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Breaking News on GLP-1 Medications: Weight Loss, Manufacturing Advances, and Health Benefits In this episode of the Downsized News, hosts Laraine and Christopher Durham dive into the latest breakthroughs and updates on GLP-1 medications, Zepbound, Mounjaro, Ozempic, Wegovy, Compounded tripeptide, and compounded semaglutide. The discussion highlights Eli Lilly's $3 billion investment to ramp up production and reveals new findings on the potential benefits of GLP-1s in reducing dementia risk and improving inflammatory bowel disease outcomes. The duo, having personally lost significant weight with GLP-1s, emphasizes the importance of consulting a healthcare professional before starting any medication. The script also covers Eli Lilly’s manufacturing expansion, the American Diabetes Association's stance on compounded GLP-1s, and promising studies showing GLP-1s' effectiveness in treating obesity and related conditions. Compounded medications' role in healthcare and the potential acquisition of Catalent by Novo Holdings are also discussed, showcasing the vast impact on pharmaceutical manufacturing and patient accessibility. Join the Downsize community as they explore what these developments mean for GLP-1 users. REFERENCES ADA’s Stance on Compounded GLP-1 Medications: A Predictable Take https://diabetesjournals.org/care/article/doi/10.2337/dci24-0091/157478/Compounded-GLP-1-and-Dual-GIP-GLP-1-Receptor IBD Research: https://academic.oup.com/ecco-jcc/advance-article-abstract/doi/10.1093/ecco-jcc/jjae160/7833454?redirectedFrom=fulltext We use Mochi Health: https://joinmochi.com/. Use Laraine’s code for $40 off: QIYGO8. DOWNSIZED WEBSITE: https://thedownsized.org/ JOIN CLUB DOWNSIZED: https://www.youtube.com/@thedownsized/join DOWNSIZED GLP-1 COMPANION PRODUCT STORE: https://thedownsized.org/downsized-store 00:00 Introduction 00:29 Welcome to The Downsized News 00:46 GLP-1 Medications Overview 01:28 Eli Lilly's Big Win with Zepbound 02:54 Eli Lilly's $3 Billion Expansion 06:16 ADA's Stance on Compounded GLP-1s 10:36 GLP-1s and Inflammatory Bowel Disease 13:37 Novo Holdings' New Obesity Treatment 16:28 APC's Fight for Compounded Semaglutide 19:18 Novo Holdings Acquires Catalent 22:59 Conclusion and Wrap-Up

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From Trump's mastery of attention to fashion's new masculinity, exploring January's most thought-provoking cultural signals In this episode, Igor and Johannes kick off 2025 with a new monthly format exploring the media and cultural phenomena that captured their attention. They dive into two key topics that set the tone for the year ahead: First, they examine Chris Hayes and Ezra Klein's conversation about the attention economy and its implications for politics, drawing parallels between U.S. and German political landscapes. The discussion reveals how attention, rather than traditional metrics like fundraising, increasingly shapes political outcomes and cultural discourse. Second, they explore the role of curiosity and informed naivety through the lens of ERL, a Venice Beach fashion brand that offers an alternative approach to masculine aesthetics. This leads to broader reflections on meta-modernism and ways to engage with complex cultural topics beyond pure cynicism or oversimplification. The episode concludes with updates on GLP-1 medications, exploring new research about natural alternatives and emerging evidence about their effects on addiction, bringing fresh perspective to themes from previous seasons. Chapters: 00:00 - Introduction & New Format 02:14 - Attention Economy in Politics 14:45 - ERL & Meta-modernist Approaches 29:22 - GLP-1 Updates & Natural Alternatives 44:51 - Closing Thoughts Links: - Podcast episode with Ezra Klein and Chris Hayes: https://www.nytimes.com/2025/01/17/opinion/ezra-klein-podcast-chris-hayes.html - Erl Website: https://erl.store/ - Systems Magazine interview with Erl founder Eli Russel Linnetz: https://system-magazine.com/issues/issue-18/erl-eli-russell-linnetz-interview-andrew-bolton - Dr. Michael Greger on restoring our natural GLP-1 satiety circuit with fiber (video): https://nutritionfacts.org/video/a-plant-based-diet-for-weight-loss-boosting-glp-1-and-restoring-our-natural-satiety-circuit/ - OZEMPIC: Risks, Benefits, and Natural Alternatives to GLP-1 Weight-Loss Drugs (book) by Michael Greger: https://nutritionfacts.org/book/ozempic/ - Weight Loss Drugs for Curing Addiction? Podcast episode with Chris Hayes and Nicholas Reville: https://podcasts.apple.com/us/podcast/weight-loss-drugs-for-curing-addiction-with-nicholas/id1382983397?i=1000683904777 This episode marks a shift to a new monthly format where Igor and Johannes will reflect on the articles, conversations, and cultural phenomena that shaped their thinking. The discussion weaves together themes of attention economics, cultural aesthetics, and health trends while maintaining the show's focus on helping listeners update their mental models of how the world is changing. You can also listen to this episode on Apple, Spotify or wherever you get your podcasts. Follow the Rabbit on Spotify at https://podcasters.spotify.com/pod/show/follow-the-rabbit Follow the Rabbit on Apple at https://podcasts.apple.com/au/podcast/follow-the-rabbit/id1763655913 Follow the Rabbit on YouTube at https://www.youtube.com/channel/UCXKCXmFazhd1SZxoawCku0w Follow the Rabbit is a Known Unknowns production Known Unknowns on YouTube at https://www.youtube.com/@knownunknowns-xyz Known Unknowns on Instagram at https://www.instagram.com/knownunknowns.xyz/ 📧 Write to us at [email protected] Follow the Rabbit is hosted by Igor Schwarzmann & Johannes Kleske Find out more about Igor Schwarzmann at https://igorschwarzmann.com Find out moire about Johannes Kleske at https://johanneskleske.com

