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Oral GLP-1 agonists—like oral semaglutide—are poised to transform the future of obesity and type 2 diabetes treatment. But how close are we to seeing these medications approved and widely available? In this video, we explore the following: How close are we to oral GLP-1s? Will we ever see ozempic and mounjaro tablets? If so, when? Will Eli Lilly, Novo Nordisk or someone else be first to market? Links: Pfizer’s press release discontinuing research on their candidate molecule: https://www.pfizer.com/news/press-release/press-release-detail/pfizer-provides-update-oral-glp-1-receptor-agonist Eli Lilly’s April press release on Orfoglipron https://investor.lilly.com/news-releases/news-release-details/lillys-oral-glp-1-orforglipron-demonstrated-statistically#:~:text=News%20Release-,Lilly's%20oral%20GLP%2D1%2C%20orforglipron%2C%20demonstrated%20statistically%20significant%20efficacy,orforglipron%20worldwide%20without%20supply%20constraints. And their follow-up press release on having these results prublished in the New England Journal of Medicine: https://investor.lilly.com/news-releases/news-release-details/lillys-oral-glp-1-orforglipron-showed-compelling-efficacy-and#:~:text=Lilly's%20oral%20GLP%2D1%2C%20orforglipron,Medicine%20%7C%20Eli%20Lilly%20and%20Company NovoNordisk’s progress as of May 2025: https://www.reuters.com/sustainability/boards-policy-regulation/us-fda-accepts-novo-nordisks-application-oral-wegovy-2025-05-02/ Animal study linking *liraglutide* with thyroid cancer, suggesting it may be species-specific https://academic.oup.com/endo/article-abstract/151/4/1473/2456651?redirectedFrom=fulltext&login=false Timestamps: Timeline for getting a new drug to market [00:28] Who is developing oral GLP-1 agonists? [01:22] Eli Lilly - Orforglipron [02:22] Novo Nordisk - Rybelsus (semaglutide) and NN-9932 [04:42] What else is brewing (“The best of the rest”) [06:11] Okay, so you’ve hear a little something about ozempic, wegovy and the gang, a group of utterly revolutionary large molecules that can help aid in really significant weight loss through a series of injections helping to curb appetite and slow gastric emptying, making you feel fuller for longer, wouldn’t it be neat if this came as a tablet? Eli Lilly and Novo Nordisk think so. Eli Lilly, producer of Mounjaro and Zepbound has one drug in Phase III trials, orforglipron, with results coming out from last month and expected to keep rolling in for the rest of the year and the start of next. After which, we may see it launched as an oral medication for both diabetes and weight loss Novonordisk, already has an oral medication FDA approved but only for the management of diabetes, Rybelsus Eli Lilly have over 6,000 people enrolled in ACHIEVE phase 3 trial that is investigating orforglipron as a diabetes medicine and intend to publish the rest of the data in late 2025 and 2026. They are also running their phase 3 trials investigating its efficacy as a weight management drug under the name ATTAIN and expect to submit to the FDA and other global regulatory bodies before the end of 2025, meaning that if the trials continue to come in with positive results and the FDA are happy, Eli Lilly will be bringing an oral weight loss drug to market around the middle of 2026. as for Novo, they’ve been a lot quieter with their press releases of late Rybelsus, its an oral formulation of Novo Nordisk’s semaglutide molecule, which has proven itself effective time and time again in injection form under brands, Ozempic and Wegovy. Its already out there in the US and Europe and works, though the weight loss effects appear to be about half that of Wegovy. clinical studies have found that increasing the dose increases the weight loss achieved, with one 68-week study finding a 50mg daily oral dose led to 15% weight loss, again, linked down below. the best of the rest: On April 14, Pfizer announced the termination of the development of an attempt at an oral obesity medication after the molecule, named danuglipron, was found to damage the livers of a participant of a phase 2 trial. HRS9531, published their phase 2 trial outcomes in June 2024, finding that, in a study of 249 patients a 6.0mg INJECTION lead to an average weightloss of 16% in just 26 weeks in obese, non-diabetic participants. The phase two trial is linked down below https://diabetesjournals.org/diabetes/article/73/Supplement_1/1861-LB/155203/1861-LB-Efficacy-and-Safety-of-HRS9531-a-Novel Both Eli Lilly and Novo Nordisk are near the final hurdle, so, oral weight loss medications of the GLP-1 agonists may be arrive early 2026. ** All the information contained in this video is not intended nor implied to constitute professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained in this video is for general informational purposes only and does not replace a consultation with your own doctor/health professional **

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"While these medications can suppress hunger, they may also impact gut health, hormones, muscle mass, skin, hair, nails, and even mental well-being without proper nutritional support. Clinical Dietitian Mitun De Sarkar developed the GLP-1 Diet—a scientifically designed program to help you: Improve metabolic health Preserve muscle and enhance vitality Combat nutrient deficiencies and promote healthy aging Receive fresh, chef-prepared meals delivered to your home This program includes customized meal plans, fitness strategies, and expert guidance to ensure optimal health while using GLP-1 medications. Focus on your journey—we’ll handle the nutrition. 🌱 Take Your Gut Health to the Next Level! 🌱 Looking for more expert insights on digestion, weight loss, and gut healing? ➡️ Visit our website for in-depth guides and personalized wellness tips: SimplyHealthyDiets.com 📸 Follow me on Instagram for daily gut-friendly hacks and motivation: @SimplyHealthyByMitun Let’s unlock the power of a healthy gut together! 💪✨ #GLP1Diet #Ozempic #Mounjaro #Semaglutide #MetabolicHealth #HealthyAging #WeightLoss #GutHealth #HormoneBalance"

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This session was recorded from the live sessions of the 8th National Update on Clinical Diabetes (NUCD), 15-16 January 2022. For more such content, subscribe to our YouTube channel and visit our website www.nucd.in.

