52.4 lbs down ✅ What’s next for both of us as we continue life with Zepbound, Mounjaro, and compounded tirzepatide ➡️ If you're new to our channel, we’ve lost over 150 lbs together using GLP-1s, and we share the real, raw truth of the adventure every week. 💬 Drop your wins (or struggles) in the comments—we’re all in this together! 🚢 JOIN US ON THE DOWNSIZED AT SEA CRUISE! 🚢 We’d love for you to be part of this incredible adventure! Imagine sailing the Caribbean, meeting other GLP-1 adventurers, and sharing this experience together. It’s going to be an unforgettable trip, and we’d love to see you there! More details coming soon—stay tuned! 🔔 Like, subscribe, and turn on notifications so you don’t miss a weigh-in! We use Mochi Health: https://joinmochi.com/. Use Laraine’s code for $40 off: QIYGO8. BOOK THE DOWNSIZED AT SEA CRUISE: https://thedownsized.org/downsized-at-sea-2025/ DOWNSIZED WEBSITE: https://thedownsized.org/ JOIN CLUB DOWNSIZED: https://www.youtube.com/@thedownsized/join DOWNSIZED GLP-1 COMPANION PRODUCT STORE: https://thedownsized.org/downsized-store
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Understanding Wegovy & Zepbound Non-Response - When Weight Loss Meds Don't Work If you need assistance in your journey to reach your weight loss goals, book a consultation with me: https://calendly.com/drdanburton/weight-loss-consult Join this channel to get access to perks: https://www.youtube.com/channel/UCnQiofnuXFcloJRoJTsc1FQ/join Download my FREE GLP-1/GIP Medication Information Sheet and 7-Day Food Journal: http://eepurl.com/gdB2qn Try my fancy dancy Total Daily Energy Expenditure (TDEE) Calculator: https://healthevolved.co/tdee-calculator/ Subscribe to the channel: https://www.youtube.com/@theofficialdrdan?sub_confirmation=1 – If you've been taking Wegovy or Zepbound and aren't seeing the weight loss you expected, you're not alone. Let's dive into why some people don't respond to these medications the way they hope. Success in weight loss is generally defined as losing 5% or more of your baseline weight. But studies like STEP-1 and SURMOUNT-1 show that 10-15% of people on these meds don't reach that benchmark. In my clinical practice, I see similar outcomes, and many of you have shared your experiences of not responding to these medications in the comments of my videos. There are several reasons why this happens. I categorize non-responders into three groups: True Non-Responders, Slow Responders, and Quick Fix Seekers. True Non-Responders might not experience any appetite suppression, possibly due to genetics or individual physiology. Switching medications might help, but for some, it may take a new drug to see results. Slow Responders do lose weight, but at a slower pace. This could be due to factors like medical conditions, side effects, or inconsistent lifestyle changes. They might lose 1-2 pounds a month instead of 4-8, and that slower progress can be discouraging. Quick Fix Seekers have unrealistic expectations, expecting rapid weight loss or miracles from the medication alone without significant lifestyle changes. This group often needs more education and a shift in mindset. Remember, these medications are tools to help you on your weight loss journey. They can make things easier, but they aren't a magic fix. Consistency and patience are key. So keep going, stay consistent, and remember that this is a long-term journey, not a quick fix. Thanks for watching and always remember: small tweaks lead to massive peaks! - Dr. Dan – Watch my previous videos about how to fight obesity and about the best medicine for weight loss: ▪️ Watch This Before Taking Mounjaro: https://youtu.be/BmkVtGgejhk ▪️ From Ozempic to Mounjaro: https://youtu.be/L9e46iFWwIs ▪️ Muscle Loss with Ozempic, Wegovy & Mounjaro: https://youtu.be/lnEH-v64aG0 ▪️ Managing Nausea from Ozempic, Wegovy and Trulicity!: https://youtu.be/3R1Fwhf02LE ▪️ Ozempic: Stomach Paralysis Update: https://youtu.be/MPyROywaM0g ▪️ How to Switch from Ozempic (or Wegovy) to Mounjaro: https://youtu.be/L9e46iFWwIs ▪️ Ozempic Paralyzed My Stomach: https://youtu.be/tj9thkkN5aM ▪️ How to Inject Mounjaro: step-by-step tutorial: https://youtu.be/piVHr7UqYDg Products I recommend to support your weight-loss journey: ▪️ Managing Constipation: https://amzn.to/4bs0g3h ▪️ Managing Diarrhea: https://amzn.to/3UUjNCm ▪️ Managing Heartburn: https://amzn.to/3Vbfx31 ▪️ Internalized Weight Bias: https://amzn.to/4avCpP3 ▪️ Protein Bars: https://amzn.to/3RiItUr ▪️ Scales and More: https://amzn.to/4bNJDPc ▪️ Supplements: https://amzn.to/44TgobJ ▪️ Activity Trackers I recommend: https://amzn.to/4dOYLOa ▪️ My favorite Books: https://amzn.to/3Kb0VKt 🇺🇸 USA: https://amzn.to/3RC7MSd 🇨🇦 Canada: https://amzn.to/45gq4vg – Live in Alberta? Come see me at my Pharmacist-led Obesity Clinic at Apothecare Pharmacy - http://apothecarerx.ca – Sign up for my newsletter: http://eepurl.com/gdB2qn – Contact Me: [email protected] – For more about weight loss via habit mastery, visit https://www.healthevolved.co Join me on social media: ▪️ https://www.facebook.com/theofficialdrdan ▪️ https://www.instagram.com/theofficialdrdan Disclaimer of Medical Liability. HEALTHCARE EVOLUTION INC. DOES NOT PROVIDE MEDICAL ADVICE. The content of this material is for general informational purposes only. The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Reliance on any information provided here is solely at your own risk. Individual medical needs are very different; you should not assume that the information in this document concerning certain courses of treatment or outcomes will apply to you. Rather, you should evaluate your medical condition and make treatment decisions based upon consultation with your physician. #Wegovy #WeightLoss #Obesity
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