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Oral GLP-1 agonists—like oral semaglutide—are poised to transform the future of obesity and type 2 diabetes treatment. But how close are we to seeing these medications approved and widely available? In this video, we explore the following: How close are we to oral GLP-1s? Will we ever see ozempic and mounjaro tablets? If so, when? Will Eli Lilly, Novo Nordisk or someone else be first to market? Links: Pfizer’s press release discontinuing research on their candidate molecule: https://www.pfizer.com/news/press-release/press-release-detail/pfizer-provides-update-oral-glp-1-receptor-agonist Eli Lilly’s April press release on Orfoglipron https://investor.lilly.com/news-releases/news-release-details/lillys-oral-glp-1-orforglipron-demonstrated-statistically#:~:text=News%20Release-,Lilly's%20oral%20GLP%2D1%2C%20orforglipron%2C%20demonstrated%20statistically%20significant%20efficacy,orforglipron%20worldwide%20without%20supply%20constraints. And their follow-up press release on having these results prublished in the New England Journal of Medicine: https://investor.lilly.com/news-releases/news-release-details/lillys-oral-glp-1-orforglipron-showed-compelling-efficacy-and#:~:text=Lilly's%20oral%20GLP%2D1%2C%20orforglipron,Medicine%20%7C%20Eli%20Lilly%20and%20Company NovoNordisk’s progress as of May 2025: https://www.reuters.com/sustainability/boards-policy-regulation/us-fda-accepts-novo-nordisks-application-oral-wegovy-2025-05-02/ Animal study linking *liraglutide* with thyroid cancer, suggesting it may be species-specific https://academic.oup.com/endo/article-abstract/151/4/1473/2456651?redirectedFrom=fulltext&login=false Timestamps: Timeline for getting a new drug to market [00:28] Who is developing oral GLP-1 agonists? [01:22] Eli Lilly - Orforglipron [02:22] Novo Nordisk - Rybelsus (semaglutide) and NN-9932 [04:42] What else is brewing (“The best of the rest”) [06:11] Okay, so you’ve hear a little something about ozempic, wegovy and the gang, a group of utterly revolutionary large molecules that can help aid in really significant weight loss through a series of injections helping to curb appetite and slow gastric emptying, making you feel fuller for longer, wouldn’t it be neat if this came as a tablet? Eli Lilly and Novo Nordisk think so. Eli Lilly, producer of Mounjaro and Zepbound has one drug in Phase III trials, orforglipron, with results coming out from last month and expected to keep rolling in for the rest of the year and the start of next. After which, we may see it launched as an oral medication for both diabetes and weight loss Novonordisk, already has an oral medication FDA approved but only for the management of diabetes, Rybelsus Eli Lilly have over 6,000 people enrolled in ACHIEVE phase 3 trial that is investigating orforglipron as a diabetes medicine and intend to publish the rest of the data in late 2025 and 2026. They are also running their phase 3 trials investigating its efficacy as a weight management drug under the name ATTAIN and expect to submit to the FDA and other global regulatory bodies before the end of 2025, meaning that if the trials continue to come in with positive results and the FDA are happy, Eli Lilly will be bringing an oral weight loss drug to market around the middle of 2026. as for Novo, they’ve been a lot quieter with their press releases of late Rybelsus, its an oral formulation of Novo Nordisk’s semaglutide molecule, which has proven itself effective time and time again in injection form under brands, Ozempic and Wegovy. Its already out there in the US and Europe and works, though the weight loss effects appear to be about half that of Wegovy. clinical studies have found that increasing the dose increases the weight loss achieved, with one 68-week study finding a 50mg daily oral dose led to 15% weight loss, again, linked down below. the best of the rest: On April 14, Pfizer announced the termination of the development of an attempt at an oral obesity medication after the molecule, named danuglipron, was found to damage the livers of a participant of a phase 2 trial. HRS9531, published their phase 2 trial outcomes in June 2024, finding that, in a study of 249 patients a 6.0mg INJECTION lead to an average weightloss of 16% in just 26 weeks in obese, non-diabetic participants. The phase two trial is linked down below https://diabetesjournals.org/diabetes/article/73/Supplement_1/1861-LB/155203/1861-LB-Efficacy-and-Safety-of-HRS9531-a-Novel Both Eli Lilly and Novo Nordisk are near the final hurdle, so, oral weight loss medications of the GLP-1 agonists may be arrive early 2026. ** All the information contained in this video is not intended nor implied to constitute professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained in this video is for general informational purposes only and does not replace a consultation with your own doctor/health professional **
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Discover the benefits of the new GLP-1 Support Kit, introduced by Dr. Mark Nelson, designed to enhance patient care and improve weight management. Dr. Mark Nelson Contact Info Below: - [email protected] - https://www.optavia.com/us/en/ This updated kit includes Ascend Mini Meals packed with 20 grams of high-quality protein and 5-10 grams of fiber, a Lean and Green Plus Meal, and an Essential Nutrients Pack. Dr. Nelson highlights the critical role of protein in maintaining muscle mass and preventing sarcopenia, alongside the Optimization Kit for additional weight maintenance support. Explore the potential of non-GLP weight loss plans and healthy muscle products. Learn how adopting these programs can not only improve patient outcomes but also help pharmacies boost revenue. Watch now to stay ahead in providing innovative and effective solutions for your patients! Dr. Mark Nelson MD, FACC, MPH, CPT Independent Certified OPTAVIA Coach & Consultant Contact Info: [email protected] Contact Number: 518-573-0608 Download for more info: https://drive.google.com/file/d/1PK4kr3K43rmKsd9Z720YIAAPoexs10Fm/view?usp=sharing https://drive.google.com/file/d/1ns8z4bOcqEJBg5tJpVA4BZtbJogNO8oE/view?usp=sharing Subscribe to our Free Weekly Awesomeness Newsletter: https://diversifyrx.com/weekly-awesomeness-newsletter/ Ask Dr. Lisa Faast your questions by clicking the link below: https://www.drlisafaast.com/ #GLP1SupportKit #PatientCare #WeightManagement #HighProtein #HealthyLiving #PharmacyCare #SarcopeniaPrevention #WeightLossPlans #NutritionSupport #HealthcareInnovation
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In today’s fast-paced world, many people are looking for efficient ways to lose weight and maintain a healthy lifestyle. For some, stimulants may not be the best option due to various reasons such as sensitivity to stimulants, medical conditions, or simply personal preference. Non-stimulant weight loss supplements are a great alternative for those looking to achieve their weight loss goals without the use of stimulants. In this article, we will review some of the best non-stim fat burner options available on the market.
