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Inhibitors of dipeptidyl peptidase 4 (DPP-4 inhibitors or gliptins) are a class of oral hypoglycemics that block the enzyme dipeptidyl peptidase-4 (DPP-4). They can be used to treat diabetes mellitus type 2. The first agent of the class – sitagliptin – was approved by the FDA in 2006.[1] Glucagon increases blood glucose levels, and DPP-4 inhibitors reduce glucagon and blood glucose levels. The mechanism of DPP-4 inhibitors is to increase incretin levels (GLP-1 and GIP),[2][3][4] which inhibit glucagon release, which in turn increases insulin secretion, decreases gastric emptying, and decreases blood glucose levels. A 2018 meta-analysis found no favorable effect of DPP-4 inhibitors on all-cause mortality, cardiovascular mortality, myocardial infarction or stroke in patients with type 2 diabetes.[5] ExamplesEdit Drugs belonging to this class are: Sitagliptin[6] (FDA approved 2006, marketed by Merck & Co. as Januvia) Vildagliptin[7] (EU approved 2007, marketed in the EU by Novartis as Galvus) Saxagliptin (FDA approved in 2009, marketed as Onglyza) Linagliptin (FDA approved in 2011, marketed as Tradjenta by Eli Lilly and Company and Boehringer Ingelheim)[8] Gemigliptin (approved in Korea in 2012, marketed by LG Life Sciences)[9] Marketed as Zemiglo Anagliptin (approved in Japan in 2012, marketed by Sanwa Kagaku Kenkyusho Co., Ltd. and Kowa Company, Ltd.)[10] Teneligliptin (approved in Japan in 2012[11]) Alogliptin (FDA approved 2013, marketed by Takeda Pharmaceutical Company) Trelagliptin (approved for use in Japan in 2015) Omarigliptin (MK-3102) (approved in Japan in 2015,[12] developed by Merck & Co.; research showed that omarigliptin can be used as once-weekly treatment and generally well-tolerated throughout the base and extension studies[13]) Evogliptin (approved for use in South Korea[14]) Gosogliptin (approved for use in Russia[15]) Dutogliptin (being developed by Phenomix Corporation), Phase III[16] Other chemicals which may inhibit DPP-4 include: Berberine, an alkaloid found in plants of the genus Berberis, inhibits dipeptidyl peptidase-4 which may at least partly explains its antihyperglycemic activity.[17] Adverse effectsEdit In those taking sulphonylureas, there is an increased risk of low blood sugar.[18] Adverse effects, including nasopharyngitis, headache, nausea, heart failure, hypersensitivity and skin reactions. The U.S. Food and Drug Administration (FDA) is warning that the type 2 diabetes medicines like sitagliptin, saxagliptin, linagliptin, and alogliptin may cause joint pain that can be severe and disabling. FDA has added a new Warning and Precaution about this risk to the labels of all medicines in this drug class, called dipeptidyl peptidase-4 (DPP-4) inhibitors.[19] However, studies assessing risk of rheumatoid arthritis among DPP-4 inhibitor users have been inconclusive.[20] A 2014 review found increased risk of heart failure with saxagliptin and alogliptin, prompting the FDA in 2016 to add warnings to the relevant drug labels.[21] A 2018 meta analysis showed that use of DPP-4 inhibitors was associated with a 58% increased risk of developing acute pancreatitis compared with placebo or no treatment.[22] A 2018 observational study suggested an elevated risk of developing inflammatory bowel disease (specifically, ulcerative colitis), reaching a peak after three to four years of use and decreasing after more than four years of use.[23] CancerEdit In response to a report of precancerous changes in the pancreases of rats and organ donors treated with the DPP-4 inhibitor sitagliptin,[24][25] the United States FDA and the European Medicines Agency each undertook independent reviews of all clinical and preclinical data related to the possible association of DPP-4 inhibitors with pancreatic cancer. In a joint letter to the New England Journal of Medicine, the agencies stated that they had not yet reached a final conclusion regarding a possible causative relationship.[26] A 2014 meta-analysis found no evidence for increased pancreatic cancer risk in people treated with DPP-4 inhibitors, but owing to the modest amount of data available, was not able to completely exclude possible risk.[27] Combination drugsEdit Some of the DPP-4 inhibitor drugs have gotten approval from the FDA to be used with metformin concomitantly with additive effect to increase the level of glucagon-like peptide 1 (GLP-1) which also decreases hepatic glucose production.[28]

