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While resmetirom (Rezdiffra) is currently the only FDA-approved therapy for the treatment of #MASH, findings from a new study suggest GLP-1 RAs may be beneficial in this patient population. “GLP-1 receptor agonists are already FDA-approved for use in diabetes and for obesity. As these are the 2 main risk factors for MASLD and MASH, we're already using these drugs in patients with MASLD and MASH,” A. Sidney Barritt, MD, a professor at the University of North Carolina and director of hepatology at the University of North Carolina Liver Center, explained to HCPLive. “These medications have already been in play in this patient population, so one of the reasons why we did the study that we did is to look and see if these medications actually impact hard measurable outcomes that patients are interested in.” Findings from the analysis of the TARGET-NASH cohort provide real-world evidence suggesting use of these agents is associated with a reduced risk of all-cause mortality and progression from compensated to decompensated MASH cirrhosis. “What this research shows us is that in real-world clinical practice, number 1, we're already using these medications, and number 2, we have a signal here that they will influence these hard patient-important outcomes like symptomatic liver disease, decompensated liver disease, and mortality,” Barritt said. Read more on HCPLive: https://www.hcplive.com/view/a-sidney-barritt-md-real-world-data-suggest-benefit-glp-1-ras-masld #Hepatology #MASLD #LiverDisease

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Obesity is a prevalent health issue affecting millions of people worldwide. It can lead to numerous health complications, including heart disease, diabetes, and even certain types of cancer. Many individuals struggle to lose weight through diet and exercise alone, leading them to seek alternative solutions to help them achieve their weight loss goals. One such solution that has gained popularity in recent years is semaglutide, a medication typically used to treat type 2 diabetes. However, it has also been found to have significant effects on weight loss in clinical trials.

How Does Semaglutide Work for Weight Loss?

Semaglutide belongs to a class of medications known as glucagon-like peptide-1 (GLP-1) receptor agonists. GLP-1 is a hormone produced in the intestines that helps regulate glucose metabolism and insulin secretion. By mimicking the actions of GLP-1, semaglutide can help decrease appetite, increase feelings of fullness, and slow down the emptying of the stomach, leading to reduced food intake and ultimately weight loss.

In addition to its effects on appetite and food intake, semaglutide also has metabolic effects that can contribute to weight loss. It has been shown to improve insulin sensitivity, reduce liver fat, and increase levels of adiponectin, a hormone that helps regulate glucose and fat metabolism. These metabolic effects can further enhance the weight loss benefits of semaglutide.

Furthermore, semaglutide has been found to have beneficial effects on body composition, specifically reducing visceral fat, which is a type of fat stored around the internal organs and is associated with an increased risk of metabolic diseases. By targeting visceral fat, semaglutide can help improve metabolic health and reduce the risk of obesity-related complications.

When Does Semaglutide Start Showing Results for Weight Loss?

One of the key advantages of semaglutide for weight loss is that it typically starts showing results relatively quickly compared to other weight loss medications. In clinical trials, participants taking semaglutide experienced significant weight loss within the first few weeks of starting treatment. Studies have shown that individuals taking semaglutide can expect to lose around 5-10% of their body weight within the first few months of treatment.

The rapid onset of weight loss with semaglutide is thought to be due to its effects on appetite and food intake. By reducing feelings of hunger and increasing feelings of fullness, semaglutide can help individuals eat less and consume fewer calories, leading to immediate weight loss. Additionally, the metabolic effects of semaglutide can also contribute to the early weight loss seen with this medication.

It’s important to note that individual results may vary, and some people may experience more significant weight loss with semaglutide than others. Factors such as diet, exercise, and overall health can influence the effectiveness of semaglutide for weight loss. It’s essential to work closely with a healthcare provider to monitor progress and make any necessary adjustments to ensure the best results.

Are There Any Side Effects of Semaglutide for Weight Loss?

Like any medication, semaglutide can cause side effects, although not everyone will experience them. Common side effects of semaglutide for weight loss include nausea, vomiting, diarrhea, and constipation. These side effects are typically mild to moderate in severity and tend to improve over time as the body adjusts to the medication.





In rare cases, semaglutide can also cause more serious side effects, such as pancreatitis, allergic reactions, and changes in kidney function. It’s essential to be aware of the potential side effects of semaglutide and to seek medical attention if you experience any concerning symptoms while taking the medication.

To minimize the risk of side effects, it’s important to follow your healthcare provider’s instructions carefully and to inform them of any medical conditions or medications you are taking before starting semaglutide. Your healthcare provider can help determine if semaglutide is a safe and appropriate option for you based on your individual health needs.

Can Semaglutide Be Used Long-Term for Weight Loss?

While semaglutide has been shown to be effective for weight loss in the short term, its long-term safety and efficacy for weight management are still being studied. Currently, semaglutide is approved by the FDA for long-term use at a lower dose for the treatment of type 2 diabetes. However, the higher dose typically used for weight loss is considered off-label, meaning it has not been specifically approved for this indication.

Some research suggests that semaglutide can be used long-term for weight management, with continued benefits in terms of weight loss and metabolic health. Studies have shown that individuals who continue taking semaglutide for an extended period can maintain their weight loss and even achieve further reductions in body weight over time.

Ultimately, the decision to use semaglutide long-term for weight loss should be made in consultation with a healthcare provider. They can help assess the risks and benefits of long-term semaglutide use and determine if it is the right option for you based on your individual health goals and needs.

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