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Grüner Tee ist vielleicht eine der gesündesten Getränke, die es gibt. Voller Antioxidantien und anderen nützlichen
Nährstoffen. Es ist daher keine Überraschung, dass grüner Tee oft als Superfood bezeichnet wird und eine Reihe von
gesundheitlichen Vorteilen bietet. Aber wussten Sie, dass grüner Tee auch ein hervorragender Begleiter auf Ihrer
Abnehmreise sein kann?

Die Kraft des Grünen Tees

Grüner Tee ist bekannt für seinen hohen Gehalt an Antioxidantien, insbesondere Epigallocatechingallat (EGCG). Diese
Verbindung ist dafür bekannt, den Stoffwechsel zu steigern und die Fettverbrennung zu fördern. Darüber hinaus kann
grüner Tee auch helfen, den Blutzuckerspiegel zu stabilisieren und das Energieniveau zu erhöhen. All diese
Eigenschaften machen grünen Tee zu einem idealen Begleiter auf Ihrer Abnehmreise.

Grüner Tee als Appetitzügler

Eine Tasse grüner Tee kann auch als natürlicher Appetitzügler dienen. Das in grünem Tee enthaltene Katechin kann
helfen, das Hungergefühl zu reduzieren und somit die Kalorienzufuhr zu verringern. Durch den regelmäßigen Konsum
von grünem Tee können Sie also dazu beitragen, Ihre Ernährung zu kontrollieren und Ihren Gewichtsverlust zu
unterstützen.

Grüner Tee zur Entgiftung des Körpers

Neben seiner Rolle als Abnehmunterstützung kann grüner Tee auch dazu beitragen, Ihren Körper zu entgiften. Die
Antioxidantien im grünen Tee helfen dabei, Giftstoffe und schädliche Substanzen aus Ihrem Körper zu entfernen,
was wiederum zu einer verbesserten Gesundheit und einem gesteigerten Wohlbefinden führen kann. Eine regelmäßige
Entgiftung kann somit Ihren Abnehmprozess fördern und Ihren Körper auf natürliche Weise reinigen.

Grüner Tee als Energiebooster

Wenn Sie auf Ihrer Abnehmreise nach einem natürlichen Energieschub suchen, ist grüner Tee die perfekte Wahl. Der
moderate Koffeingehalt im grünen Tee kann Ihnen helfen, wach und konzentriert zu bleiben, ohne die unerwünschten
Nebenwirkungen von zu viel Koffein zu haben. Darüber hinaus kann grüner Tee auch dazu beitragen, die
Ermüdungserscheinungen zu reduzieren und Ihre körperliche Leistungsfähigkeit zu steigern.

Grüner Tee als Stressabbau

Stress kann oft zu ungesunden Essgewohnheiten führen und somit Ihren Abnehmfortschritt beeinträchtigen. Grüner Tee
enthält jedoch eine Aminosäure namens L-Theanin, die Ihnen helfen kann, Stress abzubauen und gleichzeitig
entspannt und fokussiert zu bleiben. Indem Sie regelmäßig grünen Tee trinken, können Sie Ihren Stress reduzieren
und Ihre Abnehmziele effektiver erreichen.

Zusammenfassung und FAQs

Nachdem Sie nun mehr über die Vorteile von grünem Tee auf Ihrer Abnehmreise erfahren haben, sind Sie vielleicht
neugierig auf einige häufig gestellte Fragen zu diesem Thema. Hier sind einige FAQs, die Ihnen weitere Einblicke
geben können:

1. Wie viel grünen Tee sollte ich täglich trinken, um von seinen gesundheitlichen Vorteilen zu
profitieren?

Es wird empfohlen, etwa 2-3 Tassen grünen Tee pro Tag zu trinken, um von seinen gesundheitlichen Vorteilen zu
profitieren. Achten Sie jedoch darauf, den Konsum zu moderieren, da übermäßiger grüner Teegenuss negativen
Auswirkungen haben kann.

2. Kann grüner Tee tatsächlich beim Abnehmen helfen?

Ja, grüner Tee kann aufgrund seiner Fähigkeit, den Stoffwechsel zu steigern und die Fettverbrennung zu fördern,
tatsächlich beim Abnehmen helfen. Wenn er in Kombination mit einer gesunden Ernährung und regelmäßiger Bewegung
konsumiert wird, kann grüner Tee Ihren Abnehmprozess unterstützen.

3. Gibt es spezielle Sorten oder Marken von grünem Tee, die für den Gewichtsverlust empfohlen
werden?

Es gibt verschiedene Sorten von grünem Tee auf dem Markt, aber am besten ist es, auf Bioqualität und natürlichen
Anbau zu achten. Einige Marken, die für ihre qualitativ hochwertigen grünen Tees bekannt sind, sind zum Beispiel
Matcha Maiden, Sencha Naturals und The Republic of Tea.

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Conclusion

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The company is seeking FDA approval of the drug in 2026.

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