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In this episode I chat with colleague, Jamie Mills about weight loss medications: how they work, pros and cons of using them, the stigma around taking them, if there are any natural supplements that compare, and so much more. Jamie Mills is a registered dietitian who specializes in helping women reach their goals post weight loss surgery at her private practice ⁠⁠The Sleeved Dietitian⁠⁠: https://thesleeveddietitian.com This episode is sponsored by Better Help. To save 10% on your first month of therapy, visit https://⁠⁠www.betterhelp.com/holleyfueled⁠⁠ To work with team Holley Fueled Nutrition, schedule an appointment ⁠⁠here: https://holleyfuelednutrition.com/nutrition-coaching⁠⁠.

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Hello everyone! I am so excited to share with you some new Dr. O Tips and Tricks in my new video! In this video I give you some insights as to what is happening and what you can do to change things around when you have stopped loosing weight while on Wegovy, Ozempic or Mounjaro. I also talk about the role nutrition and metabolism play in your weight-loss journey. (hint: it's a big role!), and how understanding these changes in your nutrition and metabolism can help you to succeed on your weight loss journey. I really hope you enjoy, and thank you all for watching! With Warm Regards, Dr. O INSTAGRAM: https://www.instagram.com/dromethod/ https://www.instagram.com/yourrealdro/

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Tune in to this episode of The Everyday Trader for a compelling session with Dr. Arie Blitz, a distinguished obesity medicine expert and seasoned retail trader. This episode not only delves into the forefront of obesity treatments but also navigates the investment landscape within the pharmaceutical industry. Obesity and Market Dynamics: Gain insights into the obesity epidemic and its implications on health and society. We explore comprehensive strategies for tackling obesity, integrating medical, lifestyle, and behavioral approaches. Pharmaceutical Innovations: Dr. Blitz discussed the groundbreaking GLP-1 agonist treatments, like Semaglutide and Tirzepatide, spotlighting their revolutionary roles in weight management and broader applications in diabetes care. The common brand names for these are Wegovy, Ozempic, Mounjaro, and Zepbound. FDA Shortage List and Compounding Pharmacy: Semaglutide and Tirzepatide are currently on the “FDA shortage list.” This opens the door for compounding pharmacies to legally provide the active ingredients to patients, potentially at a much lower price than available through prescription. It is not entirely understood how long this status remains and what impact this will have on LLY and NVO when they can meet supply. Investment Horizons: We pivot to the investment opportunities in the pharmaceutical sector, with a special focus on the key players, Eli Lilly (LLY) and Novo Nordisk (NVO), and their dominant positions in the market. Expanding the scope, Dr. Blitz shares insights into emerging companies like Catalent (CTLT) and Viking Therapeutics (VKTX), among others, revealing a broader spectrum of investment prospects beyond the giants. Treatment Complexities and Market Implications: Discuss the challenges and considerations of weight loss medications, including efficacy, side effects, and the economic aspects of treatment, such as cost and insurance hurdles. This segment ties the medical discussion back to investment implications, considering how these factors influence market potential and company valuations. Beyond LLY and NVO: Delve deeper into the pharmaceutical ecosystem, uncovering the roles and potentials of lesser-known entities that are shaping the future of obesity treatment and offering intriguing investment opportunities. Join us for a deep dive into the intersection of healthcare and investment, where Dr. Arie Blitz illuminates the evolving pharmaceutical landscape, from established behemoths to promising newcomers, and their roles in advancing obesity treatment. 00:00:00 Introduction and Welcome 00:01:23 Exploring Investment Opportunities in Pharma 00:04:50 Understanding Obesity: Epidemic Insights 00:14:32 GLP-1 Agonist Treatments: Revolutionizing Weight Management 00:17:39 Navigating Treatment Complexities: Efficacy and Challenges 00:30:25 FDA Shortage List and the Role of Compounding Pharmacies 00:40:20 Market Leaders NVO LYY and Others 01:02:06 Controversies Around GLP-1 01:05:50 Personal Experience Here's list of companies and medications Dr. Blitz is watching: Manufacturer Medication Underlying Name Altimmune Pemvitude Amgen AMG133 Amgen AMG786 Amgen Maridebart Cafraglutide AstraZeneca ECC5004 Biohaven Taldefgrobep BioRestorative Therapies Inc. Thermostem BOC Sciences Dapagliflozin BOC Sciences NNC0480-0389 Boehringer / Zealand Pharma Survodutide Callway Biopharmaceuticals, Ltd CBW-520 Eli Lilly Orforglipron Eli Lilly Retatrutide Eli Lilly Tirzepatide Fosun Pharma RZL-012 Fractyl Health GLP-1PGTX Fractyl Health Rejuva Hanmi Financial Corporation HM15136 Innovent Biologics Mazdutide Jiangsu Hengrui HRS9531 Merck Efinopegdutide Nano Precision Medical, Inc NPM 139 Neurobo DA-1726 Novo Nordisk Cagrisema Novo Nordisk Semaglutide Novo Nordisk Semaglutide Opko Oxyntomodulin (OPK88003) Palatin Technologies Bremelanotide Rhythm Pharmaceuticals Setmelanotide (RM493) Roche (Carmot) CT-388 Roche (Carmot) CT-868 Roche (Carmot) CT-996 Scholar Rock Apitegromab Scohia Pharma, Inc. SCO-267 Shionogi S-309309 Structure Therapeutics GSBR-1290 Sun Pharma GL0034 Terns Pharmaceuticals TERN-601 Tonix Pharmaceuticals TNX-1900 Versanis Bio / Eli Lilly Bimagrumab Veru Enobosarm Viking Therapeutics VK2735 Zealand Pharma Dapiglutide #stocks #stockmarket #options #optionstrading #optionsstrategy

