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Are you on Ozempic, Wegovy, Mounjaro, or Zepbound—and wondering how to actually keep the weight off for good? You’re in the right place.
There’s a lot of hype, misinformation, and even shame around GLP-1 weight loss medications. Some people swear by them. Others criticize them. And then there’s the BIG question: What happens when you stop taking them?
Here’s the truth: These drugs are a tool, not a magic fix. And if you’re not making key lifestyle changes while using them, you’re setting yourself up for weight regain the moment you come off.
In this video, I’m breaking it ALL down:
✅ The biggest mistakes people make on these medications
✅ Why muscle loss, metabolism slowdowns, and nutrient deficiencies are a REAL risk
✅ The 5 key steps my most successful clients follow to keep weight off long-term
✅ How to manage side effects like nausea, constipation, and fatigue
✅ What you need to do NOW to make sure your weight loss is sustainable
If you’re taking Ozempic, Mounjaro, Wegovy, or Zepbound—or thinking about it—this video will help you avoid the yo-yo dieting cycle and make the most of your journey.
💬 Comment Below: Are you on one of these medications? What’s been your biggest challenge? Let’s talk!
🎯 Ready for expert guidance & a personalized plan? Book a FREE coaching call with me: https://calendly.com/ericaouderland/30min
🔔 Subscribe for weekly coaching on sustainable weight loss & body confidence: @supermamamindbody
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In this episode, my guest is Dr. Zachary Knight, Ph.D., a professor of physiology at the University of California, San Francisco (UCSF), and Howard Hughes Medical Institute (HHMI) investigator. We discuss how the brain controls our sense of hunger, satiety, and thirst. He explains how dopamine levels impact our cravings and eating behavior (amount, food choices, etc) and how we develop and can change our food preferences and adjust how much we need to eat to feel satisfied. We discuss factors that have led to the recent rise in obesity, such as interactions between our genes and the environment and the role of processed foods and food combinations. We also discuss the new class of medications developed for the treatment of obesity and diabetes, including the GLP-1 agonists semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro). We discuss how these medications work to promote weight loss, the source of their side effects, and the newer compounds soon to overcome some of those side effects, such as muscle loss. Dr. Knight provides an exceptionally clear explanation for our sense of hunger, thirst, and food cravings that translates to practical knowledge to help listeners better understand their relationship to food, food choices, and meal size to improve their diet and overall health. Access the full show notes, including referenced articles, books, people mentioned, and additional resources: https://www.hubermanlab.com/episode/dr-zachary-knight-the-science-of-hunger-medications-to-combat-obesity Thank you to our sponsors AG1: https://drinkag1.com/huberman BetterHelp: https://betterhelp.com/huberman Eight Sleep: https://eightsleep.com/huberman Waking Up: https://wakingup.com/huberman LMNT: https://drinklmnt.com/huberman Huberman Lab Social & Website Instagram: https://www.instagram.com/hubermanlab Threads: https://www.threads.net/@hubermanlab Twitter: https://twitter.com/hubermanlab Facebook: https://www.facebook.com/hubermanlab TikTok: https://www.tiktok.com/@hubermanlab LinkedIn: https://www.linkedin.com/in/andrew-huberman Website: https://www.hubermanlab.com Newsletter: https://www.hubermanlab.com/newsletter Dr. Zachary Knight UCSF academic profile: https://profiles.ucsf.edu/zachary.knight HHMI profile: https://www.hhmi.org/scientists/zachary-knight Publications: https://knightlab.ucsf.edu/publications Lab website: https://knightlab.ucsf.edu X: https://x.com/zaknight Instagram: https://www.instagram.com/zknightsf LinkedIn: https://www.linkedin.com/in/zachary-knight-29a37977 Timestamps 00:00:00 Dr. Zachary Knight 00:02:38 Sponsors: BetterHelp, Helix Sleep & Waking Up 00:07:07 Hunger & Timescales 00:11:28 Body Fat, Leptin, Hunger 00:17:51 Leptin Resistance & Obesity 00:20:52 Hunger, Food Foraging & Feeding Behaviors, AgRP Neurons 00:30:26 Sponsor: AG1 00:32:15 Body Weight & Obesity, Genes & POMC Neurons 00:39:54 Obesity, Genetics & Environmental Factors 00:46:05 Whole Foods, Ultra-Processed Foods & Palatability 00:49:32 Increasing Whole Food Consumption, Sensory Specific Satiety & Learning 00:58:55 Calories vs. Macronutrients, Protein & Salt 01:02:23 Sponsor: LMNT 01:03:58 Challenges of Weight Loss: Hunger & Energy Expenditure 01:09:50 GLP-1 Drug Development, Semaglutide, Ozempic, Wegovy 01:19:03 GLP-1 Drugs: Muscle Loss, Appetite Reduction, Nausea 01:23:24 Pharmacologic & Physiologic Effects; GLP-1 Drugs, Additional Positive Effects 01:30:14 GLP-1-Plus Development, Tirzepatide, Mounjaro, AMG 133 01:34:49 Alpha-MSH & Pharmacology 01:40:41 Dopamine, Eating & Context 01:46:01 Dopamine & Learning, Water Content & Food 01:53:23 Salt, Water & Thirst 02:03:27 Hunger vs. Thirst 02:05:46 Dieting, Nutrition & Mindset 02:09:39 Tools: Improving Diet & Limiting Food Intake 02:14:15 Anti-Obesity Drug Development 02:17:03 Zero-Cost Support, Spotify & Apple Follow & Reviews, YouTube Feedback, Social Media, Neural Network Newsletter #HubermanLab #Health #Obesity Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com Disclaimer: https://www.hubermanlab.com/disclaimer
