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Even as we prioritize natural interventions in functional medicine, GLP-1 agonist drugs such as Wegovy and Ozempic offer sometimes life-changing support for those who have long struggled with resistant overweight/obesity and high blood sugar. However, there are side effects, including the risk of substantial muscle loss and sagging, aged skin ("Ozempic face" as it's indelicately known). It's a concern that hits home for me, considering the pivotal role we know that muscle plays in overall health and longevity. In this New Frontiers podcast episode I welcome back Dr. Anurag Singh to unravel the complexities of these issues. We explore the interplay between metabolic health and muscle preservation, touching on everything from the mechanisms of GLP-1 agonists and their long-term effects on aging and sarcopenia, to the promising potential of dietary and lifestyle interventions to counteract negative effects. We consider the potential for one of my all-time fave postbiotic epinutrients - Urolithin A - to assist by supporting mitochondrial health and preserving/enhancing muscle quality. This timely conversation is one you won't want to miss. Tune in and please leave us a review wherever you listen to New Frontiers. – DrKF Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for all the relevant links and resources. *Guest information* Anurag Singh, MD, PhD Chief Medical Officer at Timeline *Thank you to our sponsor* Timeline: https://tinyurl.com/4npjcvjf Mitopure: https://tinyurl.com/ypfjws2e Research from Timeline: https://tinyurl.com/53p6yjc9 [email protected] *Timeline Discount for New Frontiers Listeners* Timeline is offering Dr. Fitzgerald’s readers a 10% discount on Timeline products. Head on over to https://tinyurl.com/ypfjws2e and use the code KARA10 at the checkout. *Show Notes* Study: Once-Weekly Semaglutide in Adults with Overweight or Obesity: https://tinyurl.com/y3c2ypkw Pre-clinical trial (Recruiting): Effects of Urolithin A Supplementation on Glucose Metabolism in Healthy Adults 55= Years Old: A Randomized Triple-Masked Controlled Clinical Trial - https://https://tinyurl.com/bdzfccr8 Study: Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults - https://tinyurl.com/2p9pjpxc Study: Antidiabetic Effect of Urolithin A in Cultured L6 Myotubes and Type 2 Diabetic Model KK-Ay/Ta Mice with Glucose Intolerance - https://tinyurl.com/2jkhmu9w Study: Urolithin A, a Gut Metabolite, Improves Insulin Sensitivity Through Augmentation of Mitochondrial Function and Biogenesis - https://tinyurl.com/mvrjxxsm Study: Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults A Randomized Clinical Trial - https://tinyurl.com/fscfdd85 Study: The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans - https://tinyurl.com/mr2hd4ms Study: Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population - https://tinyurl.com/e6npdvyp Preprint article: Topical application of Urolithin A slows intrinsic skin aging and protects from UVB-mediated photodamage: Findings from Randomized Clinical Trials - https://tinyurl.com/2m2nzd56 Preclinical trial: Effects of Mitopure (Urolithin A) on Skeletal Muscle Function, Iron Metabolism and Endurance Performance (ENDURO) - https://tinyurl.com/nhkw2pvc Study: The gut microbiota metabolism of pomegranate or walnut ellagitannins yields two urolithin-metabotypes that correlate with cardiometabolic risk biomarkers: Comparison between normoweight, overweight-obesity and metabolic syndrome - PubMed (nih.gov) - https://tinyurl.com/mrkk33e5 Study: Urolithin A exerts antiobesity effects through enhancing adipose tissue thermogenesis in mice | PLOS Biology - https://tinyurl.com/3s38vtau Study: Urolithin A production drives the effects of pomegranate on the gut microbial metabolism of bile acids and cholesterol in mild dyslipidaemic overweight and obese individuals - PubMed (nih.gov) - https://tinyurl.com/wdzk3tx7 *DrKF Resources* FxMed Podcast: Beyond Mitochondrial Health: Can Urolithin A Slow Down Aging? - https://tinyurl.com/svzahswu DrKF Blog: Beyond Beauty: Targeting Skin Longevity with Urolithin A - https://tinyurl.com/5n6zfu9s DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb Bio Age Lab Test: https://tinyurl.com/b7bjmfj9 Bio Age Self Assessment Quiz: https://tinyurl.com/4z8f7ucc Younger You Group Program: https://tinyurl.com/4hvusavw Younger You book: https://tinyurl.com/mr4d9tym Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw

