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Today on The Human Upgrade, Dr. Anurag Singh, a renowned expert in muscle biology and aging, shares his expertise on the impact of GLP-1 agonists like Ozempic and Wegovy on weight loss, muscle health, and aging. In this episode, you'll learn about the science behind these popular drugs, their potential benefits, and the risks involved. Discover how you can maintain muscle mass while losing weight, enhance your mitochondrial function for better health, and what the future holds for medical treatments in weight management. Gain expert insights into making smart choices for your long-term health and wellness, whether you're considering these treatments or just curious about new health technologies. Sponsors: STEMREGEN | | Head to https://www.stemregen.co/dave for 20% off your first order. Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. Resources: Upgrade Labs: https://upgradelabs.com/ Vitamin DAKE | www.VitaminDAKE.com Dave Asprey’s Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Want to join The Human Upgrade Podcast Live? Join Our Upgrade Collective: https://www.ourupgradecollective.com/ Chapters: 00:00:40 - Introduction 00:02:20 - Meet Dr. Anurag Singh 00:03:35 - Basics of GLP-1 Agonists 00:07:03 - Muscle Loss Issues 00:10:41 - Common Misconceptions 00:16:14 - Metabolic Effects 00:22:10 - Fasting vs. GLP-1 Agonists 00:30:13 - Testing Mitochondrial Function 00:37:00 - Future Directions 00:43:48 - Cosmetic Concerns: 'Ozempic Face' 00:52:04 - Role of Urolithin A 01:06:02 - Predictions for Future Treatments Connect with Dave Asprey! Website: https://daveasprey.com TikTok: https://www.tiktok.com/@daveaspreyofficial Instagram: https://www.instagram.com/dave.asprey/ Facebook: https://www.facebook.com/Daveaspreyofficial/ Twitter: https://twitter.com/daveasprey YouTube: https://www.youtube.com/c/daveaspreybpr Telegram: https://t.me/aspreyofficial The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ and https://m.facebook.com/Thehumanupgrade/

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When it comes to weight loss, many individuals struggle to find an effective solution that works for them. In recent years, the pharmaceutical industry has introduced new medications that claim to aid in weight loss by targeting specific pathways in the body. Two commonly prescribed medications for weight loss are Ozempic and Semaglutide. While both medications have similarities, they also have unique differences that may make one more suitable for certain individuals.

How do Ozempic and Semaglutide work?

Ozempic and Semaglutide are both members of a class of medications known as glucagon-like peptide-1 (GLP-1) receptor agonists. These medications work by mimicking the action of GLP-1, a hormone that is naturally produced in the body in response to food intake. GLP-1 helps regulate blood sugar levels, decrease appetite, and slow down the emptying of the stomach, all of which can contribute to weight loss.

Benefits of Ozempic

Ozempic has been FDA-approved for weight management in individuals with obesity or who are overweight and have at least one weight-related comorbidity, such as high blood pressure or type 2 diabetes. Clinical trials have shown that Ozempic can lead to significant weight loss when combined with diet and exercise. Additionally, Ozempic has been shown to improve glycemic control in individuals with type 2 diabetes.

Benefits of Semaglutide

Semaglutide is another GLP-1 receptor agonist that has been approved for weight management in individuals with obesity. It is available in a higher dose formulation specifically for weight loss, known as Wegovy. Studies have demonstrated that Semaglutide can lead to even greater weight loss compared to Ozempic, making it a promising option for individuals who have struggled to lose weight with other methods.

Side effects of Ozempic and Semaglutide

Like all medications, Ozempic and Semaglutide can cause side effects in some individuals. Common side effects of both medications include nausea, vomiting, and diarrhea. These side effects are usually mild and tend to improve over time. However, more serious side effects, such as pancreatitis or thyroid cancer, are rare but possible with the use of GLP-1 receptor agonists.

Choosing between Ozempic and Semaglutide

When deciding between Ozempic and Semaglutide for weight loss, it is important to consider your individual health goals and preferences. If you have type 2 diabetes in addition to obesity, Ozempic may be a suitable option due to its dual benefits for weight management and glycemic control. On the other hand, if you are looking for a more potent weight loss medication, Semaglutide in its Wegovy formulation may be more effective for you. Ultimately, consulting with your healthcare provider can help you determine the best medication for your weight loss journey.

Summary

In conclusion, both Ozempic and Semaglutide are effective medications for weight loss that work by targeting the GLP-1 pathway in the body. While Ozempic is FDA-approved for weight management in individuals with obesity and certain comorbidities, Semaglutide, specifically in its Wegovy formulation, has shown to produce greater weight loss results. Both medications have common side effects that are usually mild and transient. When choosing between Ozempic and Semaglutide, it is essential to consider your individual health needs and preferences in consultation with your healthcare provider.

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Dr. Toyos has written the best selling book, The Toyos Dry Eye Diet. One important topic is the use of GLP 1 injections and their effects on the eye. Toyos Clinic has been studying if these medications can help with Dry Eye Disease. Dr. Toyos presented all the research currently available for GLP 1 medicine and eyes. The Good, The Bad, and The Ugly. The lecture was at the 2nd Annual Winterthur Ophthalmology Symposium in Switzerland.

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