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Welcome back to the CardioNerds Cardiovascular Prevention Series, where we are continuing our discussion of Glucagon-like Peptide-1 Receptor Agonists (GLP-1 RAs). This class of medications is becoming a household name, not only for their implications for weight loss but also for their effect on cardiovascular disease. CardioNerds Dr. Ty Sweeney (CardioNerds Academy Faculty Member and incoming Cardiology Fellow at Boston Medical Center), Dr. Rick Ferraro (CardioNerds Academy House Faculty and Cardiology Fellow at Johns Hopkins Hospital), and special guest Dr. Franck Azobou (Cardiology Fellow at UT Southwestern) sat down with Dr. Darren McGuire (Cardiologist at UT Southwestern and Senior Editor of Diabetes and Vascular Disease Research) to discuss important trial data on GLP-1 RAs in patients with heart disease, as well as recent professional society guidelines on their use. Show notes were drafted by Dr. Ty Sweeney. Audio editing was performed by CardioNerds Intern student Dr. Diane Masket. If you haven’t already, be sure to check out CardioNerds episode #350 where we discuss the basics and mechanism of action of GLP-1 RAs with Dr. Dennis Bruemmer. This episode was produced in collaboration with the American Society of Preventive Cardiology (ASPC) with independent medical education grant support from Novo Nordisk. See below for continuing medical education credit. Claim CME for this episode HERE. CardioNerds Prevention PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls and Quotes - GLP-1 Agonists: Diving into the Data Patients with diabetes and clinical atherosclerotic cardiovascular disease (ASCVD) or who are at high risk of ASCVD benefit from treatment with a GLP-1 RA. For persons with sufficient ASCVD risk and type 2 diabetes, GLP-1 RAs and SGLT2 inhibitors can, and often should, be used in combination. "Just like we don’t consider ‘and/or’ for the four pillars of guideline-directed medical therapy for heart failure with reduced ejection fraction, we shouldn’t parcel out these two therapeutic options...it should be both.” Setting expectations with your patients regarding injection practices, side effects, and expected benefits can go a long way toward improving the patient experience with GLP-1 RAs. Utilize a multidisciplinary approach when caring for patients on GLP-1 RAs. Build a team with your patient’s primary care provider, endocrinologist, clinical pharmacist, and nurse. “This is really a cardiologist issue. These are no longer endocrinology or primary care drugs. We need to be prescribing them ourselves just like we did back in the nineties when we took over the statin prescriptions from the endocrinology domain...we need to lead the way.” Show notes - GLP-1 Agonists: Diving into the Data For which patients are GLP-1 RAs recommended to reduce the risk of major cardiac events? For patients with type 2 diabetes and ASCVD, starting a GLP-1 RA carries a Class 1, Level of Evidence A recommendation in the most recent ESC and ACC guidelines. For patients without diabetes or clinical ASCVD with an estimated 10-year risk of CVD exceeding 10%, consideration of starting a GLP-1 RA carries a Class 2b, Level of Evidence C recommendation to reduce CV risk. The STEP-HFpEF trial showed that among patients with obesity and HFpEF, once-weekly semaglutide may be beneficial in terms of weight loss and quality of life. The results of the FIGHT and LIVE trials question the utility and safety of liraglutide in treating patients with advanced HFrEF. Of the over 17,000 patients enrolled in the SELECT trial, about 25% had heart failure, of which about one-third had HFrEF. Stay tuned for sub-analyses from that trial for more info! Can we still prescribe GLP-1 Ras in patients with well-controlled T2DM?
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Apple Cider Vinegar (ACV) has been gaining popularity as a health supplement in recent years, with many people touting its numerous health benefits. One of the most convenient and popular ways to consume ACV is through gummies. ACV gummies offer a more palatable and easier way to incorporate this powerful ingredient into your daily routine. In this article, we will explore the health benefits of ACV gummies and their potential for weight loss.
Antioxidant Properties
ACV is known for its high antioxidant content, which can help protect cells from damage caused by free radicals. Antioxidants play a crucial role in reducing inflammation and preventing chronic diseases such as heart disease and cancer. By consuming ACV gummies regularly, you can boost your body’s antioxidant levels and improve overall health.
Additionally, antioxidants can help improve skin health by reducing signs of aging and promoting a clear complexion. ACV gummies offer a convenient way to support your skin from the inside out, giving you that healthy glow you desire.