1. Green Tea Extract
Green tea extract is a popular non-stimulant weight loss supplement that is known for its antioxidant properties and ability to boost metabolism. It contains catechins, a type of antioxidant that helps in burning fat. Green tea extract has been shown to increase energy expenditure and fat oxidation, making it an effective supplement for weight loss.
One study found that participants who took green tea extract experienced a significant decrease in body weight and waist circumference compared to those who did not take the supplement. Additionally, green tea extract has been linked to improved heart health and reduced inflammation in the body.
It is important to note that green tea extract should be taken in moderation as excessive consumption can lead to negative side effects such as nausea, vomiting, and liver damage. It is always recommended to consult with a healthcare professional before starting any new supplement regimen.
2. Conjugated Linoleic Acid (CLA)
CLA is another popular non-stimulant weight loss supplement that has been shown to have a positive impact on reducing body fat. It is a type of fatty acid that is naturally found in meat and dairy products. CLA works by increasing the body’s metabolic rate, promoting the breakdown of fat, and inhibiting the production of fat cells.
Several studies have demonstrated the effectiveness of CLA in reducing body fat and improving body composition. One study found that participants who took CLA supplements experienced a significant decrease in body fat mass compared to those who took a placebo. CLA has also been shown to have anti-inflammatory and antioxidant properties.
While CLA is generally considered safe for most people, some individuals may experience digestive issues such as diarrhea, nausea, or stomach discomfort. It is important to follow the recommended dosage guidelines and consult with a healthcare provider before starting a CLA supplement.
3. Garcinia Cambogia
Garcinia cambogia is a tropical fruit that is commonly used in weight loss supplements due to its active ingredient, hydroxycitric acid (HCA). HCA has been shown to block the enzyme citrate lyase, which is responsible for the production of fat in the body. Garcinia cambogia is also believed to suppress appetite and reduce cravings, making it easier to stick to a healthy diet.
Several studies have investigated the effects of garcinia cambogia on weight loss, with mixed results. Some studies have shown a modest decrease in body weight and fat mass, while others have found no significant difference compared to a placebo. It is important to note that more research is needed to determine the full efficacy of garcinia cambogia for weight loss.
When taking garcinia cambogia supplements, it is essential to choose a high-quality product from a reputable manufacturer to ensure safety and effectiveness. Additionally, individuals with medical conditions or taking medications should consult with a healthcare provider before using garcinia cambogia.
4. Acetyl-L-Carnitine
Acetyl-L-carnitine is a naturally occurring amino acid that plays a crucial role in the production of energy in the body. It is often used as a non-stimulant weight loss supplement due to its ability to transport fatty acids into the mitochondria, where they can be converted into energy. Acetyl-L-carnitine has been shown to increase fat metabolism and improve exercise performance.
Several studies have found that acetyl-L-carnitine supplementation can lead to a significant decrease in body weight and fat mass. It has also been linked to improved insulin sensitivity, cognitive function, and muscle recovery. Acetyl-L-carnitine is considered safe for most people when taken in recommended doses.
It is important to note that individual results may vary, and it is essential to follow proper dosage guidelines and consult with a healthcare provider before starting an acetyl-L-carnitine supplement regimen, especially for individuals with pre-existing medical conditions.
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5. Apple Cider Vinegar
Apple cider vinegar has gained popularity in recent years for its potential health benefits, including weight loss. It is rich in acetic acid, which has been shown to reduce fat storage, suppress appetite, and improve metabolism. Apple cider vinegar is also believed to regulate blood sugar levels and promote feelings of fullness.
Several studies have investigated the effects of apple cider vinegar on weight loss, with promising results. One study found that participants who consumed apple cider vinegar daily experienced a significant decrease in body weight, belly fat, and waist circumference. Apple cider vinegar has also been linked to improved digestion and gut health.
While apple cider vinegar is generally safe for most people when consumed in moderate amounts, excessive intake can lead to digestive issues and tooth enamel erosion. It is recommended to dilute apple cider vinegar in water and consume it in moderation as part of a healthy diet and lifestyle.
Summary
Non-stimulant weight loss supplements offer a safe and effective alternative for individuals looking to achieve their weight loss goals without the use of stimulants. Green tea extract, CLA, garcinia cambogia, acetyl-L-carnitine, and apple cider vinegar are just a few of the many non-stimulant options available on the market. These supplements can help boost metabolism, promote fat loss, and support overall health and well-being.
It is essential to choose high-quality products from reputable manufacturers, follow recommended dosage guidelines, and consult with a healthcare provider before starting any new supplement regimen. Incorporating non-stimulant weight loss supplements into a healthy diet and exercise routine can help individuals achieve their desired weight loss results and maintain a healthy lifestyle in the long run.
Remember that weight loss takes time and consistency, so be patient with yourself and stay committed to your health and wellness goals. With the right approach and support, you can achieve your desired weight loss outcomes and improve your overall quality of life.
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