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Source: https://www.podbean.com/eau/pb-bych3-186cf6e Summary: Can Ozempic-like drugs help treat Parkinson’s disease? A new study says no—at least not yet. In this episode, we unpack the results of a major clinical trial that tested exenatide, a GLP-1 drug, in nearly 200 people with Parkinson’s. While earlier research raised hopes, this study found no improvement in symptoms or disease progression. We explore what this means for future treatment strategies, why understanding brain mechanisms is key, and whether other GLP-1 drugs still hold promise. This conversation brings clarity to a complex and evolving area of science. Disclaimer: This podcast is intended for educational and informational purposes only. It does not substitute for professional medical advice, diagnosis, or treatment. Always speak to your healthcare provider before starting or stopping any medications, especially if you have a neurological condition such as Parkinson’s disease. Scientific References & Further Reading: The Lancet. (2024). Exenatide once weekly for 96 weeks in early Parkinson’s disease: A randomized, double-blind, placebo-controlled trial.Parkinson’s Foundation. (2024). Can GLP-1 medications help Parkinson’s disease?Michael J. Fox Foundation. (2024). Exenatide and GLP-1 drug class show mixed results in Parkinson’s research.University of Alabama at Birmingham. Expert commentaries on exenatide and neuroprotection.Nature Reviews Neurology. (2023). Incretin-based therapies in neurodegenerative diseases: Promises and pitfalls.

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The team discusses THC-C8 and the increasing frequency of substance induced psychosis as marijuana and hallucinogens proliferate. Also we explore GLP-1s and the complex realities of losing weight in a world of haters. Pony Up for Mental Health! • Feed a snack to the official ponies of pod therapy! (https://www.patreon.com/therapy/shop/feed-horsey-1573260?utm_medium=clipboard_copy&utm_source=copyLink&utm_campaign=productshare_creator&utm_content=join_link) • Join our Patreon at the Producer level of higher to nominate a name for Emma's new pony! (https://patreon.com/therapy) • Donate a gift Patreon membership to a listener in need! (https://www.patreon.com/therapy/gift) If you are an Apple (https://podcasts.apple.com/us/podcast/pod-therapy/id1330907570) user please rate us! If you are a Spotify (https://open.spotify.com/show/5cQrvuOT3yXZRGoVWP92h6?si=90853105d6464054) user, please rate us! Submit a question (https://forms.gle/vAmD6ZrSdCaV1Xn6A) to the show! Help us reach #1 on Goodpods (https://goodpods.com/podcasts/pod-therapy-84774) ! Listen ad-free, get the show a day early and enjoy the pre-show hang out on the same app you're using RIGHT NOW at www.Patreon.com/Therapy (https://www.patreon.com/Therapy) where you can also access our vast library of deep dives, interviews, skill shares, reviews and rants as well as our live discord chat! Interested in Nick's mental health approach to fitness? Check out www.MentalFitPersonalTraining.com (https://www.mentalfitpersonaltraining.com/) Check out Dr. Jim's book "Dadvice: 50 Fatherly Life Lessons" at www.DadviceBook.com (https://www.dadvicebook.com/) Grab some swag at our store, www.PodTherapyBaitShop.com (https://www.podtherapybaitshop.com/) Play Jim's Neurotic Bingo (https://www.jimsneuroticbingo.com/) at home while you listen to the show, or don't, I'm not your supervisor. Submit questions to: www.PodTherapy.net (https://www.podtherapy.net/) [email protected] Follow us on Social Media: Facebook (https://www.facebook.com/PodTherapy) Instagram (https://www.instagram.com/PodTherapyGuys) Twitter (https://www.twitter.com/PodTherapyGuys) Resources: Suicide Prevention Lifeline - 1-800-273-8255. Veterans Crisis Line - 1-800-273-8255. Substance Abuse & Mental Health Services Administration (SAMHSA) National Helpline - (1-800-662-HELP (4357) OK2Talk Helpline Teen Helpline - 1 (800) 273-TALK U.S. Mental Health Resources Hotline - 211

