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Struggling to find Ozempic or Mounjaro? You're not alone! In this video, we explore the skyrocketing demand and supply shortages of weight loss medications like Ozempic (Semaglutide) and Mounjaro (Tirzepatide). Discover the frustrations of patients and doctors, the impact of insurance barriers, compounded medication bans, and cultural perceptions shaping accessibility in the US and Australia. Whether you're a healthcare professional or someone searching for solutions, this episode breaks it down with evidence-based insights. Stay informed on these hot health topics and join the conversation about the future of obesity treatments. Ozempic = Semaglutide (the US and Australia) Wegovy (= Semaglutide, Australia only, weight loss) Mounjaro = Tirzepatide (the US and Australia Zepbound (= Tirzepatide, the US only, weight loss, sleep apnoea) REFERENCES Weight regain after discontinuing medications like Ozempic and Mounjaro 1. “Discontinuation of semaglutide and weight regain”Diabetes, Obesity and Metabolism (2022) 2. “Here’s How Much Weight People Regain After Stopping Mounjaro or Zepbound” Author: Sarah Fielding; Healthline (2023) 3. “Effect of Continued vs Discontinued Semaglutide Treatment on Weight Maintenance” Authors: Rubino D, Greenway FL, Khalid U, et al.;The Lancet Diabetes & Endocrinology (2021) The Frustration and Struggles of Physicians 1.“Insurance Coverage of Obesity Medications.” JAMA. 2022 2.“Obesity Medications and Access to Care: Challenges in Insurance Coverage.” Obesity Medicine News, 2023. 3. “Barriers to Accessing FDA-Approved Obesity Medications.” American Journal of Managed Care. 2023 4. “Insurance Barriers and Access to Weight Loss Drugs.” Endocrine Reviews, 2023. 5. “Economic Impact of Insurance Denials on Obesity Treatment Access.” Health Affairs. 2023 6. Australian Physicians’ Concerns: RACGP; Simple Online Doctor Australia Accessibility and Supply: TGA.gov.au; RACGP; (Source: Chemist2U) Compounded Medications Ban: RACGP; Diabetes Victoria; Private Health Insurance Landscape; Insurance Business Australia; Bupa FAQs Approval and Prescribing Practices: (Source: TGA, Source: RACGP). PBS Subsidies and Costs: Health.gov.au; MyDr.com.au United States Approval and Prescribing Practices: (Source: FDA, Source: Lilly Pricing Info). Accessibility and Supply: (Source: FDA) Cultural Perception and Media Coverage Australia:(Source: The Australian) United States:(Source: Bloomberg) #Ozempic, #Mounjaro, #WeightLossMedication, #HealthPodcast, #Semaglutide, #Tirzepatide, #ObesityTreatment, #InsuranceBarriers, #Wegovy, #Zepbound, #HealthTips, #WeightLossJourney, #HealthCareAccess, #AustraliaHealth, #USHealth