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#healthylifestyle #mounjaro #thepatricedenise #zepbound Three Months on Mounjaro! I took my 1st injection on November 30, 2022 and weighed in at 191.4 lbs. ❤️I continue to lose weight steadily and my fasting blood sugar levels are trending downward, into levels that I haven't seen in FOREVER!!❤️ Renpho Measuring Tape: https://amzn.to/3SK797P 📝Metabolic Syndrome is a cluster of conditions that occur together, increasing your risk of heart disease, stroke and type 2 diabetes. These conditions include increased blood pressure, high blood sugar, excess body fat around the waist, and abnormal cholesterol or triglyceride levels. It's also linked to a condition called insulin resistance. ---The National Institutes of Health guidelines define metabolic syndrome as having three or more of the following traits, including traits for which you may be taking medication to control: - Large waist - A waistline that measures at least 35 inches (89 centimeters) for women and 40 inches (102 centimeters) for men - High triglyceride level - 150 milligrams per deciliter (mg/dL), or 1.7 millimoles per liter (mmol/L), or higher of this type of fat found in blood - Reduced "good" or HDL cholesterol - Less than 40 mg/dL (1.04 mmol/L) in men or less than 50 mg/dL (1.3 mmol/L) in women of high-density lipoprotein (HDL) cholesterol - Increased blood pressure - 130/85 millimeters of mercury (mm Hg) or higher - Elevated fasting blood sugar - 100 mg/dL (5.6 mmol/L) or higher https://www.mayoclinic.org/diseases-conditions/metabolic-syndrome/symptoms-causes/syc-20351916 ----------------------------------------------------------------------------------------------------------------------------------- Join me on this journey to healthier living and conquering diabetes! Like👍🏽, Share, and Subscribe to enjoy more videos! Hit the notification bell 🔔to always be notified when I upload a new video! Thanks for watching❤️! ✅Business Inquiries: [email protected] 🎶all MUSIC🎶provided by Epidemic Sound. Click here to sign up: https://share.epidemicsound.com/gectix 📸Camera 📸used to film: https://amzn.to/3JxsaQf My Amazon Storefront: https://www.amazon.com/shop/patricedenise ✅ The description may contain affiliate links, which means that if you click on one of the product links and make a purchase, I may receive a small commission, which does not increase the cost to you. This helps support the channel! Thanks for the support! 🔸🔸🔸Let's Stay Connected🔸🔸🔸 🔸INSTAGRAM - https://www.instagram.com/the.patrice.denise/ 🔸TIKTOK - @the.patrice.denise ___________________________________________________________________________________ Disclaimer - All thoughts mentioned are my own. Always consult your healthcare provider for medical advice or before implementing any changes to your diet or lifestyle. ___________________________________________________________________________________ Don't forget to like, comment, subscribe and turn on your notification bell! #mounjaro #mounjarojourney #tirzepatide #semaglutide #diabetes #type2diabetes #type2diabetessymptoms #livinglifewiththepatricedenise #daysinmylife #weightlossjourney #weeklyvlog #healthjourney #healthylifestyle #healthy #weightloss #weeklyvlog #weightlosstips #fitnessvlog #bloodsugarmonitoring #bloodsugar #ozempic #wegovy #saxenda #healthyjourney #glucose #glucosemonitoring #bloodsugar #elililly #trulicity #dulaglutide #liraglutide #NovoNordisk #mounjaroweightloss #thepatricedenise #vsg
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#AchievingHealthGoals: Sharon Osbourne's Inspiring Weight Loss Journey #OzempicTransforms #SmartChoicesForPersonalWellness #RealResultsThroughLifestyleChanges #SharonOsbourne #WeightLoss #Ozempic #HealthStruggles #BodyImage #EatingDisorder #WeightLossJourney #MentalHealth #CelebrityWellness #PersonalChoices #GastricSleeveSurgery #PublicDiscussion #CelebrityHealth #WellBeing #BodyPositivity #MediaPressure Medications and Sharon Osbourne's Weight Loss: An Open Letter In a recent interview, Sharon Osbourne discussed her battles with obesity and how the weight loss drug Ozempic helped her reach a weight below 100 pounds. The 71-year-old TV actress broke her weight loss silence, saying she is "too gaunt" and has shed 42 pounds. Based on what Osbourne said, she began taking Ozempic in December of 2022. The drug was originally prescribed for diabetes but is now used for weight loss. She warned against the use of the medication, particularly among teens, because of the risk of addiction and stressed that she has been off it for some time. A former judge on "X Factor" made it clear that she doesn't care what others think of her looks, saying, "I don't care what people say about the way I look." She made note of her frail appearance and stressed that she has intentionally chosen her body type and how it appears. Among Sharon Osbourne's many strategies for controlling her weight, including bariatric surgery, is her history of candor about her battles with an eating disorder. The mental side of her challenges was highlighted by her description of how her quest for control has affected her relationship with food. Osbourne wants to keep a healthy balance and not go too thin, even if she lost a lot of weight recently. Similarly, Kelly Osbourne, who is her daughter's health advocate, has been forthright about her plans to have gastric sleeve surgery in 2020. News of Sharon Osbourne's weight loss just adds fuel to the fire of public debates about healthy eating, self-esteem, and the influence of celebrities.
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