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Presentación del Módulo de Diabetes tipo 2 por la Dra Fabiana Vazquez 1 Situación actual - https://youtu.be/Bui5ajQ-2bE 2 Fisiopatología - Diagnóstico - https://youtu.be/uvtc5dQl-CU 3 Objetivos de control metabólico - https://youtu.be/kFVSJEekDSo 4 Tratamiento - https://youtu.be/xe-MHcQBd3U 5 Consenso ADA-EASD - https://youtu.be/W7EhMZVvORo 6 Tratamiento farmacológico de la diabetes tipo 2: Metformina - https://youtu.be/xlGd4IKTzcE 7 Pacientes con o sin enfermedad - https://youtu.be/zHTvmloBT40 8 Intestino: disminución del efecto incretina - https://youtu.be/GOYb9KPJP-w 9 Agonistas del Receptor GLP 1 en la clínica - https://youtu.be/SLH7dQCyszA 10 Inhibidores del cotransportador sodio-glucosa en la clínica - https://youtu.be/1IcTCSnNaaE #diabetes #endocrinología #nutrición

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There has been a lot of excitement in the medical community around the use of semaglutide for weight loss. Semaglutide is a medication originally developed to treat type 2 diabetes, but recent studies have shown that it can also be highly effective in helping people lose weight. However, finding the optimal dose of semaglutide for weight loss can be a complex process. In this article, we will explore the different factors that can impact the ideal dosage of semaglutide, and how healthcare providers can work with patients to find the right amount for their individual needs.

Understanding Semaglutide for Weight Loss

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist, which means that it works by mimicking the effects of a hormone called GLP-1 in the body. GLP-1 is naturally released in response to food consumption and helps regulate blood sugar levels, increase feelings of fullness, and slow down digestion. By acting like GLP-1, semaglutide can help control appetite and promote weight loss.

Studies have shown that semaglutide can lead to significant weight loss in people with obesity, even in the absence of diabetes. In fact, some clinical trials have demonstrated weight loss of up to 15% of initial body weight in participants who took semaglutide. This has made semaglutide an attractive option for people struggling to lose weight through diet and exercise alone.

One of the key benefits of semaglutide for weight loss is its once-weekly dosing schedule. This can make it more convenient for patients compared to other weight loss medications that may require multiple daily doses. However, finding the right dose of semaglutide is crucial to achieving optimal weight loss results while minimizing potential side effects.

Factors Affecting Semaglutide Dosage

There are several factors that can influence the ideal dosage of semaglutide for weight loss. One of the most important considerations is the patient’s starting weight and overall health. People with higher body mass indexes (BMIs) or more severe obesity may require higher doses of semaglutide to achieve significant weight loss.

Another factor to consider is the patient’s response to the medication. Some individuals may experience greater weight loss with lower doses of semaglutide, while others may require higher doses to see results. Healthcare providers will need to monitor patients closely to determine how they are responding to treatment and make adjustments to the dosage as needed.

It is also important to take into account any potential side effects of semaglutide when determining the optimal dose. Common side effects of semaglutide for weight loss can include nausea, vomiting, diarrhea, and constipation. These side effects may be dose-dependent, so finding the right balance between efficacy and tolerability is essential.

Optimizing Semaglutide Dosage for Weight Loss

When starting treatment with semaglutide for weight loss, healthcare providers will typically begin with a lower dose and gradually increase it over time. This allows patients to adjust to the medication and gives providers the opportunity to assess how the patient is responding. The goal is to find the lowest effective dose that produces the desired weight loss results with minimal side effects.

Patients should work closely with their healthcare providers to track their progress and communicate any concerns or changes in symptoms. This can help ensure that the dosage of semaglutide is optimized for each individual’s unique needs. It may take some trial and error to find the right dose, but with patience and perseverance, many patients can achieve significant weight loss with semaglutide.

Conclusion

Semaglutide has shown great promise as a medication for weight loss, with studies demonstrating significant reductions in body weight for many participants. Finding the optimal dose of semaglutide for weight loss can be a nuanced process, influenced by factors such as starting weight, response to treatment, and potential side effects. By working closely with healthcare providers and staying vigilant in monitoring progress, patients can maximize the benefits of semaglutide while minimizing any negative effects. With continued research and clinical experience, semaglutide may prove to be a valuable tool in the fight against obesity and its associated health risks.

