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Ketogenic therapy, commonly in the form of a keto diet, is often known for having more “side benefits” than “side effects.” However, it is a powerful medical intervention and, as such, not entirely without risks. In some instances, individuals transitioning onto a keto diet to treat a mental health condition, like bipolar or schizophrenia, can experience symptoms of hypomania. There are many strategies to increase the safety of keto and mitigate potential risks, including slowly easing into a ketogenic diet, monitoring sleep, having a bridge medication available, and always having expert guidance from a clinical care team. In this interview, Dr. Bret Scher discusses the risk of hypomania with two experts in the metabolic psychiatry field: Harvard-trained psychiatrist and author of the groundbreaking book, Change Your Diet, Change Your Mind, Dr. Georgia Ede, and Nicole Laurent, LMHC, a counselor who trains non-prescribers on assisting patients with ketogenic therapy. According to Dr. Ede, hypomania and other unwanted psychiatric symptoms are uncommon when implementing ketogenic therapy. She recommends that people not allow these risks to dissuade them from trying this form of treatment. Featured in this video: Georgia Ede, MD https://www.diagnosisdiet.com/ Twitter: @georgiaedemd Order Change Your Diet, Change Your Mind: https://www.diagnosisdiet.com/change-your-diet-change-your-mind Nicole Laurent, LMHC https://www.mentalhealthketo.com Twitter @KetoCounselor Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry. Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/ About us: Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them. Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications. Timestamps 0:00 Introduction 2:38 How often does hypomania occur with ketosis? 3:55 What the science says about a ketosis causing hypomania 5:03 Signs of hypomania to look for 6:14 How quickly should you transition to a keto diet? 7:54 Using bridge medications while transitioning to keto 10:25 Talking to your doctor about ketogenic therapy 11:49 Conclusion #MetabolicMind #KetoForMentalHealth #MetabolicPsychiatry #BipolarDisorder #MetabolicNeuroscience #KetogenicMetabolicTherapy #NutritionalKetosis #MentalIllness #AlternativeTreatment #Obesity #MedicationSideEffects #Schizophrenia #Hypomania

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In this episode of "In the Interim..." we revisit the ground-breaking seamless phase 2/3 clinical trial for the GLP-1 agonist, dulaglutide—better known as Trulicity. We discuss the intricacies of the adaptive trial design, and the unique features that helped expedite development by 12-18 months. Listeners will gain insight into how Bayesian algorithms and innovative statistical methods were pivotal in navigating a complex trial design, benefiting Eli Lilly's pipeline and changing the landscape of diabetes treatment. Key Highlights: —Outline of the trial design and the barriers faced during its inception in 2007-2008. —Explanation of the Clinical Utility Index and its role in adaptive randomization. —The DSMB's role and interaction with Bayesian decision-making models. —Simulation-based design to optimize development efficiencies. —Insights into the predictive power of the trial on weight loss outcomes in subsequent trials. Quotes: —"The trial was run entirely by Bayesian algorithms." – Scott Berry —"They believed this utility function was absolutely the right way to go forward." – Scott Berry For more head to berryconsultants.com.

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Get LMNT Electrolytes & Receive a FREE Sample Flavors Pack: http://drinklmnt.com/thomas The Best Cardio Zone to Burn Stubborn Belly Fat This video does contain a paid partnership with a brand that helps to support this channel. It is because of brands like this that we are able to provide the content that we do for free. Click HERE to Subscribe: https://www.youtube.com/c/ThomasDeLauerOfficial?sub_confirmation=1 Please check out the new Shorts channel, DeLauer Clips and Workouts, here: https://www.youtube.com/channel/UCQPQImPsw74KhO0Zy2-leyA/videos Please Subscribe to my Email Newsletter Here: https://www.thomasdelauer.com/life-optimization-tactics/ Follow More of My Daily Life on Instagram: http://www.Instagram.com/ThomasDeLauer References https://www.hindawi.com/journals/jobe/2014/834865/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999698/ https://journals.physiology.org/doi/full/10.1152/japplphysiol.00030.2001?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2290107/ https://pubmed.ncbi.nlm.nih.gov/35522254/ https://www.sciencedirect.com/science/article/pii/S2666337619300034 Timestamps ⏱ 0:00 - Intro - Cardio Zones 1-5 Breakdown 0:31 - Zone 1 3:12 - Zone 2 5:28 - Get LMNT Electrolytes & Receive a FREE Sample Flavors Pack! 6:01 - Zone 3 8:35 - Zone 4 11:05 - Zone 5 12:47 - Recap & Suggestions

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