Furthermore, the antioxidant properties of ACV can aid in boosting your immune system. By strengthening your body’s defense mechanisms, you can reduce the risk of getting sick and recover faster when you do fall ill.
Gut Health Benefits
ACV is a probiotic-rich ingredient that can help improve gut health by promoting the growth of beneficial bacteria in the digestive system. A healthy gut is essential for overall well-being, as it plays a vital role in digestion, nutrient absorption, and immune function.
ACV gummies can help balance the gut microbiome, leading to better digestion, reduced bloating, and improved nutrient absorption. By supporting your gut health with ACV gummies, you can experience better overall health and increased energy levels.
Moreover, a healthy gut can contribute to weight loss by optimizing digestion and metabolism. When your gut is functioning properly, it can efficiently break down food and convert it into energy, preventing weight gain and promoting weight loss.
Blood Sugar Regulation
ACV has been shown to have a positive impact on blood sugar levels, making it a valuable supplement for individuals with diabetes or insulin resistance. By consuming ACV gummies regularly, you can help regulate blood sugar spikes and improve insulin sensitivity.
Additionally, ACV can aid in weight management by reducing cravings and promoting a feeling of fullness. By stabilizing blood sugar levels, ACV gummies can help prevent overeating and support a healthy weight.
Furthermore, ACV gummies can help lower cholesterol levels and reduce the risk of heart disease. By improving blood sugar regulation, ACV contributes to better heart health and overall well-being.
Detoxification Benefits
ACV is known for its detoxifying properties, as it can help cleanse the body of toxins and waste products. By consuming ACV gummies regularly, you can support your body’s natural detoxification processes and promote a healthy liver function.
Detoxification is essential for overall health, as it helps eliminate harmful substances from the body and prevents toxin buildup. ACV gummies offer a convenient way to support detoxification and maintain optimal health.
Moreover, detoxification can aid in weight loss by promoting fat metabolism and reducing water retention. By supporting your body’s detoxification pathways with ACV gummies, you can enhance your weight loss efforts and achieve your fitness goals.
Improved Digestion
ACV gummies can help improve digestion by stimulating stomach acid production and enhancing nutrient absorption. Proper digestion is crucial for overall health, as it enables the body to break down food and extract essential nutrients for energy and vitality.
By consuming ACV gummies before meals, you can support digestion and prevent digestive issues such as bloating, gas, and indigestion. The acidic nature of ACV can help optimize digestion and promote gut health.
Furthermore, improved digestion can lead to better weight management by enhancing nutrient absorption and reducing inflammation. By supporting your digestive system with ACV gummies, you can improve your metabolism and facilitate weight loss.
Summary and FAQ
In summary, ACV gummies offer a convenient and delicious way to enjoy the numerous health benefits of apple cider vinegar. From antioxidant properties to gut health benefits, ACV gummies can support overall well-being and promote weight loss. By incorporating ACV gummies into your daily routine, you can experience improved digestion, better gut health, and enhanced detoxification.
Here are some frequently asked questions about ACV gummies:
Q: Are ACV gummies as effective as liquid apple cider vinegar?
A: While ACV gummies may offer a more palatable option for consuming apple cider vinegar, the effectiveness may vary depending on the brand and formulation. It’s essential to choose high-quality ACV gummies with a sufficient amount of apple cider vinegar to experience the full benefits.
Q: Can ACV gummies help with weight loss?
A: ACV gummies can support weight loss by improving digestion, balancing blood sugar levels, and promoting detoxification. When combined with a healthy diet and regular exercise, ACV gummies can aid in weight management and enhance weight loss efforts.
Q: Are there any side effects of consuming ACV gummies?
A: While ACV gummies are generally safe for consumption, some individuals may experience digestive issues such as bloating or gas. It’s essential to follow the recommended dosage and consult with a healthcare provider if you have any concerns or underlying health conditions.