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Em todo processo de perda de peso pode ocorrer perda de massa magra, inclusive com o uso de medicamentos como o Wegovy (semaglutida). Para que a proporção de músculo perdido não seja excessivamente grande, é importante que a alimentação tenha quantidades apropriadas de proteínas. Além disso, atividade física regular é fundamental. Referência: Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2021 Mar 18;384(11):989-1002. Informações de contato para agendamentos de consultas presenciais ou por telemedicina no site www.drmateusendocrino.com.br. Não deixe de se inscrever no canal. Compartilhe nossos vídeos com amigos e familiares. Envie seus comentários ou sugestões. Sua participação é muito importante! #endocrinologia #endocrinology #ozempic #wegovy #emagrecimento #emagrecer #semaglutida #músculos #massamagra #massamuscular #sarcopenia

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: Hello, healthcare heroes! The landscape of type 2 diabetes management has been significantly impacted by two powerful injectable medications as per Primary FDA Indication (: Ozempic from Novo Nordisk and Mounjaro from Eli Lilly. Let's break down their differences and strengths. Both Ozempic and Mounjaro are incretin mimetics, leveraging natural gut hormones. • Ozempic® (Semaglutide) is a GLP-1 Receptor Agonist. It mimics Glucagon-Like Peptide-1, helping to lower blood sugar by stimulating insulin release when needed, slowing gastric emptying, and reducing glucagon secretion. Ozempic is available in pre-filled pens that deliver doses of 0.25 mg, 0.5 mg, 1 mg, and 2 mg per injection, with varying solution concentrations. • Mounjaro® (Tirzepatide) takes a unique approach as a dual GLP-1 and GIP Receptor Agonist. By mimicking both GLP-1 and Glucose-Dependent Insulinotropic Polypeptide, it offers potentially more comprehensive effects on blood sugar control. • Mounjaro is available as a subcutaneous injection in pre-filled single-dose pens with strengths of 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, or 15 mg per 0.5 mL. So, how do they stack up in managing type 2 diabetes? • Blood Glucose Control: Mounjaro has shown greater effectiveness at lowering A1C levels compared to Ozempic in clinical trials, attributed to its dual mechanism. For context, the A1C goal for most non-pregnant adults with diabetes is typically less than 7%, though this is always individualized based on patient factors like age, comorbidities, and risk of hypoglycemia. • Weight Loss: While both can lead to weight loss, Mounjaro has demonstrated more significant weight loss in trials, even in type 2 diabetes patients, making it a compelling option for those with co-occurring obesity. • Cardiovascular Protection: Ozempic has established proven cardiovascular benefits, reducing the risk of major adverse cardiovascular events in patients with type 2 diabetes and established cardiovascular disease. Mounjaro's cardiovascular outcomes are currently still being evaluated in dedicated trials Common side effects for both are predominantly gastrointestinal: nausea, vomiting, diarrhea, and constipation. These often improve with time and careful dose titration. Both carry a Boxed Warning regarding the risk of thyroid C-cell tumors, including medullary thyroid carcinoma, observed in rodent studies. They are contraindicated in patients with a personal or family history of MTC or MEN 2 syndrome (which Is a rare genetic polyglandular cancer syndrome. It is characterized by the 100% prevalence of medullary thyroid carcinoma (MTC) Pancreatitis is another serious, rare side effect. The choice between Ozempic and Mounjaro for type 2 diabetes management is highly individualized. It depends on factors like A1C goals which is a key indicator for blood glucose control in individuals with diabetes, weight management needs, cardiovascular risk, tolerability, and patient preferences. Always refer to the latest clinical guidelines and product prescribing information. Sharpen your knowledge, and as we continue exploring modern therapeutics, let's turn our attention to the exciting advancements specifically in chronic weight management... Celagen serves as a vital resource for physicians, nurses, pharmacists, and other allied health professionals seeking to deepen their understanding of advanced therapeutics. Specializing in rapidly evolving fields such as biologics and injectable medications for chronic diseases like obesity and type 2 diabetes, Celagen delivers expertly curated content designed for clarity and clinical relevance. We simplify complex scientific concepts, focusing on mechanisms of action, clinical indications, comparative effectiveness, safety profiles, and strategic considerations for patient management. Through engaging and accessible formats, Celagen aims to support HCPs in making informed decisions and optimizing patient care. #Biologics #Healthcare #MedicalEducation #HCPs #Pharmacology #Immunology #Rheumatology #Oncology #Gastroenterology #Neurology #Dermatology #Biosimilars #Celagen #MedicineExplained

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