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Dr Sarah Barenbaum discusses alternatives to GLP-1 medications for weight loss. https://www.medscape.com/viewarticle/alternatives-glp-1-medications-weight-loss-2025a10007f9?src=soc_yt -- TRANSCRIPT -- Hi. My name is Dr Sarah Barenbaum. Today, I’m going to be talking about alternative weight loss medications other than glucagon-like peptide 1 (GLP-1) receptor agonists. Losing weight and maintaining weight loss are really hard because of biological forces that limit weight loss and promote weight regain over time. Fortunately, for those who qualify, we have FDA-approved medications that can help individuals lose and maintain weight loss. There’s been a large amount of hype more recently about our incretin agonists, often called the GLP-1 receptor agonists, semaglutide and tirzepatide. But these medications are not magic bullets by any means, and they have several limitations. For example, some people do not lose weight with them, or some people cannot tolerate them. And many people don’t have access to them, either due to shortages or restricted insurance coverage and high out-of-pocket costs. This is why it’s important to know there are five other medications that are FDA approved for weight management. These medications are phentermine; orlistat; a combination pill of phentermine and topiramate; a combination pill of bupropion and naltrexone; and liraglutide, which is actually a once-daily GLP-1 receptor agonist. Phentermine is only approved for short-term use or 3-month use. The rest are all approved for long-term use for chronic weight management. If your patient is unable to take a GLP-1 for whatever reason, or if [GLP-1s] are ineffective, consider using one of these other medications, which can also be highly effective in helping patients lose and maintain weight loss. Transcript in its entirety can be found by clicking here: https://www.medscape.com/viewarticle/alternatives-glp-1-medications-weight-loss-2025a10007f9?src=soc_yt

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Oral Semaglutide: A New Frontier in Weight Loss Solutions

In the constant battle against obesity, new weapons are always welcome. One such weapon on the horizon is oral semaglutide, a promising new treatment for weight loss. Semaglutide is already well-known in the medical world for its use in treating type 2 diabetes, but recent studies have shown its potential for weight loss in individuals without diabetes. This new development has sparked excitement among healthcare professionals and patients alike, as it offers a potential solution for the millions of people struggling with obesity.

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The Science Behind Oral Semaglutide

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist, which means it mimics the effects of GLP-1, a hormone produced in the intestines that helps regulate blood sugar levels. By activating the GLP-1 receptor, semaglutide stimulates insulin production, suppresses glucagon secretion, and slows down gastric emptying, all of which contribute to lower blood sugar levels. In the context of weight loss, semaglutide has been shown to reduce food intake by increasing feelings of fullness and reducing cravings, making it easier for individuals to stick to a calorie-controlled diet.

What sets oral semaglutide apart from other weight loss medications is its unique mode of administration. Unlike traditional injectable semaglutide, which is administered via subcutaneous injections, oral semaglutide is taken in pill form. This makes it more convenient and less invasive for patients, potentially increasing adherence to the treatment regimen. In clinical trials, oral semaglutide has demonstrated significant weight loss results, making it a promising option for individuals looking to shed excess pounds.

Another key advantage of oral semaglutide is its safety profile. While all medications come with potential side effects, oral semaglutide has been well-tolerated in clinical trials, with the most common side effects being mild and transient gastrointestinal symptoms such as nausea and diarrhea. This bodes well for its long-term use as a weight loss treatment, as safety and tolerability are crucial considerations for any medication intended for chronic use.

Potential Benefits of Oral Semaglutide

The primary benefit of oral semaglutide is, of course, weight loss. In clinical trials, participants who took oral semaglutide experienced significantly greater weight loss compared to those who took a placebo. This weight loss was sustained over the course of the trial, suggesting that oral semaglutide may be an effective long-term solution for obesity. In addition to weight loss, oral semaglutide has also been shown to improve other metabolic markers, such as blood sugar levels and cholesterol levels, which can have a positive impact on overall health.

As a non-invasive and convenient treatment option, oral semaglutide may also improve patient adherence to the treatment regimen. For individuals who struggle with injections or who have difficulty maintaining a strict medication schedule, the oral formulation of semaglutide offers a simpler and more user-friendly alternative. This can lead to better outcomes in the long run, as consistent use of the medication is essential for achieving and maintaining weight loss goals.

Another potential benefit of oral semaglutide is its versatility. While weight loss is its primary indication, oral semaglutide may also have applications in other areas of health and wellness. For example, some researchers are exploring the use of semaglutide in the treatment of non-alcoholic fatty liver disease (NAFLD), a common complication of obesity. By targeting both weight loss and underlying metabolic dysfunction, oral semaglutide has the potential to address multiple facets of obesity-related health issues.

Considerations for Patients Interested in Oral Semaglutide

Before starting oral semaglutide or any weight loss treatment, it’s important for patients to have realistic expectations and to understand the potential risks and benefits. While oral semaglutide has shown promising results in clinical trials, individual responses to the medication can vary, and not everyone may experience the same degree of weight loss. Additionally, lifestyle factors such as diet and exercise play a crucial role in the success of any weight loss program, including the use of oral semaglutide.

Patients interested in oral semaglutide should also consider the cost of the medication and whether it is covered by their insurance. Weight loss medications are not always fully covered by insurance plans, so out-of-pocket costs can be a significant factor for some individuals. It’s important to discuss these considerations with a healthcare provider to determine the best course of action for each individual’s unique situation.

Overall, oral semaglutide represents a promising new frontier in weight loss solutions, offering a safe, effective, and convenient option for individuals struggling with obesity. As further research is conducted and more real-world data becomes available, oral semaglutide may become an integral part of comprehensive weight loss programs, helping individuals achieve their health and wellness goals.

Summary and Frequently Asked Questions

1. What is oral semaglutide?

Oral semaglutide is a new medication for weight loss that is taken in pill form. It works by mimicking the effects of a hormone called GLP-1, which helps regulate blood sugar levels and reduce food intake.

2. What are the potential benefits of oral semaglutide?

The primary benefit of oral semaglutide is weight loss, with additional improvements in metabolic markers like blood sugar and cholesterol levels. It may also offer a more convenient and user-friendly option for individuals compared to traditional injectable medications.

3. What should patients consider before starting oral semaglutide?

Before starting oral semaglutide, patients should have realistic expectations, understand the potential risks and benefits, and consider factors like cost and insurance coverage. Lifestyle factors such as diet and exercise also play a key role in the success of any weight loss program.

4. Is oral semaglutide safe for long-term use?

While all medications come with potential side effects, oral semaglutide has been well-tolerated in clinical trials, with the most common side effects being mild and transient gastrointestinal symptoms. Its safety profile makes it a promising option for long-term use in the treatment of obesity.

5. What does the future hold for oral semaglutide?

As research continues and more real-world data becomes available, oral semaglutide may become an integral part of comprehensive weight loss programs, helping individuals achieve their health and wellness goals and potentially addressing other health issues related to obesity.