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Are your medications doing more harm than good? Is it possible that the conventional wisdom surrounding medication usage needs to be reevaluated? In this eye-opening podcast, we delve into the controversial topic of deprescribing and question whether certain medications are truly beneficial in the long run. “Change your food, change your life!” Dr. Eric Westman and his Adapt Your Life Academy team are on a mission to empower people around the world to transform their health through the science-backed benefits of low-carbohydrate and ketogenic diets. Dr. Westman is an obesity medicine specialist and trusted expert in the therapeutic power of carbohydrate restriction, and clinical research, and has treated patients using low-carb keto diets for over twenty-five years. He makes keto SIMPLE, so that YOU can LOSE weight, REVERSE chronic disease and GET the RESULTS you want. Get started NOW by grabbing our FREE GUIDE – 10 Tips for Starting Keto Right. 👉 https://adaptyourlifeacademy.com/start-keto-right-bonus/ Visit our website to see all the online, self-paced courses we offer on keto diets, low-carb cooking, diabetes, cancer, mobility, and more: 👉 https://adaptyourlifeacademy.com/all-courses/ Adapt Your Life Academy Online Courses: https://adaptyourlifeacademy.com/all-courses/ Bestselling Book – END YOUR CARB CONFUSION: https://www.amazon.com/Your-Carb-Confusion-Eric-Westman END YOUR CARB CONFUSION COOKBOOK: https://www.amazon.com/End-Your-Carb-Confusion FREE QUIZ to determine your personal carb threshold: https://adaptyourlifeacademy.com/carb-threshold-bonus/ Dr. Eric Westman, Associate Professor of Medicine at Duke. He is Board Certified in Obesity Medicine & Internal Medicine, & founded the Duke Keto Medicine Clinic. He is a Fellow in The Obesity Society. He is the author of The New Atkins for a New You, Cholesterol Clarity, and Keto Clarity, and End Your Carb Confusion & co-founder of Adapt Your Life. Disclaimer: Nothing on our channel is medical advice. Dr. Westman and the Adapt Your Life team do not diagnose, treat, cure, or prevent any medical conditions online. We provide education to help people better understand their own health and support their well-being. Make sure you are working with YOUR licensed provider to monitor your health and medications. These posts and videos are not designed to and do not provide medical advice, professional diagnosis, opinion, treatment, or services to you or to any other individual. We do not promote or endorse affiliate links and/or products unless they are our own.

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Weight loss Daliya Tofu Salad Ingredients: Daliya (raw) – 50g (boiled) Onion – 40g (finely chopped) Tomato – 40g (chopped) Cucumber – 100g (diced) Tofu – 100g (cubed) Green chilli – 1 (finely chopped) Fresh coriander – a handful (chopped) For the Dressing: Juice of half a lemon Chaat masala – to taste Chilli flakes – to taste Black salt – to taste Mint powder – a pinch Black pepper – to taste Instructions: In a mixing bowl, add the boiled daliya. Add chopped onion, tomato, cucumber, green chilli, and tofu. In a separate bowl, mix all the dressing ingredients. Pour the dressing over the salad and mix everything well. Add fresh coriander, give it a final mix, and serve immediately. Weight gain Jaggery Daliya Bowl Ingredients: Daliya (raw) – 50g (boiled) Full cream milk – 200ml (warm or room temperature) Jaggery – 50g (grated or chopped) Almonds – 10g (chopped) Peanut butter – 30g Instructions: In a bowl, add the boiled daliya. Pour in the milk and stir gently. Add jaggery and peanut butter mix until smooth and creamy. Top with chopped almonds, mix again, and enjoy

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Shark Tank BHB Keto: The Breakthrough Episode on Ketones and Weight Loss

Introduction

Shark Tank, the popular television show where entrepreneurs pitch their ideas to potential investors, recently featured a groundbreaking episode on BHB Keto supplements for weight loss. The episode highlighted the growing trend of using ketones to achieve rapid and effective weight loss results. This breakthrough in the world of diet and nutrition has caught the attention of millions of viewers, sparking a new wave of interest in ketosis and its benefits.

What is BHB Keto?

BHB Keto, short for Beta-Hydroxybutyrate, is a type of ketone body that is produced by the liver during periods of fasting or low-carbohydrate intake. Ketones are used by the body as an alternative fuel source when glucose levels are low, leading to a metabolic state known as ketosis. BHB Keto supplements are designed to help the body enter ketosis more quickly and easily, allowing for faster fat burning and weight loss.

How Does BHB Keto Work?

When you consume BHB Keto supplements, your body is flooded with exogenous ketones that mimic the effects of natural ketosis. This accelerates the process of fat burning, as your body begins to use stored fat for energy instead of glucose. By increasing the levels of ketones in your bloodstream, BHB Keto helps suppress appetite, regulate blood sugar levels, and improve mental clarity and focus. This powerful combination of benefits makes BHB Keto a popular choice for those looking to lose weight and improve their overall health.

The Shark Tank Episode

The Shark Tank episode on BHB Keto featured several entrepreneurs who have developed innovative products based on the principles of ketosis. The investors were impressed with the scientific research behind BHB Keto supplements and the success stories of individuals who have achieved significant weight loss results. Each entrepreneur presented their unique spin on BHB Keto, from tasty ketone-infused drinks to convenient on-the-go snacks. The Sharks were eager to get in on the action and invest in the future of ketones and weight loss.

Benefits of BHB Keto

There are numerous benefits to incorporating BHB Keto supplements into your weight loss regimen. In addition to promoting rapid fat burning and weight loss, BHB Keto helps increase energy levels, improve athletic performance, and enhance mental focus. By supporting the body’s natural ketone production, BHB Keto can also help reduce inflammation, lower cholesterol levels, and stabilize blood sugar. With all of these positive effects, it’s no wonder that BHB Keto is gaining popularity as a safe and effective way to achieve your weight loss goals.

Summary

In conclusion, the Shark Tank episode on BHB Keto brought ketones and weight loss to the forefront of the health and wellness industry. With its ability to promote rapid fat burning, increase energy levels, and improve overall health, BHB Keto supplements are a game-changer for those looking to achieve their weight loss goals. Whether you’re a fitness enthusiast or simply looking to shed a few pounds, BHB Keto offers a safe and effective solution to help you reach your desired weight and improve your quality of life.

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This short briefly explains how GLP 1 Agonists can help people over 40 that are struggling to lose weight

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Pharmacist Review of Victoza (Liraglutide), addressing the side effects of Victoza, Use of Victoza in weight loss or weight management, as well as precautions or warnings relating to Victoza and the risks of thyroid cancer. 0:00 Introduction 0:39 Description & Uses 3:02 Hypoglycemia 3:36 GI Side Effects 4:19 Other Side Effects 6:05 Weight Loss