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Click Here to Subscribe: http://Bit.ly/ThomasVid Check out Perfect Keto's Collagen and use my $5 gift card AND get free shipping: http://perfectketo.com/td5offcollagen My Website: http://ThomasDeLauer.com 8 Side Effects of the Ketogenic Diet + How to Reverse Them - Thomas DeLauer Skin Health - Skin dries out with dehydration (Fix with Collagen) A study published in the International Journal of Molecular Sciences looked at the effects of collagen peptides on skin epidermal moisturization after ultraviolet B irradiation-induced skin dehydration Hairless mice were orally administered CP at two doses (500 and 1000 mg/kg) for nine weeks, and the dorsal skin was exposed to UVB. Oral administration of CP increased skin hydration and decreased wrinkle formation compared to the UVB-irradiated group. Treatment of CP increased the mRNA and protein expression of hyaluronic acid synthases (HAS-1 and -2) concomitant with an increased hyaluronic acid production in skin tissue The expression of hyaluronidase (HYAL-1 and 2) mRNA was downregulated in the CP-treated group. In addition, the protein expression of skin-hydrating factors, filaggrin and involucrin, was upregulated via oral administration of CP In summary, these results show that oral administration of CP increases hyaluronic acid levels, which decreases during UVB photoaging https://www.sciencedirect.com/science/article/pii/S1047847717301302 https://pubs.acs.org/doi/10.1021/jp2025768 https://www.ncbi.nlm.nih.gov/pubmed/30423867 Fatigue - Mag ATP Gluconeogenesis increases on keto, demanding more ATP ATP (adenosine triphosphate), the main source of energy in cells, must be bound to a magnesium ion in order to be biologically active - what is called ATP is often actually Mg-ATP Loss of Anaerobic Power The bulk of ATP for anaerobic exercise comes from glycolysis - the glycolytic process requires that muscle cells breakdown glycogen to glucose via the glycogen phosphorylase pathway One possible mechanism for reduced anaerobic capacity may be attributed to the LCD-induced keto-acidosis, which was reflected in the present study by reduction of blood pH. It is well established that anaerobic glycolysis is limited by acidosis via inhibition of the rate limiting enzyme, phosphofructokinase PFK-1 catalyzes the important "committed" step of glycolysis, the conversion of fructose 6-phosphate and ATP to fructose 1,6-bisphosphate and ADP https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520927/ Headaches Dehydration When the body is dehydrated, the brain can temporarily contract or shrink from fluid loss - this mechanism causes the brain to pull away from the skull, causing pain and resulting in a dehydration headache. Once rehydrated, the brain plumps up and returns to its normal state, relieving the headache. Also believed that blood vessels in the head may actually narrow in an attempt to regulate body fluid levels - this would make it harder for oxygen and blood to get to the brain, a headache results https://www.ncbi.nlm.nih.gov/pubmed/20336685 Believed that a keto diet would attenuate migraines due to ketones being able to counteract the neuroinflammation involved in migraines https://www.ncbi.nlm.nih.gov/pubmed/28527061 Per The Journal of Headache and Pain: Migraineurs were found and enrolled in a dietician clinical setting. All clinical data were recorded before the diet initiation and, blind to neurologist, subjects were divided in two subgroups: KD and SD followers. After a one month period of diet, patients were re-evaluated for comparisons. Headache frequency and drug consumption was reduced during the observation period, but only in KD group. Responder rates in KD group (52 subjects) were higher than 90% in terms of attack frequency and drug consumption in the month of observation, while SD group (56 subjects) has no effect. Responder rate: 90% of those in the KD group saw reductions in migraines https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620251/ Muscle Stiffness (Omega 6 Related) Constipation Dehydration & electrolyte deficiency is also a cause of constipation and is a problem people on the keto diet face. Our stools are largely composed of water - 75% of the feces is composed of water, while only 25% is attributed to solids Keto Breath The liver breaks down acetone - the smell can vary, but it usually has a fruity (like the smell of rotten apples) smell – usually likened to the smell of nail varnish remover (acetone is a chemical in nail polish remover) Keto Rash - Neutrophilic Infiltration Ketone bodies are thought to accumulate around blood vessels, leading to a predominantly neutrophilic inflammation The ketones subsequently enter the cells, leading to alterations in intracytoplasmic cellular processes [note: “intracytoplasmic” = inside the cytoplasm, which is part of the inside of a cell] https://www.ncbi.nlm.nih.gov/pubmed/12652193

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When it comes to managing weight loss in individuals with type 2 diabetes, two commonly prescribed medications are Metformin and Semaglutide. Both medications have been shown to be effective in aiding weight loss, but they work in different ways. Metformin is a first-line medication for type 2 diabetes that helps to lower blood sugar levels by decreasing the amount of glucose produced by the liver. On the other hand, Semaglutide is a newer medication that belongs to a class of drugs called GLP-1 receptor agonists, which work by increasing insulin production and decreasing appetite.

Metformin: The Gold Standard

Metformin has been the go-to medication for managing type 2 diabetes for many years. It is affordable, has been extensively studied, and has a long track record of safety. In addition to its primary role in lowering blood sugar levels, Metformin has also been shown to aid in weight loss in some individuals. This weight loss is typically modest, ranging from 1-2 kg on average, but can be significant for those looking to shed a few extra pounds.

One of the reasons Metformin may help with weight loss is its effect on insulin sensitivity. By improving the body’s response to insulin, Metformin can help to reduce cravings and promote a feeling of fullness, making it easier for individuals to adhere to a healthy diet and lose weight. Additionally, Metformin has been shown to have a modest effect on metabolism, helping the body to burn calories more efficiently.

