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Is LDL cholesterol the best way to measure and predict heart disease? New research suggests no! Dave Feldman is an engineer turned citizen scientist who has devoted his life to understanding a phenomenon that some individuals around the world are experiencing: a robust increase in LDL cholesterol while on a ketogenic diet. Dave’s past research has identified a unique phenotype dubbed Lean Mass Hyper-Responders (LMHRs). LMHRs respond to ketogenic therapy with a metabolic profile that includes elevated LDL-C and ApoB levels with otherwise healthy metabolic markers, including low triglycerides, high HDL, low blood pressure, low insulin resistance, and low BMI. In Dave’s most recent publication, what most doctors would consider dangerously high LDL levels in LMHRs did not correlate with an increased risk of heart disease. In this video, Dr. Bret Scher sits down with Dave Feldman to discuss this groundbreaking study and its implications for ketogenic therapy and cardiology. *Key Takeaways:* - LMHRs on a long-term ketogenic diet who show elevated LDL can show robust metabolic health - LDL-C and ApoB were not linked to plaque progression in LMHRs - Existing plaque did predict future plaque accumulation in LMHRs - Individualized approaches to cardiovascular risk assessment are crucial to serve this group better. 🎬 These exciting new findings are featured in Dave Feldman and Jen Isenhart’s upcoming documentary, *The Cholesterol Code,* the story of how one engineer’s health experiment sparks a global investigation, exposing myths about cholesterol and reshaping our understanding of heart health. Real stories of healing from disease with ketogenic diets provide a blueprint for using food as powerful medicine. Visit [cholesterolcodemovie.com](https://cholesterolcodemovie.com/) to learn more about the film and to be the first to hear about private screenings and the general release in the fall. *Expert Featured:* Dave Feldman CEO, Citizen Science Foundation https://x.com/realDaveFeldman Cholesterol Code website: https://cholesterolcode.com/ *Resources Mentioned:* Coronary Artery Plaque Progression in Asymptomatic Lean Mass Hyper-Responders: A Case Series - https://www.jacc.org/doi/10.1016/j.jacadv.2025.101686 *CMEs Mentioned:* _Managing Major Mental Illness with Dietary Change: The New Science of Hope_ - https://www.mycme.com/courses/managing-major-mental-illness-with-dietary-change-9616 _Brain Energy: The Metabolic Theory of Mental Illness_ - https://www.mycme.com/courses/brain-energy-the-metabolic-theory-of-mental-illness-9615 Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry. Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/ *About us:* Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them. Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications. *Timestamps:* 0:00 - Introduction to Lean Mass Hyper Responders and researcher Dave Feldman. 3:10 - What is the background and setup of Dave’s new Lean Mass Hyper Responder (LMHR) trial? What did the participants’ baseline data look like? 8:00 - What did the 1 year follow up scans show for the participants? Did their elevated LDL & ApoB lead to an increase in plaque buildup? What is the difference between LDL & ApoB? 21:42 - Did the group see an increase in plaque volume and was it rapid? Did anyone see a decrease? What does predict a future increase in plaque if not LDL or ApoB? 26:48 - What causes arterial plaque and what doesn’t cause it? 29:45 - Will Dave Feldman’s study help clinicians and patients accept or continue ketogenic therapy when LDL may be high? 33:09 - What are the limitations to the study and the interpretations to the study? 39:10 - What does Dave Feldman hope a cardiovascular researcher would take away from this study? How does Dave feel about potential pushback from the medical community? 43:45 - Where can people hear more from Dave Feldman and follow his work?

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As one of the most popular reality TV shows, Shark Tank has introduced viewers to a wide range of innovative and exciting products over the years. With the rise of the keto diet trend, many entrepreneurs have taken the opportunity to pitch their keto-friendly products to the sharks in hopes of securing a deal. These products range from low-carb snacks to ketogenic meal kits, each offering a unique take on how to make keto living easier and more enjoyable.

Notable Keto Products on Shark Tank

One of the most memorable keto product pitches on Shark Tank was from the creators of Nui Cookies. These low-carb, high-fat cookies were positioned as a guilt-free indulgence for those following a ketogenic diet. The founders emphasized the natural ingredients and lack of artificial sweeteners, which resonated with the sharks and led to a successful deal. Nui Cookies have since become a staple in the keto community, offering a delicious treat for those looking to satisfy their sweet tooth without derailing their diet.

Another standout keto product pitch came from the founders of Super Coffee, a line of ready-to-drink coffee beverages infused with MCT oil and protein. The entrepreneurs highlighted the convenience and health benefits of their products, which appealed to consumers looking for a quick and easy way to boost their energy levels while sticking to their keto goals. The sharks were impressed by the company’s rapid growth and market potential, ultimately leading to a deal that has helped Super Coffee become a household name in the keto community.

One of the more unique keto product pitches on Shark Tank was from the creators of F-fat Fudge, a high-fat, low-carb fudge designed for those following a ketogenic diet. The founders emphasized the superior taste and texture of their product compared to traditional fudge, as well as the health benefits of consuming healthy fats while in ketosis. Despite some skepticism from the sharks, the entrepreneurs were able to secure a deal that has allowed F-fat Fudge to expand its product line and reach a wider audience of keto enthusiasts.

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What Sets These Keto Product Pitches Apart

What sets these keto product pitches apart from other pitches on Shark Tank is their focus on meeting the specific needs of the keto community. With more people adopting a ketogenic lifestyle for its health benefits and weight loss potential, there is a growing demand for high-quality, convenient keto-friendly products. The entrepreneurs behind Nui Cookies, Super Coffee, and F-fat Fudge recognized this demand and tailored their products to not only appeal to consumers but also to address common challenges faced by those following a keto diet.

In addition to offering keto-friendly alternatives to traditional snacks and beverages, these products have also helped to educate consumers about the benefits of a ketogenic diet. By highlighting the science behind ketosis and the importance of consuming healthy fats, the founders of Nui Cookies, Super Coffee, and F-fat Fudge have helped to demystify the keto lifestyle and make it more accessible to a wider audience. This educational component sets these product pitches apart from other pitches on Shark Tank and has contributed to their success in the marketplace.

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