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Download "Solution Pharmacy" Mobile App to Get All Uploaded Notes, Model Question Papers, Answer Papers, Online Test and other GPAT Materials - https://play.google.com/store/apps/details?id=co.bolton.nqilv Disclaimer:- This video is for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have watched on this channel. Vildagliptin (LAF237) is an orally active antihyperglycemic agent that selectively inhibits the dipeptidyl peptidase-4 (DPP-4) enzyme. It is used to manage type II diabetes mellitus, where GLP-1 secretion and insulinotropic effects are impaired, By inhibiting DPP-4, vildagliptin prevents the degradation of glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which are incretin hormones that promote insulin secretion and regulate blood glucose levels. Elevated levels of GLP-1 and GIP consequently results in improved glycemic control.6 In clinical trials, vildagliptin has a relatively low risk of hypoglycemia. Vildagliptin is indicated in the treatment of type II diabetes mellitus in adults. As monotherapy, vildagliptin is indicated in adults inadequately controlled by diet and exercise alone and for whom metformin is inappropriate due to contraindications or intolerance. It is also indicated as dual therapy in combination with metformin, a sulphonylurea, or a thiazolidinedione in adults patients with insufficient glycemic control despite maximal tolerated dose of monotherapy. Vildagliptin is indicated in the treatment of type II diabetes mellitus in adults. As monotherapy, vildagliptin is indicated in adults inadequately controlled by diet and exercise alone and for whom metformin is inappropriate due to contraindications or intolerance.6 It is also indicated as dual therapy in combination with metformin, a sulphonylurea, or a thiazolidinedione in adults patients with insufficient glycemic control despite maximal tolerated dose of monotherapy. Vildagliptin is also marketed in a combination product with metformin for the treatment of adults with type II diabetes mellitus who inadequately respond to either monotherapy of vildagliptin or metformin. This fixed-dose formulation can be used in combination with a sulphonylurea or insulin (i.e., triple therapy) as an adjunct to diet and exercise in adults who do not achieve adequate glycemic control with monotherapy or dual therapy. Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) are incretin hormones that regulate blood glucose levels and maintain glucose homeostasis. It is estimated that the activity of GLP-1 and GIP contribute more than 70% to the insulin response to an oral glucose challenge. They stimulate insulin secretion in a glucose-dependent manner via G-protein-coupled GIP and GLP-1 receptor signalling. In addition to their effects on insulin secretion, GLP-1 is also involved in promoting islet neogenesis and differentiation, as well as attenuating pancreatic beta-cell apoptosis. Incretin hormones also exert extra-pancreatic effects, such as lipogenesis and myocardial function Get in touch with the solution Pharmacy and Pharmacy Dictionary by just clicking the following links- Mobile App - https://play.google.com/store/apps/details?id=co.bolton.nqilv Facebook Group- https://www.facebook.com/groups/solutionpharamcy The main channel for a detailed Syllabus (Solution- Pharmacy) - https://www.youtube.com/c/SOLUTIONpushpendra E-Mail for official and other work - [email protected] #Pharmacydictionarybypushpendrapatel #Pharmacologyclass
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Obesity is a growing epidemic in the world, affecting millions of people and leading to various health complications. While diet and exercise are the primary methods for weight loss, some individuals may require additional help in their weight loss journey. Semaglutide is a medication that has gained attention for its potential in aiding weight loss in non-diabetic individuals. Understanding how Semaglutide works for weight loss in non-diabetics is crucial for those looking for effective weight loss solutions.
How Semaglutide Works
Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that works by mimicking the effects of a hormone produced in the intestines. GLP-1 is released after meals and helps regulate blood sugar levels by increasing insulin secretion and decreasing glucagon production. In addition to its effects on blood sugar, GLP-1 also helps regulate appetite and food intake. By activating the GLP-1 receptor, Semaglutide can increase feelings of fullness, reduce hunger, and ultimately lead to weight loss.