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Obesity is a major health concern worldwide, affecting millions of people and increasing the risk of various chronic diseases such as diabetes, heart disease, and certain types of cancer. Despite the availability of numerous weight loss medications and treatments, many individuals struggle to achieve and maintain a healthy weight. In recent years, oral semaglutide has emerged as a promising option for weight loss in individuals with obesity. This article aims to assess the effectiveness of oral semaglutide for weight loss, exploring its mechanism of action, potential benefits, and considerations for use.

Mechanism of Action

Oral semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that helps regulate blood sugar levels and increase insulin production in response to meals. This medication works by mimicking the effects of incretin hormones produced in the gut, which stimulate insulin secretion and reduce the production of glucagon, a hormone that raises blood sugar levels. By targeting the GLP-1 receptor, oral semaglutide can help improve glycemic control and promote weight loss through its effects on appetite regulation and energy expenditure.

One of the key mechanisms of action of oral semaglutide is its ability to slow down the rate at which food moves through the stomach and intestines, leading to increased feelings of fullness and reduced hunger. This delayed gastric emptying can help individuals eat less and make healthier food choices, ultimately leading to a reduction in calorie intake and weight loss. Additionally, oral semaglutide has been shown to decrease food cravings and enhance the body’s response to insulin, making it easier for individuals to control their blood sugar levels and lose weight.

Potential Benefits

Several studies have demonstrated the potential benefits of oral semaglutide for weight loss in individuals with obesity. In a clinical trial involving over 1,900 participants, oral semaglutide was found to significantly reduce body weight and improve various markers of metabolic health compared to a placebo. Participants who took oral semaglutide also experienced improvements in blood sugar control, cholesterol levels, and blood pressure, indicating its potential to help reduce the risk of cardiovascular disease and other obesity-related complications.

In addition to its weight loss benefits, oral semaglutide has been shown to have a favorable safety profile, with relatively few side effects reported in clinical trials. Common side effects of oral semaglutide include nausea, vomiting, and diarrhea, which are usually mild to moderate in severity and tend to improve over time. Serious side effects such as pancreatitis and thyroid tumors are rare but can occur in some individuals, highlighting the importance of careful monitoring and regular follow-up with healthcare providers when using this medication.

Considerations for Use

Before starting treatment with oral semaglutide, individuals should undergo a thorough medical evaluation to assess their overall health status and determine the appropriate dosage and monitoring plan. This medication is typically taken once daily on an empty stomach, at least 30 minutes before the first meal of the day. It is important to follow the dosing instructions provided by a healthcare provider and avoid skipping doses or taking more than the prescribed amount to avoid potential side effects or reduced effectiveness.

Individuals considering oral semaglutide for weight loss should also be aware of potential drug interactions and contraindications that may affect its safety and efficacy. Certain medications, such as oral contraceptives, antibiotics, and antidiabetic agents, can interfere with the absorption or metabolism of oral semaglutide, leading to reduced effectiveness or increased risk of side effects. Additionally, individuals with a history of pancreatitis, thyroid disease, or other serious medical conditions may not be suitable candidates for treatment with oral semaglutide and should consult with a healthcare provider for alternative weight loss options.

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Summary and Frequently Asked Questions

In conclusion, oral semaglutide is a promising medication for weight loss in individuals with obesity, offering multiple benefits for metabolic health and appetite regulation. By targeting the GLP-1 receptor and promoting insulin secretion, oral semaglutide can help individuals achieve and maintain a healthy weight while improving their overall health outcomes. However, it is essential to carefully consider the potential benefits and risks of oral semaglutide before starting treatment and work closely with a healthcare provider to monitor progress and adjust the treatment plan as needed.

Here are some frequently asked questions about oral semaglutide for weight loss:

1. How long does it take to see results with oral semaglutide?

2. What are the common side effects of oral semaglutide?

3. Can oral semaglutide be used in combination with other weight loss medications?

4. Are there any dietary restrictions or lifestyle changes recommended while taking oral semaglutide?

5. What should I do if I miss a dose of oral semaglutide?

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How long does it take to see results on a GLP-1? As a healthcare provider, I get this question all the time—and the answer isn’t one-size-fits-all. In this short video, I break down what you can realistically expect in the first few weeks and months, why slow progress is still progress, and how non-scale victories matter just as much. Whether you’re just getting started or wondering if it’s working fast enough, this is the info you need to stay motivated and informed. Disclaimer: This video is for educational purposes only and does not replace medical advice. Always consult your healthcare provider before making changes to your treatment plan. #glp1journey #glp1support #healthcareprovider #glp1results #glp1timeline #slowandsteady #progressnotperfection #glp1education #metabolichealth #guthealth