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This is your reminder that your body can be healthy, strong, and thriving without fitting into someone else’s version of what “fit” should look like. We’re not normalizing being out of shape. We’re not glamorizing extremes. We’re normalizing REAL health. We’re glamorizing effort, strength, and sustainability. If the body you’re building is rooted in discipline, consistency, and self-respect, then you’re on the right track, whether you’re a size 2 or not even close. Don’t shrink to be accepted. Build to be unstoppable, for YOU. Macros: 🍏 Carbs: 31.9g 🍦 Protein: 7.5g 🧈 Fat: 5.5g 🟰 Calories: 232 kcal Recipe: 🍎 Apple Base: 1 medium Gala apple 1/2 tsp ground cinnamon 1/4 tsp ground nutmeg (optional) Pinch of salt Optional: 1/2 tsp monk fruit or stevia sweetener Light spray of coconut oil or melted butter 🥣 Oat Crumble: 2 tbsp old-fashioned oats 1 tsp unsalted butter (melted) 1/2 tsp ground cinnamon Pinch of salt Optional: 1/2 tsp monk fruit or stevia sweetener Bake at 350 for 15-18 mins! Protein Topping Options (choose one): 🍦 2 tbsp high-protein Greek yogurt – OR – 🍦 1 small scoop high-protein ice cream (like Halo Top) for a creamy, dessert vibe Finishing Touch: 🍯 1 tsp honey, drizzled on top of yogurt or ice cream

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Semaglutide is a medication that has gained popularity for its potential as a weight loss treatment. Originally approved for use in treating type 2 diabetes, semaglutide has been found to have significant effects on weight loss. With obesity rates on the rise globally, the search for effective weight loss solutions has become more important than ever. However, like any medical treatment, semaglutide comes with its own set of pros and cons.

Pros of Semaglutide for Weight Loss

Semaglutide has been shown to be highly effective in promoting weight loss. In clinical trials, patients taking semaglutide experienced significant reductions in body weight compared to those taking a placebo. This makes semaglutide a promising option for individuals struggling to lose weight through diet and exercise alone.

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Additionally, semaglutide has been found to have other health benefits beyond weight loss. It has been shown to improve cardiovascular health and reduce the risk of developing type 2 diabetes. This makes semaglutide a valuable treatment option for individuals with obesity-related health issues.

Another advantage of semaglutide is its convenience. The medication is typically administered by injection once a week, making it easy to incorporate into a patient’s routine. This can be especially beneficial for individuals who have trouble remembering to take daily medications or who struggle with adherence to a weight loss plan.

Cons of Semaglutide for Weight Loss

One potential drawback of semaglutide is its cost. The medication can be expensive, especially for individuals without insurance coverage. This cost can be a barrier to access for some patients, limiting their ability to benefit from this treatment option.

Additionally, semaglutide is not without side effects. Common side effects of the medication include nausea, vomiting, and diarrhea. While these side effects are usually mild and temporary, they can still be bothersome for some patients. In rare cases, more serious side effects such as pancreatitis or thyroid tumors may occur.

Another downside of semaglutide is the need for regular monitoring. Patients taking semaglutide may require frequent check-ups and blood tests to monitor their weight loss progress and ensure the medication is working effectively. This can be time-consuming and inconvenient for some patients.

Impact on Quality of Life

Despite the potential benefits of semaglutide for weight loss, its impact on quality of life is an important consideration. For some patients, the positive effects of weight loss may outweigh any negative aspects of taking the medication. However, others may find the side effects or cost to be significant enough to outweigh the potential benefits. It is important for individuals considering semaglutide for weight loss to carefully weigh these factors and consult with their healthcare provider to determine if it is the right treatment option for them.

Long-Term Efficacy

One key question surrounding the use of semaglutide for weight loss is its long-term efficacy. While the medication has been shown to be effective in promoting weight loss in the short term, more research is needed to determine how sustainable these effects are over time. It is possible that patients may regain weight once they stop taking the medication or that the benefits diminish over time. Long-term studies are needed to better understand the potential risks and benefits of semaglutide for weight loss.

Overall Considerations

Ultimately, the decision to use semaglutide for weight loss should be made on an individual basis, taking into account the potential benefits and drawbacks of the medication. It is important for patients to discuss their weight loss goals and concerns with their healthcare provider to determine the best treatment approach for them. While semaglutide shows promise as a weight loss solution, it is not a one-size-fits-all option, and careful consideration should be given to ensure it is the right choice for each patient.