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Belly fat, a common problem where the mid-portion comes bulging out. We all hate it because it stops us from wearing skirts or dresses because the belly portion is too evident. Some foods can help your body burn fat. When you eat these foods, your body is slimming down. The key is to replace the fat-laden foods you would otherwise eat with these fat-burning foods. That way you are doubling your fat-reducing efforts.

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**3 Signs You're NOT in a Calorie Deficit ⬇️** Let’s keep it real: fat loss needs a calorie deficit — there’s no way around it. If you're *trying* to lose weight but not seeing progress, these signs might be the reason why: Tag someone who needs a reality check (with love 😄) 1️⃣ **The Scale Isn’t Moving (for WEEKS)** Not seeing *any* change in your weight for 3-4 weeks? That’s a red flag. Fat loss isn’t instant, but there should be movement over time. If it’s not moving, you're likely eating at or above maintenance. 2️⃣ **You’re “Eating Clean” but Not Tracking Portions** Chicken, oats, peanut butter, dry fruits — healthy doesn’t mean low-calorie. You can overeat “clean food” and still gain weight. Portion control matters more than perfection. 3️⃣ **You’re Always “Waiting Until Monday”** If weekends = eat everything and restart Monday, you’re never truly in a deficit. Consistency intensity. One bad day won’t ruin your progress, but 3 every week definitely will. 4️⃣ **Your Clothes Feel Tighter** Sometimes the scale lies, but your jeans don’t. If they’re getting snug week after week, your body is likely storing more than it’s burning. This journey isn’t about guessing. It’s about *knowing* where you stand. Track your calories, stay consistent, and STOP “restarting” every week. 📩 Comment “CALORIE CALCULATOR” for the free tool that shows you exactly how much to eat 🎯 Share this with someone who’s trying hard but not seeing results!

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With the increasing popularity of the keto diet, more and more people are looking for delicious ways to incorporate this high-fat, low-carb lifestyle into their daily routine. One product that has been gaining attention is keto gummies, especially those endorsed by none other than media mogul Oprah Winfrey. These keto gummies have taken the health and wellness world by storm, offering a tasty and convenient way to stay in ketosis while satisfying your sweet tooth. In this article, we will explore the reasons behind the popularity of keto gummies Oprah endorsed, and why they have become a staple for many keto enthusiasts.

The Rise of Keto Gummies

One of the main reasons why keto gummies have become so popular is their convenience. Unlike traditional keto-friendly snacks that require preparation and refrigeration, keto gummies are portable and easy to eat on the go. This makes them the perfect option for busy individuals who are looking for a quick and satisfying snack that fits within their keto diet. Additionally, the fruity flavors and chewy texture of keto gummies make them a fun and enjoyable treat, unlike some of the more bland and boring keto snacks on the market.

Another factor contributing to the popularity of keto gummies is their versatility. These tasty treats can be enjoyed at any time of day – whether as a mid-morning pick-me-up, an afternoon snack, or a post-dinner dessert. They can also be easily incorporated into meal preps or used as a pre-workout energy boost. With no need for refrigeration, keto gummies are a convenient option for those who are constantly on the move and need a quick and easy snack to keep them satisfied and fueled.

The Oprah Effect

When Oprah Winfrey endorses a product, it is bound to gain widespread attention and popularity. Known for her influence and impact on consumer trends, Oprah’s endorsement of keto gummies has catapulted them into the spotlight and made them a must-have item for those following a keto diet. With her seal of approval, many people trust that these keto gummies are not only delicious but also meet her high standards for quality and taste. This has resulted in a surge in demand for keto gummies and has solidified their place as a staple in the keto community.

Furthermore, Oprah’s endorsement of keto gummies has helped to dispel the misconception that a keto diet is restrictive and boring. By highlighting these delicious and flavorful treats, she has shown that following a keto lifestyle can be enjoyable and satisfying, without sacrificing taste or variety. This has inspired many individuals to explore the world of keto-friendly snacks and has encouraged them to find creative ways to stay on track with their health and wellness goals.

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Why You Should Try Keto Gummies

If you are looking for a tasty and convenient way to stay in ketosis while satisfying your sweet cravings, keto gummies are the perfect option for you. These delicious treats offer a guilt-free indulgence that will not derail your keto diet or leave you feeling deprived. With a wide variety of flavors to choose from, you can find the perfect keto gummies to suit your taste preferences and keep you on track with your health and wellness goals. So why not give them a try and see for yourself why keto gummies Oprah endorsed are the latest craze in the keto community?

Overall, the popularity of keto gummies endorsed by Oprah Winfrey can be attributed to their convenience, versatility, and delicious taste. With Oprah’s stamp of approval, these keto gummies have become a must-have for those following a keto diet, offering a fun and enjoyable way to satisfy their sweet cravings while staying in ketosis. So if you are looking for a tasty and convenient snack to add to your keto meal plan, be sure to give these delicious treats a try and experience the benefits for yourself!