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URBANA, Ill. (WCIA) — Drugs like Ozempic, Wegovy and Mounjaro are changing the game for weight loss. GLP-1 medications were originally intended to treat type 2 diabetes, but a growing number of people are using it for weight loss. Patrick Sweeney, University of Illinois molecular and integrated physiology assistant professor, said that while weight loss drugs aren't new, the current medications double or triple the number of pounds shed compared to what was used about a decade ago.

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#drk #medical #medico #diabetes #learnmedical #basicmedical #health #sitagliptin #diabetesdrug #incretins #insulin Sitagliptin is a diabetes drug that works by increasing levels of natural substances called incretins. Incretins help to control blood sugar by increasing insulin release, especially after a meal. They also decrease the amount of sugar your liver makes. What is the mechanism of action of sitagliptin? Sitagliptin increases insulin production and decreases hepatic glucose overproduction. Sitagliptin prolongs the action of GLP-1 and GIP. By enhancing active incretin levels, sitagliptin increases insulin production and lowers glucagon secretion from alpha cells, which decreases hepatic glucose overproduction. How sitagliptin works differently from metformin in the body? Metformin reduces the absorption of sugar from the stomach, reduces the release of stored sugar from the liver, and helps your body use sugar better. Sitagliptin helps to control blood sugar levels by increasing substances in the body that make the pancreas release more insulin. How long does it take for sitagliptin to work? The effect of Januvia (generic name: sitagliptin) on your blood sugar levels may begin quickly, within the first 1 to 2 weeks. You may start to see your blood sugar drop after just a few doses. How does sitagliptin help control blood glucose? It works by increasing the amounts of certain natural substances that lower blood sugar when it is high. Sitagliptin is not used to treat type 1 diabetes (condition in which the body does not produce insulin and therefore cannot control the amount of sugar in the blood) When is the best time to take sitagliptin? You can generally take the tablet at a time of day to suit you, but it is best to take your doses at the same time of day each day. You can take sitagliptin before or after a meal. How sitagliptin works differently from metformin in the body? Metformin reduces the absorption of sugar from the stomach, reduces the release of stored sugar from the liver, and helps your body use sugar better. Sitagliptin helps to control blood sugar levels by increasing substances in the body that make the pancreas release more insulin. How long does it take for sitagliptin to work? The effect of Januvia (generic name: sitagliptin) on your blood sugar levels may begin quickly, within the first 1 to 2 weeks. You may start to see your blood sugar drop after just a few doses. How effective is sitagliptin? Conclusion. In routine clinical practice, sitagliptin produces a significant reduction in mean HbA1c (0.8%) within the first 6 months of use which corresponds to efficacy data obtained in controlled clinical trials.

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