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Investigation on the Effects of GLP1 analog and SGLT2 inhibitor against Diabetic Cardiomyopathy in Type 2 Diabetic Rats: Possible Underlying Mechanisms Background: The present study investigated the possible cardioprotective effects of GLP1 and SGLT2i against diabetic cardiomyopathy (DCM) in type 2 diabetic rats and the possible underlying mechanisms. DCM is defined as the presence of heart failure in absence of coronary artery disease. Methods: Thirty-two male Sprague Dawley rats were randomly subdivided into 4 equal groups; a) control group, b) DM group, type 2 diabetic rats with saline daily for 4 weeks, c) DM+ GLP1, as DM group with GLP1 analogue (liraglutide) at a dose of 75 µg/kg for 4 weeks, and d) DM+ SGLT2i: as DM group with SGLT2 inhibitor (dapagliflozin) at a dose of 1mg/kg for 4 weeks. By the end of treatment (4 weeks), serum blood glucose, HOMA-IR, insulin and cardiac enzymes (LDH, CK-MB) were measured. Also, the cardiac histopathology, myocardial oxidative stress markers (MDA, GSH and CAT) and norepinephrine (NE), myocardial fibrosis, the expression of caspase-3, TGF-, TNF- and tyrosine hydroxylase (TH) in myocardial tissues were measured. Results: T2DM caused significant increase in serum glucose, HOMA-IR, serum CK-MB and LDH (p less than 0.05). Also, DM caused significant myocardial damage and fibrosis, elevation of myocardial MDA, NE with upregulation of myocardial caspase-3, TNF-, TGF- and TH and significant decrease in serum insulin and myocardial GSH and CAT (p less than 0.05). Administration of either GLP1 analog and SGLT2i caused in significant improvement in all studied parameters (p less than 0.05). Conclusion: We concluded that either of GLP1 and SGLT2i exhibited cardioprotective effects against DCM in T2DM with the upper hand for SGLT2i. This might be due to attenuation of fibrosis, oxidative stress, apoptosis (caspase-3), sympathetic nerve activity and inflammatory cytokines (TNF- and TGF-). #type #2 #cardiomyopathy #oxidative #stress #3 #glp1 #norepinephrine #tgf #tnf #and #tyrosine
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How Protein is Good for Weight Loss | High Protein Foods For Fat Loss | Shivangi Desai Protein is not only the building block of all life, but it's also essential for weight loss. Want a customized plan for your health issue? Book your Exclusive One-on-One Health Coaching Session NOW via: ➡https://bit.ly/3R4HhnQ ================================= Achieve your weight loss goals with Satvam Weight Loss Support Supplement Try it now👉🏻👉🏻 https://bit.ly/4ebh1kH 100% organic Boosts metabolism Reduces unwanted fat ================================= Medicine Free Life by Shivangi Desai Book Your Seat Now 👉🏻 https://link.shivangidesai.com/MFL2024 When : 8 PM to 10:30 PM | 21st December 2024 ================================= Health Coach Webinar by Shivangi Desai Book Your Seat Now 👉🏻 https://link.shivangidesai.com/HCW2024 When : 8 PM to 10:30 PM | 23rd December 2024 Want a customized plan for your health issue? Book your Exclusive One-on-One Health Coaching Session NOW via: ➡️https://bit.ly/3R4HhnQ -------------------------------------------- Check out my highest quality protein which I personally use and recommend. Right Human Nutrition👉https://bit.ly/40LVAkk premium quality protein 100% vegetarian We've heard it said that you should eat a high-protein diet to lose weight, but what does that mean? And how do you know what a "high" protein diet is? Protein is the building block for many of your body functions, which is why it's so important. Protein helps to keep you feeling full longer and helps with muscle building. Right Human Nutrition - Get ready to feel your best with our new protein supplements and meal replacement shakes.👉 https://righthumannutrition.com/ They can help you feel fuller after eating just one meal which means you'll be less likely to overeat throughout the day at other meals (which is a good thing!). It also helps build lean muscle mass, which is important for helping your metabolism work properly. And when you're trying to lose weight, you want that metabolism working as efficiently as possible! As long as your body needs the extra energy from the extra calories, it will use them to burn fat instead of storing them. ============ Timestamps: 00:00 - Intro 01:23 - Reason 1 why you should add protein to your diet 03:00 - Reason 2 03:56 - Reason 3 04:45 - Reason 4 05:35 - Reason 5 08:20 - How much protein should be taken in a day 08:49 - High Protein Foods For Fat Loss ============ If you are looking for help in understanding protein, why is it important in your diet, and why it is one of the most important nutrients that we need, then this video is for you. In this video, I'll tell you exactly why proteins are essential for losing weight, which is the top High Protein Foods For Fat Loss, gaining muscle, and feeling good. Do let me know in the comment box what are your thoughts on this video!!👇👇 The Journey To Everest Base Camp 2023 👉👉https://youtu.be/szVLKMZWHmc How To Wake Up Early Without An Alarm | Perfect Your Morning Routine in 4 Steps 👉👉https://youtu.be/1bXPcw64zkk Catch every episode of Holistic Health with Shivangi Desai Podcast 👉👉https://www.youtube.com/playlist?list=PLRzmeH-lIZDLCMo0EK6nUxGWMJHlgCLJf Catch up with me on Spotify: 👉https://open.spotify.com/show/4YbMmNUI3TXCvjSJSSpC9f Fit Bharat Mission is an initiative started by Health Coach Shivangi Desai. Our vision is to spread awareness about Health, Food and Fitness. To get exclusive courses: Join Life Gurukul Application, Install our LifeGurukul app: https://lifegurukul.taplink.ws/ Do you want to connect with Shivangi Desai more frequently? Follow us on: Instagram: https://www.instagram.com/coachshivangidesai/ Facebook: https://www.facebook.com/fitbharatmission Subscribe to us on: YouTube: https://www.youtube.com/c/fitbharatmission . . . #weightloss #shivangidesai #protein #healthcoach #fitbharatmission #fatloss #fitness #nutrition #healthyfood #healthylifestyle #health #food #fit #supplements #healthyeating