When Semaglutide is administered, it binds to the GLP-1 receptor in the gut and brain, signaling the body to produce more insulin and reduce the production of glucagon. This helps stabilize blood sugar levels and reduce cravings for high-calorie foods. Additionally, Semaglutide slows down the emptying of the stomach, leading to a longer feeling of fullness and decreased food intake.
Studies have shown that Semaglutide can lead to significant weight loss in non-diabetic individuals. In a clinical trial involving over 2,000 participants, those who were given Semaglutide lost an average of 15% of their body weight, compared to only 2.4% in the placebo group. This significant difference highlights the effectiveness of Semaglutide in promoting weight loss in individuals struggling with obesity.
Potential Side Effects
Like any medication, Semaglutide can have side effects that individuals should be aware of before starting treatment. Common side effects of Semaglutide include nausea, vomiting, diarrhea, and constipation. These gastrointestinal symptoms usually subside after the initial weeks of treatment but can be bothersome for some individuals. It is important to discuss any concerns about side effects with a healthcare provider before starting Semaglutide.
In rare cases, Semaglutide can also cause more severe side effects such as pancreatitis or kidney problems. Individuals with a history of pancreatitis or kidney disease should be cautious when considering Semaglutide for weight loss. Additionally, Semaglutide is not recommended for pregnant or breastfeeding women due to potential risks to the fetus or infant. It is crucial to consult with a healthcare provider to determine if Semaglutide is a safe and appropriate option for weight loss.
Despite the potential side effects of Semaglutide, many individuals find the benefits of weight loss outweigh the risks. Working closely with a healthcare provider can help monitor for any potential side effects and adjust the dosage as needed to minimize discomfort. It is essential to be aware of the possible side effects of Semaglutide while also focusing on the potential positive impact it can have on weight loss goals.
Long-Term Impact
Weight loss achieved with Semaglutide can have a long-lasting impact on overall health and well-being. In addition to improving physical health by reducing the risk of obesity-related diseases such as diabetes, heart disease, and stroke, weight loss can also improve mental health and quality of life. Individuals who lose weight with Semaglutide often report increased energy levels, improved self-esteem, and a better overall sense of well-being.
Studies have shown that maintaining weight loss over the long term can be challenging, but Semaglutide may help individuals sustain their weight loss goals. By helping regulate appetite and food intake, Semaglutide can support individuals in making healthier food choices and maintaining a lower caloric intake. This can lead to long-term weight management and a reduced risk of weight regain, setting individuals up for continued success in their weight loss journey.
Understanding the long-term impact of Semaglutide on weight loss can help individuals make informed decisions about their treatment plan and set realistic expectations for their weight loss goals. By combining Semaglutide with healthy lifestyle changes such as diet and exercise, individuals can experience lasting weight loss results and improved overall health and well-being.
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Today, more and more people are adopting the ketogenic diet as a means of shedding excess weight and boosting health and vitality throughout every cell in the body. This surge of interest has given rise to a slew of supplements designed to enhance the ketogenic lifestyle from different angles. Complete Keto aims to give people just that by providing them with everything they need to excel on a keto diet. This product was featured on the nationally syndicated TV show Shark Tank.
Exploring Complete Keto from Shark Tank
Complete Keto is a keto diet supplement, and the way it claims they can support weight loss, increase energy levels, and improve mental clarity. They say that taking Complete Keto can move people into ketosis much quicker than dieting alone, and it helps them get the results that they’re aiming for while on the keto diet. Complete Keto seems to be making the rounds on TV, specifically as being endorsed by the Shark Tank investors. Many consumers were inspired to try Complete Keto for themselves.
The main ingredient in Complete Keto is beta-hydroxybutyrate (BHB), the ketone body that helps your body achieve ketosis by providing readily available energy to the body. Studies have proven that taking BHB as a supplement causes mental clarity and alertness, and users of Complete Keto report that after a brief period of using Complete Keto, they experienced a surge in energy and mental clarity.
The second main ingredient in Complete Keto is medium-chain triglycerides (MCTs), fats that are metabolised into ketones by the liver. MCTs are popular in keto supplements because they are thought to help keep the body in ketosis, maximising fat-burning while also providing a direct source of energy. People who have used Complete Keto have reported that it helps suppress their appetite and leaves them feeling full for longer.
