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While looking over the research on the effect of GLP-1 receptor agonists on alcohol consumption, I stumbled across a recent and _really_ interesting paper on how that class of drugs affects sensation. It's "Glp-1 Receptor Agonists Significantly Impair Taste Function" by Rafa Khan and Richard L. Doty in _Physiology & Behavior_ Vol. 291 (published version at https://www.sciencedirect.com/science/article/abs/pii/S003193842400341X and white paper version at https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4953499 ). Don't necessarily take that title on its face, as the details are super important and incredibly interesting and maybe not as dire as you'd think. And, well, I felt like it would be a good use of my platform to discuss all of this. So that's what we're doing today, talking about this hugely consequential new class of drugs - Wegovy/Ozempic (semaglutide), Mounjaro (tirzepatide, although that's also a GIP), and whatever else is going to be out there - with an eye towards spirits nerdery. First I broadly discuss the history and basic mechanisms of these drugs, with a brief detour into side effects and what I would consider to be "best practices" in using them for weight loss purposes. (N.b., I don't get into treatment for type 2 diabetes and that's another set of concerns, also I am not a doctor and please consult a medical professional for all this etc..) And then I discuss the paper above. And... well, it's complicated. Based on their results I think the main takeaway is that while GLP-1 agonists seem to have very good odds of degrading your sense of taste, there's also pretty good odds that you won't actually notice. 🤷 Extra special thanks to my Different Spirits on Patreon (https://www.patreon.com/differentspirits), who got this video first - Eric Amig Anthony Darcy Bean Jamie Brown Kingsbury bushcraft William Christopher Clematis Rob D Liam Davitt Joe Devine Samuel Dose Stephen Eckert eon Ingmar nine Steve Frazee Ian Gendler Solomon Grundy John Halliday Alex Hurd Trevor Jarrait Jonathan Lestingi Kyaru Ariel Mserious Craig Nielsen Jason Newquist No Thanks Chris Rhodes Randy Rice RumSquirrel Gordon W Zach W

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What to expect if you’re trying a GLP-1 weight loss medication. Learn from the healthy 71-lb weight loss success of this busy working mom of 4 who has been using Wegovy combined with daily exercise to lose weight, avoid her family history of diabetes, and maintain the lean muscle mass she needs for a strong, healthy future. Visit https://www.bodi.com for more info. --------------------------------------------------------- One app for all your fitness, nutrition, and healthy mindset needs. Subscribe, stream programs anywhere, and see how our step-by-step approach can help. Sign up for BODi Previews (FREE) to try FREE PREVIEWS of BODi programs: https://bodi.company/43Tj5cQ Apply here to SHARE YOUR STORY on the BODi Experience podcast: https://bit.ly/BODiStory Keep up with the latest BODi Experience Podcast episodes on Apple: https://bodi.company/3wNwk24 Spotify: https://open.spotify.com/show/2FyDmTRHNMC5TtUrBtpe2e or wherever you get your podcasts! SUBSCRIBE to our YouTube channel: https://www.youtube.com/@BODi INSTAGRAM: https://www.instagram.com/bodi/ FACEBOOK: https://www.facebook.com/BODi

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Ozempic and Wegovy: GLP1 agonists and their role in weight loss In this episode, we talk with the wonderful Prof. Giles Yeo on the science behind ✅ Weight loss ✅ Obesity ✅ Nutrition ✅ Diets ✅ and much more

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