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We know they are expensive, but isn’t the cost recouped by the healthcare savings? Dr F. Perry Wilson explains. https://www.medscape.com/viewarticle/glp-1s-are-crazy-effective-just-not-cost-effective-2025a10006es?src=soc_yt --TRANSCRIPT-- Welcome to Impact Factor, your weekly dose of commentary on a new medical study. I’m Dr F. Perry Wilson from the Yale School of Medicine. Much of my time in these videos is spent talking about whether a drug or supplement or diet or intervention works or not. That’s the central focus of medical science: Can we do something for a patient and make a difference in their health? But there’s a related question that we rarely discuss that is almost equally as important: Is this drug or supplement or diet or intervention worth it? And I don’t mean “worth it” in some meta-physical sense. I mean "worth it" in terms of dollars and cents. Is the cost we pay for something worth the benefit we derive from it? I’ll make the argument that the most effective drugs in the past decade are the GLP-1 receptor agonists, drugs like semaglutide and tirzepatide. At least in terms of weight loss, they are truly unparalleled. They are clearly effective. But are they worth it? Are they cost-effective? That is a much harder question, and, as you’ll see in a minute, despite their amazing effects, the answer — for now, at least — is no. How do we decide if a drug is cost-effective? What does that even mean? I’ll give you some extreme examples to illustrate the point a bit. First, for it even to be possible that a drug is cost-effective, it must be effective. It must improve health in some clear, measurable way. Pink jelly beans, while quite inexpensive, do not improve health at all and are therefore not cost-effective. Policymakers should not advocate that insurers cover pink jelly beans. On the flip side are drugs and interventions that actually make money for the system — things that are so good for you, they save money in the long term. The childhood vaccination program is probably the best example of this. The CDC estimates that for every $1 spent on the program, the payer saves about $3 in future costs and society saves about $10 in future costs. This is why insurers have no problem covering childhood vaccines; they would literally be leaving money on the table if they didn’t. So those are the extremes. Don’t pay for pink jelly beans, do pay for vaccines. But we don’t think it is appropriate to cover only stuff that saves money. We are willing to trade money for longer life or quality of life. And this is where the rubber meets the road when it comes to cost-effectiveness analysis: How much is your life worth? To an economist, the answer is basically $100,000 per year of perfect health. The ways they arrive at this number are pretty fascinating, but a lot of it is done by looking at what we as a society are willing to pay for. A cost of $100,000 per “quality-adjusted life year” (QALY) is our standard candle here. More than that is not particularly cost-effective. Less than that is. The “quality” in the QALY is important too. Economists know that a year of perfect health is worth more, in dollar terms, than a year of moderate or poor health. So, if we take an intervention and do some clever modeling based on the price of the intervention and its effectiveness at improving health, we can tell you how much it costs per QALY. Here are a few examples. We have an intervention to pay people to quit smoking. This costs about $2500 per QALY. Seems pretty good. Transcript in its entirety can be found by clicking here: https://www.medscape.com/viewarticle/glp-1s-are-crazy-effective-just-not-cost-effective-2025a10006es?src=soc_yt

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The ketogenic diet has gained popularity in recent years as a way to promote weight loss, improve metabolic health, and boost energy levels. Many people following this diet plan struggle to find convenient snacks that are both tasty and keto-friendly. That’s where Keto Gummies with K3 Spark Mineral come in. These gummies are a delicious and convenient way to get your daily dose of minerals while staying on track with your keto goals.

Benefits of Keto Gummies with K3 Spark Mineral

1. Enhanced Mineral Absorption:

Keto Gummies with K3 Spark Mineral contain a unique blend of essential minerals, including magnesium, potassium, and calcium. These minerals are crucial for maintaining proper hydration, muscle function, and overall health. The K3 Spark Mineral in these gummies helps to enhance the absorption of these minerals, ensuring your body gets the most benefit from them.

2. Supports Ketosis:

Following a ketogenic diet means restricting your carbohydrate intake to promote fat burning and ketone production. Keto Gummies with K3 Spark Mineral are low in carbs and sugar, making them an ideal snack for anyone following a keto diet. The minerals in these gummies also support healthy energy levels and metabolism, helping you stay in ketosis and reach your weight loss goals.

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3. Delicious and Convenient:

One of the biggest challenges of any diet plan is finding snacks that are satisfying and easy to take on the go. Keto Gummies with K3 Spark Mineral are a tasty treat that you can enjoy anywhere, whether you’re at work, at the gym, or traveling. The convenient gummy form makes it easy to get your daily dose of minerals without any hassle.

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1. Snack On-the-Go:

Keep a pack of Keto Gummies with K3 Spark Mineral in your bag or car for a quick and easy snack when you’re feeling hungry. These gummies are a great alternative to traditional sugary snacks and can help satisfy your cravings while providing essential minerals for your body.

2. Post-Workout Recovery:

After a tough workout, your body needs replenishment to help repair muscles and reduce inflammation. Enjoy some Keto Gummies with K3 Spark Mineral to refuel your body with essential minerals and support recovery. The convenient gummy form makes it easy to take these minerals with you to the gym or on a run.

3. Dessert Alternative:

If you have a sweet tooth but want to avoid traditional sugary desserts, Keto Gummies with K3 Spark Mineral are the perfect solution. These gummies are sweetened with stevia and erythritol, making them a delicious treat without any added sugar. Enjoy a few gummies after dinner to satisfy your cravings without derailing your diet.

Key Takeaways

1. Keto Gummies with K3 Spark Mineral are a convenient and delicious way to get essential minerals while following a ketogenic diet.Keto Flo Revolutionizing Your Ketogenic Journey With Advanced Supplements

2. These gummies support energy levels, metabolism, and hydration, making them a valuable addition to your daily routine.

3. Incorporate Keto Gummies into your routine by snacking on-the-go, using them for post-workout recovery, or enjoying them as a dessert alternative.

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