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Week 16 | Mounjaro Weight Loss Journey | In-Depth Vlog 💉 Hey everyone! Welcome back to another Mounjaro journey update. This week, I’m sharing a longer, more in-depth vlog with you all—hope you enjoy it! 🙌 It’s been a good week overall, with some decent weight loss, but I’m starting to notice the weight loss slowing down a bit, and those cravings are creeping back in. 😅 In this video, I’ll talk about how I’m handling the changes, what’s been working for me, and what I’m adjusting. Plus, I’ll take you along on a fun date day at the zoo with my partner! 🦁🐵 It was a great way to relax and break up the routine while staying focused on the bigger picture. Don’t forget to like, comment, and subscribe for more updates and real talk on this journey. Let me know if you’re dealing with cravings or slowing progress too—I’d love to hear from you! #MounjaroJourney #Week16Update #WeightLossVlog #CravingsAndWeightLoss #DateDayAtTheZoo #WeightLossSlowdown #HealthyLifestyle #WeightLossCommunity #Shane90DayFiance #MounjaroSupport

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Are you on a ketogenic diet and feel like you’re not losing weight? Well if so, Lifeline ACV Keto Gummies might just be what you have been searching for. These gummies are made to facilitate your ketogenic lifestyle by giving the required nutrients for maintaining your nutritional diet and seeing changes. Also, these gummies have a yummy apple cider vinegar taste that will keep you on track as far as your weight loss journey is concerned. This article explores how Lifeline ACV Keto Gummies can be the backbone of all your keto needs.

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It could be difficult to obtain all the necessary minerals and vitamins that are needed while still keeping healthy and active during a Ketogenic Diet. Lifeline ACV Keto Gummies were designed specifically to bring in nutrients necessary for supporting the body’s health on a keto diet. Among other things, these gummies are filled with BHB salts which help initiate ketosis much faster and keeps it alive longer than normal periods. With added Apple Cider Vinegar to help digestion and metabolism, these gummies may work miracles when it comes to weight management.

Perhaps one of the biggest challenges of going keto is staying in ketosis, where instead of carbs the body uses fat as fuel. To stay in ketosis even longer, simply take Lifeline ACV Keto Gummies because they provide exogenous ketones through BHB salts into your system. Thereby, these ketones contribute to maintain this fat burning state making it easier for you reach your weight reduction goals. You can support your ketogenic journey by adding these gummies into daily routine hence make results quicker than ever before.

Delicious and Convenient

Unlike traditional supplements that come in pill form, Lifeline ACV Keto Gummies are delicious treats that you’d actually anticipate taking regularly each day. These gummy bears thus give an easily digestible supplement vehicle unlike those pills or capsules that often get stuck somewhere inside your digestive system. So, when you are feeling down or need more energy on the ketogenic diet, just open up and take a few bites. Whatever life throws at you, these gummies make it easy to stick to your weight loss goals as they are both convenient and portable.

Furthermore, Lifeline ACV Keto Gummies not only taste great but they also use clean ingredients that you can depend on. These gummies are entirely free from any artificial colors or flavors and preservatives whatsoever hence making them the safest option for those embarking on keto diets. When it comes to Lifeline ACV Keto Gummies, quality and purity come in focus since this is a supplement you will love using daily. There’s no more synthetic chemicals but instead pure natural help for your ketogenic needs.

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It does not matter if you have just begun your journey into ketogenesis or if there seems to be a plateau in case of weight loss progress; Lifeline ACV Keto Gummies claim to offer genuine impacts within such situations. Improve your attempts to lose weight by using these gummies which provide essential nutrients required during keto dieting and promote general healthiness of the body. They are truly committed towards providing the best products that achieve results because Lifeline ACV Keto Gummies support weight reduction targets as well as healthy living aspirations the most.

Do not allow the difficulties of this kind of eating lifestyle to come between you and your weight loss targets. In addition, Lifeline ACV Keto Gummies are what you need for a lifetime backup plan in regard to your diet and as a result, get actual results. These gummy bears are made in such a way that they will give your body all the necessary nutrients required to survive on keto diet, making it easier than ever to attain your goals of losing weight. With Lifeline ACV Keto Gummies, forget about withstanding the difficulties associated with dieting and welcome a healthier and happier life.

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Yoga Pilates Reduce Belly Fat #loseweightfast #weightloss #weightlosstips #chestworkout #bellyfatburn #losebellyfat #yogapilates #yoga #exercise #bellyfatburn Disclaimer: "This video uses content that is not owned by me. All credits for the original video go to the rightful creators. My intention is to provide educational or entertainment value by adding my personal touch. If you have any concerns regarding this content, please feel free to contact me."

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