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Are GLP-1 agonists the game-changer in preventing and managing prediabetes and type 2 diabetes? In this video, we'll dive into the world of glucagon-like peptide-1 receptor agonists, exploring their benefits, mechanism of action, and potential side effects. From improving insulin sensitivity to reducing body weight, we'll examine the evidence behind GLP-1 agonists and their role in saving you from the grip of prediabetes and type 2 diabetes. Get ready to take control of your health and learn how these powerful medications can be a vital tool in your diabetes prevention and management arsenal. #diabetesmanagement #prediabetes #heartdiseaseprevention
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Shark Tank, the hit TV show where entrepreneurs pitch their business ideas to a panel of investors, has featured a wide array of products over the years. One product that caught the attention of viewers was a fat-melting product that promised to help people shed unwanted pounds with ease. The product, aptly named “The Heat Is On for Weight Loss,” claimed to use innovative technology to target fat cells and melt them away.
Revolutionary Weight Loss Solution
When the creators of The Heat Is On for Weight Loss stepped into the Shark Tank, they were met with skepticism from the investors. However, as they demonstrated the product’s effectiveness and the science behind it, the sharks were impressed. The product was designed to be used in conjunction with a healthy diet and exercise regimen, making it a comprehensive weight loss solution.
The Heat Is On for Weight Loss harnesses the power of heat to target stubborn fat cells that are resistant to traditional weight loss methods. By using a specialized heat technology, the product stimulates metabolism and helps the body burn fat more efficiently. This innovative approach to weight loss garnered the attention of the sharks, who saw the potential for widespread success.
Unlike other weight loss products on the market, The Heat Is On for Weight Loss is non-invasive and does not require surgery or harsh chemicals. This makes it a safe and effective option for those looking to slim down and improve their health. The creators of the product emphasized the importance of maintaining a healthy lifestyle while using the product, ensuring that users would see long-lasting results.
Successful Pitch and Investment
After a heated discussion among the sharks, a deal was struck with one of the investors who saw the value in The Heat Is On for Weight Loss. The creators walked away with a significant investment that would help them bring the product to market and reach a wider audience. The success of their pitch was a testament to the effectiveness of the product and the potential for growth in the weight loss industry.
The Heat Is On for Weight Loss quickly gained popularity among consumers who were eager to try a new approach to weight loss. With positive reviews and testimonials pouring in, the product garnered attention from health experts and celebrities alike. Its innovative technology and proven results set it apart from other weight loss products, making it a top choice for those looking to shed pounds and improve their overall health.
As news of The Heat Is On for Weight Loss spread, demand for the product skyrocketed. The creators expanded their distribution channels and launched an aggressive marketing campaign to reach a wider audience. With the backing of the sharks and a loyal customer base, the product became a household name in the weight loss industry.
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Transforming Lives and Inspiring Change
One of the most powerful aspects of The Heat Is On for Weight Loss is its ability to transform lives and inspire change. Users of the product reported not only significant weight loss but also improvements in their overall health and well-being. By providing a safe and effective weight loss solution, the product helped countless individuals achieve their goals and live healthier, happier lives.
Through their innovative approach to weight loss, the creators of The Heat Is On for Weight Loss sparked a revolution in the industry. They proved that it was possible to achieve lasting results without resorting to extreme measures or fad diets. The product’s success inspired others to take charge of their health and pursue their weight loss goals with confidence.
With its unique technology and proven results, The Heat Is On for Weight Loss continues to be a game-changer in the weight loss industry. It has set a new standard for effective and sustainable weight loss solutions, helping users achieve their desired results and maintain a healthy lifestyle. The product’s impact goes beyond just shedding pounds—it empowers individuals to take control of their health and lead happier, more fulfilling lives.
Investing in Your Health
As you consider your weight loss journey, it’s important to remember that there is no one-size-fits-all solution. The key to success lies in finding a weight loss product that aligns with your goals and values. The Heat Is On for Weight Loss offers a safe, effective, and innovative approach to weight loss that has transformed the lives of countless individuals. By investing in your health and well-being, you can take charge of your future and achieve the results you’ve always dreamed of.
Don’t let stubborn fat cells stand in the way of your goals—take action today and discover the power of The Heat Is On for Weight Loss. With its groundbreaking technology and proven track record, this product is a game-changer in the weight loss industry. Join the ranks of satisfied customers who have experienced real results and transformed their lives with The Heat Is On for Weight Loss. Your weight loss journey starts now—make the investment in your health and see the difference it can make.
Take the first step toward a healthier, happier you with The Heat Is On for Weight Loss. Say goodbye to unwanted pounds and hello to a new, confident you. Order your supply today and experience the transformative power of The Heat Is On for Weight Loss. Your best self is waiting—don’t wait any longer to make a change.
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