Benefits of Complete Keto
Complete Keto is designed to help you lose weight and boost your health for a variety of reasons. It supposedly will keep you in ketosis so that your body will use more fat as fuel for achieving weight loss and remaining lean. Complete Keto improves energy and mental focus because it increases levels of ketones in the body, making users feel more alert and energetic when taking the product.
On top of that, Complete Keto could help you maintain stable blood sugar levels, control your release of insulin, and perhaps help those with certain metabolic conditions like diabetes. Once you start burning more fat and decreasing your carbohydrate intake, the supplement could help you see some improvement. However, be sure to speak to a licensed healthcare provider before starting any new supplementation regimen.
In short: I think Keto Complete produces a fairly effective supplement on the keto diet, and it definitely looks like a fine idea to give it a try! What did you think of this review? Would you like to try Keto Complete from Shark Tank? Please share your thoughts and opinions in the comments section below. Complete Keto is a great supplement for people wanting to embark on a ketogenic journey. With its unique blend of BHB and MCTs, this product helps to burn fat while boosting energy levels and promoting brain activity. Though every body reacts differently, many people have reported bit the device for health and fitness purposes.
FAQ about Complete Keto
1. How long does it take to see results with Complete Keto?
Results may vary, but some individuals report increased energy and weight loss in as little as a few short weeks with Complete Keto.
2. Are there any side effects of using Complete Keto?
Complete Keto is well tolerated but some people may experience mild gastrointestinal discomfort or minor side effects when starting the supplement. Begin with the lowest dosage and increase as needed.
3. Can I take Complete Keto if I have a medical condition?
If you have medical conditions or are taking medications, it’s always a good idea to talk to a healthcare provider before making any drastic changes to your diet, including taking a supplement like Complete Keto, to make sure it’s safe for you.
4. How should Complete Keto be taken for optimal results?
For maximum results, users can take Complete Keto as prescribed on its label while maintaining a proper diet and making sure to exercise often.
5. Where can I purchase Complete Keto?
You can order Full Keto from the official page of the website or from some other trusted seller. Just ensure that you get the product from a reputable manufacturer.
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The Keto BHB supplement gained its popularity after being featured on Shark Tank for its potential weight loss benefits. But what exactly is BHB and how does it work? In this article, we will explore the BHB phenomenon and explain how it can help you achieve your keto diet goals.
The Science Behind BHB
BHB, or beta-hydroxybutyrate, is a ketone body that is produced in the liver from fatty acids during periods of low carbohydrate intake. It serves as an alternative energy source for the brain and muscles when glucose levels are low. BHB is considered to be one of the most abundant ketone bodies in the body, making up about 78% of the total ketones in the blood.
When you are following a ketogenic diet, your body switches from using glucose as its primary source of energy to using fat for fuel. This shift in metabolism leads to the production of ketones, including BHB, which are used by the body for energy production. In essence, BHB helps the body enter a state of ketosis, where it burns fat for fuel instead of carbohydrates.
Benefits of Keto BHB
One of the key benefits of using a Keto BHB supplement is its ability to help you reach ketosis faster. By providing the body with exogenous ketones, BHB supplements can help jumpstart the ketosis process, making it easier to achieve and maintain a state of fat burning. This can be especially helpful for those who are new to the ketogenic diet or who struggle to stay in ketosis.
In addition to promoting ketosis, BHB supplements may also help reduce cravings and hunger, making it easier to stick to a low-carb diet. BHB has been shown to increase levels of the hormone ghrelin, which is responsible for signaling hunger in the brain. By supplementing with BHB, you may be able to curb your appetite and avoid overeating.
How to Incorporate Keto BHB into Your Routine
There are various ways to incorporate Keto BHB into your daily routine, depending on your preferences and lifestyle. BHB supplements are available in various forms, including powders, pills, and drinks, making it easy to find a product that suits your needs. Some people prefer to take their BHB supplement in the morning to help kickstart their day, while others may choose to take it before a workout for an added energy boost.