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Weight Gain Tips on HOW TO GAIN WEIGHT AND MUSCLE Motivational Video in BANGLA Hindi version of this video: https://youtu.be/gmFyjTLzqt4 English version of this video: Coming Soon Myfitnesspal App link : https://goo.gl/VDiiao If you want to gain weight, then it is very important that you do it right. Binging on soda and donuts may help you gain weight, but it can destroy your health at the same time. If you are underweight, then you want to gain a balanced amount of muscle mass and subcutaneous fat, not a bunch of unhealthy belly fat. There are plenty of normal weight people who get type 2 diabetes, heart disease and other health problems often associated with obesity. Therefore, it is absolutely essential that you still eat healthy foods and live an overall healthy lifestyle. Here are 6 tips to gain weight: 1. Don't drink water before meals. 2. Eat more often 3. Drink milk 4. Use bigger plates 5. Add cream to your coffee 6. Get quality sleep. Our Bengali Channel : youtube.com/jibonsomossarsomadhan Our Hindi Channel : youtube.com/solutionforlifeproblems Our English Channel : youtube.com/sandeepmaheshwarifan Join us on facebook: https://www.facebook.com/SolutionForLifeProblems Follow us on twitter: https://twitter.com/SlutnForLifePrb Video Credits : Animation – Liton Saha Script – Suman Saha Translation – Suman Saha Voiceover – Suman Saha Uploading – Suman Saha Publishing – Suman Saha
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Book your free discovery call *HERE:* https://lastingweightlossnow.com/?source=youtube Struggling to lose weight on Ozempic or other GLP-1 meds? I break down the top 10 diet mistakes that are ruining your weight loss — from undereating to sneaky “healthy” food traps — and shows you exactly what to do instead for real, lasting results. *Costco Ozempic Diet Haul:* https://youtu.be/3MPF-6Rq7TQ?si=tCHD8kC9rSQOvBCa 📍Chapters 0:00 - Intro 1:19 - Mistake #1 - Following “False Hunger” 3:20 - Mistake #2 - Failing to Plan 5:23 - Mistake #3 - Taking an Unsustainable Approach 6:49 - Mistake #4 - Inflamatory Foods 6:33 - Mistake #5 - Healthy Fats 9:01 - Mistake #6 - Protien Quality vs. Quantity 13:07 - Mistake #7 - Drinking Calories 15:30 - Mistake #8 - Digestive Support 17:20 - Mistake #9 - Hydration! 19:18 - Mistake #10 - Outdated “Advice” 21:05 - Bonus Strategy 21:53 - Outro *DISCLAIMER* The content in this video is intended for *educational and informational purposes only* and is *not a substitute for individualized medical advice, diagnosis, or treatment.* Always consult with a qualified, licensed healthcare provider before beginning or modifying any treatment, medication, or wellness program discussed herein. *Dr. Jones and his affiliates expressly disclaim any liability for direct or indirect loss, injury, or damage incurred as a result of reliance on the information presented.* This video may discuss *prescription medications,* including GLP-1 receptor agonists, peptides, and other metabolic therapies, some of which may involve *off-label use, compounded formulations, or investigational drugs* not yet approved by the U.S. Food and Drug Administration (FDA). The inclusion of any compound—whether FDA-approved, compounded under Section 503A of the FD&C Act, or used under state-specific medical discretion—does *not constitute an endorsement, promotion, or medical recommendation.* The legal status of compounded medications may vary by jurisdiction and is subject to change under federal and state law, as well as FDA enforcement discretion. *This content is not intended to advertise or promote any specific drug, product, or provider.* Statements about potential benefits or outcomes are general in nature and *have not been evaluated by the FDA unless otherwise noted.* No guarantees of effectiveness or safety are made, and all therapies discussed should be considered in the context of individual medical oversight. Patient stories, testimonials, before-and-after imagery, or references to clinical results represent *real cases managed by licensed professionals. Individual results vary, and outcomes are not guaranteed.* Where applicable, *patient names, likenesses, voices, or identifying details have been changed or anonymized* in compliance with HIPAA, state privacy laws, and professional ethical guidelines. All patient media is used with *written consent or has* *been sufficiently de-identified* to meet legal standards. *Footage or imagery used may depict real patients or actors and should not be interpreted as typical or universal results.* By viewing this video, you acknowledge that you are voluntarily assuming full responsibility for any personal decisions made based on the content presented. This video is for general public consumption and is *not intended to create a doctor-patient relationship.* For personalized advice or a treatment plan, consult a licensed healthcare provider directly.
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