While Metformin is generally well-tolerated, some individuals may experience gastrointestinal side effects such as nausea, diarrhea, or stomach discomfort. These side effects typically subside over time as the body adjusts to the medication. In rare cases, more serious side effects such as lactic acidosis can occur, so it is important for individuals taking Metformin to be monitored by their healthcare provider.

Semaglutide: The New Kid on the Block

Semaglutide is a newer medication that has shown promising results in aiding weight loss in individuals with type 2 diabetes. In clinical trials, Semaglutide has been shown to help individuals lose significantly more weight than Metformin, with some patients experiencing weight loss of 10% or more of their body weight. This weight loss is thought to be due to Semaglutide’s effect on appetite regulation, as it helps to reduce cravings and promote a feeling of fullness.

In addition to its weight loss benefits, Semaglutide has also been shown to have other positive effects on health, such as improving blood sugar control, reducing inflammation, and lowering blood pressure. This makes Semaglutide an attractive option for individuals with type 2 diabetes who struggle with weight management and are looking for additional health benefits beyond just lowering their blood sugar levels.

While Semaglutide is generally well-tolerated, some individuals may experience gastrointestinal side effects similar to those seen with Metformin. These side effects typically improve over time and can be managed by adjusting the dose of the medication. It is important for individuals taking Semaglutide to be monitored by their healthcare provider to ensure that they are responding well to the medication and to address any potential side effects.

Comparing Efficacy: Metformin vs Semaglutide

When comparing the efficacy of Metformin and Semaglutide for weight loss in individuals with type 2 diabetes, it is clear that Semaglutide is the more effective option. Semaglutide has been shown to produce significantly greater weight loss compared to Metformin, with some individuals experiencing weight loss of 10% or more of their body weight. This makes Semaglutide a compelling option for individuals who are struggling to lose weight with other medications or lifestyle changes.

However, it is important to note that both Metformin and Semaglutide can be effective in aiding weight loss, and the choice between the two medications will ultimately depend on individual factors such as tolerance, cost, and personal preferences. Some individuals may respond better to Metformin due to its long track record of safety and affordability, while others may prefer the more significant weight loss seen with Semaglutide.

In conclusion, both Metformin and Semaglutide are viable options for individuals with type 2 diabetes who are looking to lose weight. While Semaglutide has been shown to produce greater weight loss compared to Metformin, both medications can be effective in aiding weight loss when used as part of a comprehensive treatment plan. It is important for individuals to work closely with their healthcare provider to determine the best medication for their individual needs and to monitor their progress over time.

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Immer mehr Menschen suchen nach effektiven Methoden, um Gewicht zu verlieren und ihren Körper in Form zu bringen. Eine beliebte Option, die in letzter Zeit viel Aufmerksamkeit erhalten hat, ist die Verwendung von Creatin als Nahrungsergänzungsmittel zur Gewichtsreduktion. Aber kann Creatin wirklich bei der Gewichtsabnahme helfen? In diesem Artikel werden wir uns genauer damit befassen, wie Creatin funktioniert und ob es tatsächlich ein nützliches Werkzeug zur Unterstützung des Abnehmens sein kann.

Wie funktioniert Creatin?

Creatin ist eine natürliche Substanz, die in unserem Körper vorkommt und hauptsächlich in Muskeln gespeichert ist. Es spielt eine entscheidende Rolle bei der Energieversorgung der Muskeln während intensiver körperlicher Aktivitäten wie Krafttraining oder Sprinten. Durch die Einnahme von Creatin als Nahrungsergänzungsmittel kann der Creatinspiegel im Muskel erhöht werden, was die Leistungsfähigkeit steigern und die Erholungszeit verkürzen kann.

Darüber hinaus hat Creatin auch eine stark wasserbindende Wirkung, die zu einer kurzfristigen Gewichtszunahme führen kann. Dies geschieht, weil Creatin das Wasser in den Muskeln speichert, was zu einer sichtbaren Zunahme des Muskelvolumens führen kann. Dieser Effekt kann jedoch dazu führen, dass sich die Zahl auf der Waage vorübergehend erhöht, was viele Menschen fälschlicherweise als Fettzunahme interpretieren.

Es ist wichtig zu beachten, dass Creatin kein direktes „Fettverbrennungs“-Nahrungsergänzungsmittel ist und nicht dazu gedacht ist, Fettzellen zu zerstören oder den Stoffwechsel zu beschleunigen. Stattdessen wirkt Creatin auf eine andere Weise, die zur Verbesserung der Trainingsleistung und zur Förderung von Muskelaufbau beitragen kann.