It is important to note that while BHB supplements can be a helpful tool for reaching ketosis and supporting weight loss, they should not be used as a substitute for a balanced diet and regular exercise. Incorporating BHB supplements into a healthy lifestyle that includes nutritious foods and physical activity can help maximize their benefits and support overall well-being.
Potential Side Effects of BHB Supplements
While BHB supplements are generally considered safe for most people, there are some potential side effects to be aware of. Some users may experience digestive issues such as bloating, diarrhea, or stomach discomfort when first starting BHB supplementation. These side effects are usually mild and temporary, and can often be minimized by starting with a lower dose and gradually increasing it over time.
Individuals with certain medical conditions, such as diabetes or kidney disease, should consult with a healthcare provider before taking BHB supplements. It is also important to follow the recommended dosage instructions provided by the manufacturer to ensure safe and effective use of BHB supplements. By being mindful of these considerations, you can enjoy the benefits of BHB supplementation while minimizing any potential risks.
Summary and FAQs
In conclusion, Keto BHB supplements can be a valuable tool for reaching ketosis, supporting weight loss, and managing cravings. By understanding the science behind BHB and how it can benefit your body, you can make an informed decision about incorporating BHB supplements into your routine. Remember to consult with a healthcare provider before starting any new supplement regimen to ensure safe and effective use.
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Here are some frequently asked questions about Keto BHB:
1. What is the recommended dosage of Keto BHB supplements?
The recommended dosage of Keto BHB supplements can vary depending on the product and individual needs. It is important to follow the dosage instructions provided by the manufacturer to ensure safe and effective use.
2. Are there any potential side effects of taking Keto BHB supplements?
While BHB supplements are generally considered safe for most people, some individuals may experience mild digestive issues when first starting supplementation. It is recommended to start with a lower dose and gradually increase it over time to minimize any potential side effects.
3. How long does it take to see results from Keto BHB supplementation?
The time it takes to see results from Keto BHB supplementation can vary depending on individual factors such as diet, exercise, and metabolism. Some people may experience benefits within a few days, while others may take longer to notice changes. Consistent use of Keto BHB supplements in conjunction with a healthy lifestyle can help maximize results over time.
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🔔 Subscribe for more evidence-based health content! Berberine has been called "nature's Ozempic" all over social media, with people claiming it can replicate the effects of GLP-1 medications. But is there any truth to these claims? 🤔 In this video, I break down what berberine actually is, how it works in your body, and what the research really shows about its effects on blood sugar, weight loss, and cholesterol. What I found: ✅ Berberine does have legitimate benefits for blood sugar control (can reduce HbA1c by ~0.73%) ✅ It can stimulate some natural GLP-1 release from intestinal cells ✅ Weight loss effects are modest (~2kg over 8-12 weeks) ✅ Extremely poor bioavailability (only 0.37-5% absorbed) ✅ Works primarily through gut microbiome changes, not systemic absorption However, comparing berberine to GLP-1 medications like Ozempic is misleading. The mechanisms are completely different, and the weight loss effects are nowhere near comparable (2kg vs 15%+ body weight loss with GLP-1 drugs). While berberine has research-backed benefits for metabolic health, it's not a replacement for prescription medications. If you need significant weight loss or diabetes management, please consult your doctor rather than relying on supplements with modest effects! 💊 The "nature's Ozempic" trend takes advantage of people looking for affordable alternatives to expensive medications, but the science doesn't support these dramatic comparisons. I hope this video helped clear things up, if you have any questions please comment below. See you in the next video and until then, keep playing the long game. 1:10 What is Berberine 3:41 How Berberine Works (AMPK & GLP-1 Effects) 6:03 What the Research Actually Shows 14:09 Final Verdict A little bit about me: My name is Kamini, I have a bachelor of pharmacy with first class honours from Curtin University. I am currently working as a registered pharmacist, while completing a master of Human Nutrition. As I go through my work and studies, I am continuously learning new things and this channel is where I pass on my learnings and knowledge to anyone that is interested so that we can all play the long game that is health, together.
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