Die Rolle von Creatin bei der Gewichtsreduktion

Obwohl Creatin kein direktes Mittel zur Gewichtsabnahme ist, kann es dennoch eine unterstützende Rolle spielen, wenn es um das Abnehmen geht. Indem es die Trainingsleistung verbessert und die Erholungszeit verkürzt, kann Creatin dazu beitragen, dass Sie intensiver und effektiver trainieren, was wiederum zu einem erhöhten Kalorienverbrauch führen kann.

Ein weiterer potenzieller Vorteil von Creatin bei der Gewichtsreduktion ist seine wasserbindende Eigenschaft. Durch die Zunahme von Wasser in den Muskeln kann Creatin dazu beitragen, dass Ihr Körper straffer und muskulöser aussieht, was Ihnen ein zusätzliches Motivationsschub geben kann, um Ihr Trainingsprogramm fortzusetzen.

Es ist jedoch wichtig zu beachten, dass die Wirkung von Creatin bei der Gewichtsreduktion von Person zu Person variieren kann. Nicht jeder wird die gleichen Vorteile erleben, und es gibt keine Garantie dafür, dass Creatin allein ausreicht, um signifikante Gewichtsabnahme zu erreichen. Es sollte daher als Teil eines umfassenden Gewichtsreduktionsprogramms angesehen werden.

Die richtige Dosierung und Anwendung von Creatin

Wenn Sie sich dazu entscheiden, Creatin als Nahrungsergänzungsmittel zur Unterstützung Ihrer Gewichtsreduktion zu verwenden, ist es wichtig, die richtige Dosierung und Anwendung zu beachten. Die empfohlene Tagesdosis für die ersten Tage der „Ladephase“ beträgt in der Regel 20 Gramm Creatin, die auf mehrere Dosen aufgeteilt werden sollten, um die Magenverträglichkeit zu verbessern.

Nach der Ladephase wird eine Erhaltungsdosis von 3-5 Gramm Creatin pro Tag empfohlen, die am besten nach dem Training eingenommen wird, um die Muskelaufnahme zu maximieren. Es ist auch wichtig, viel Wasser zu trinken, wenn Sie Creatin verwenden, da es zu einer Dehydratation führen kann, wenn nicht genügend Flüssigkeit konsumiert wird.

Es wird empfohlen, Creatin für 8-12 Wochen zu verwenden, gefolgt von einer Pause von mindestens 4 Wochen, um eine mögliche Abhängigkeit zu vermeiden und sicherzustellen, dass Ihr Körper nicht negativ beeinflusst wird. Wenn Sie sich nicht sicher sind, wie Sie Creatin am besten verwenden sollen, konsultieren Sie am besten einen Arzt oder Ernährungsberater.

Die Bedeutung einer ausgewogenen Ernährung und regelmäßigen Bewegung

Es ist wichtig zu betonen, dass Creatin allein nicht ausreicht, um Gewicht zu verlieren und einen gesunden, fitten Körper zu erreichen. Eine ausgewogene Ernährung, die reich an Obst, Gemüse, magerem Eiweiß und Vollkornprodukten ist, sowie regelmäßige körperliche Aktivität sind unerlässlich, um langfristige Erfolge bei der Gewichtsreduktion zu erzielen.

Daher sollte Creatin nur als Ergänzung zu einer gesunden Lebensweise betrachtet werden und nicht als Ersatz für eine ausgewogene Ernährung und Sport. Wenn Sie sich unsicher sind, wie Sie Ihre Gewichtsabnahmeziele am besten erreichen können, sprechen Sie mit einem Fachmann, der Ihnen dabei helfen kann, einen maßgeschneiderten Plan zu erstellen, der auf Ihre individuellen Bedürfnisse zugeschnitten ist.

Insgesamt kann Creatin eine nützliche Ergänzung sein, um Ihre Trainingsleistung zu verbessern und Ihren Körperbau zu optimieren, aber es ist wichtig, realistische Erwartungen zu haben und es als Teil eines umfassenden Ansatzes zur Gewichtsreduktion zu betrachten. Mit der richtigen Dosierung, Anwendung und Unterstützung können Sie möglicherweise von den potenziellen Vorteilen von Creatin profitieren und Ihren Zielen näherkommen.