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Drs Piña and Kosiborod discuss semaglutide in obesity-related HF with and without diabetes. Both STEP HFpEF trials show similar HF benefits despite less weight loss in patients with diabetes. https://www.medscape.com/viewarticle/semaglutide-benefits-hfpef-take-step-beyond-weight-loss-2024a10006z2?src=soc_yt -- TRANSCRIPT -- Ileana L. Piña, MD, MPH: Hello, and welcome to my blog. Today, I'm at the American College of Cardiology in Atlanta. I want to introduce and welcome Dr Kosiborod: from the Mid America Heart Institute, who has presented a very impactful paper, STEP HFpEF DM, that is in The New England Journal of Medicine right now. This is about semaglutide. A lot of patients ask me to give them that pill that makes them lose weight. I see primarily patients with heart failure (HF). So, Mikhail, congratulations on your presentation. Give us a little synopsis of what the trial is about. The STEP HFpEF Program Mikhail N. Kosiborod, MD: First of all, it is always a pleasure to be with you. Maybe a quick word about the STEP HFpEF program that included two trials: The first is STEP HFpEF, which was a trial of patients with obesity-related HF with preserved ejection fraction (HFpEF) who did not have diabetes, which we presented and published at European Society of Cardiology in August last year. The second installment of the program is the STEP HFpEF diabetes trial, which is essentially the same population of patients except they also have type 2 diabetes. I guess your question would be why we did two trials instead of just doing one trial that included patients, both with and without diabetes. I'll come back to that shortly. The crux of the hypothesis behind the program is that we all know the prevalence of HFpEF has increased dramatically in the past couple of decades. When I was a fellow in training, it was rare for me to see a patient with HF who had preserved EF. A majority of patients had HF with reduced EF. Now, the majority of people we see have HFpEF: Why did that happen? There are a lot of different reasons for the dramatic change in epidemiology. But certainly, one of them, at least in our opinion, is that the obesity epidemic has a lot to do with it. In fact, if you look at the population of patients with HFpEF in the United States, 80% of them are living with overweight or obesity. The hypothesis behind the program was that obesity is not just a comorbidity. It doesn't just happen to coexist by accident in this patient population, it may in fact be causing their HF. It may be a critical factor in the development and progression of HFpEF. In order to test our hypotheses, patients were randomly assigned to semaglutide, with the target dose of 2.4 mg once a week or matching placebo and treated for 52 weeks, or 1 year. The reason we did two separate trials is because part of that hypothesis was that if obesity is in fact the cause of HF, then certainly, weight loss would be probably not the only factor but "an important factor in the potential benefits of semaglutide in this patient population, provided that semaglutide is beneficial which of course we ultimately demonstrated. But what we knew from weight-loss trials — not HF trials but weight-loss trials of medications like semaglutide and also other anti-obesity medications like tirzepatide and others — is that people with diabetes tend to lose a lot less weight. With these medications, there's about a 40% less weight loss in people with type 2 diabetes. Lots of theoretical reasons why that could be the case. Nobody really knows for sure. We knew from the beginning that the weight loss likely was going to be different. Then, of course, there are other things that happen in people with diabetes: They have more severe HFpEF phenotype, and people with more severe disease sometimes don't respond to treatment the same way as those with less severe disease. Finally, we knew when we started the trial, which was back around 2019, 2020, that people with diabetes would be more likely to be treated with sodium-glucose cotransporter 2 (SGLT2) inhibitors. At the time, we didn't have the data for SLT2 inhibitors in HFpEF, but we knew that were going to be tested. There was, of course, an expectation that they may well be beneficial. For all of these reasons, we said, "You know what, the treatment effects may well be different between the patient population, but let's study them separately." Transcript in its entirety can be found by clicking here: https://www.medscape.com/viewarticle/semaglutide-benefits-hfpef-take-step-beyond-weight-loss-2024a10006z2?src=soc_yt

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Exploring the Keto Diet and Its Popularity in 2025

The ketogenic diet, or keto diet, has gained immense popularity in recent years, particularly as a favored approach to weight loss and improving overall health. As we move into 2025, the use of keto diet gummies has surged, reflecting a significant trend in the dietary supplement industry. These gummies offer a convenient and enjoyable way to help individuals maintain the state of ketosis—a metabolic state where the body burns fat for fuel instead of carbohydrates. The rising demand for these tasty supplements can be attributed not only to their effectiveness but also to the accessibility they provide to those who may find traditional keto dieting challenging.

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In essence, the keto diet involves drastically reducing carbohydrate intake while increasing fat consumption, forcing the body into a state of ketosis. This process can be facilitated by various means, including the use of keto-friendly supplements such as gummies. These products often contain exogenous ketones, which can help elevate blood ketone levels, thus supporting the ketogenic process and assisting users in achieving their weight loss goals more effectively. The current market is filled with an array of options, making it vital for consumers to select high-quality products that can deliver real results.

The appeal of keto gummies lies in their ease of use and the pleasure of consuming a treat that aligns with dietary goals. Unlike traditional methods that may require meticulous meal planning or restrictive eating, gummies provide a delicious way to support one’s keto lifestyle. Furthermore, as people increasingly seek alternatives to conventional weight loss treatments, keto gummies present a viable option. However, not all gummies are created equal, and the effectiveness, ingredient quality, and overall reputation of a brand can vary significantly. In this article, we will delve into the three best keto diet gummies for weight loss in 2025, offering insights into their ingredients, benefits, and customer feedback to guide readers in making informed decisions.

The First Contender: Keto Blast Gummies

Keto Blast Gummies have quickly gained a reputation as one of the top keto products in 2025. These gummies are designed to provide users with an easy and effective way to achieve their keto goals while enjoying a flavorful treat. Comprising a blend of natural ingredients, including exogenous ketones and MCT oil, these gummies work synergistically to promote fat metabolism and maintain ketosis, offering an excellent energy source without the need for excessive carbohydrates.

What sets Keto Blast Gummies apart is not just their premium formulation but also the emphasis on taste and texture. Many users appreciate how these gummies don’t compromise flavor for function, a common pitfall for many health supplements. They come in various flavors that refresh and energize, allowing users to indulge in their cravings without derailing their diet. Additionally, the product’s easy-to-use packaging makes it convenient to carry, making it a suitable option for individuals on the go.

User testimonials frequently highlight the effectiveness of Keto Blast Gummies in helping them achieve weight loss and maintain their energy levels throughout the day. Many individuals report feeling satiated and less tempted by carb-laden snacks, enabling them to stick to their dietary plans more easily. This harmony between taste and efficacy makes Keto Blast Gummies an ideal choice for anyone looking to enhance their weight loss journey without feeling deprived.

Second on the List: Pure Keto Gummies

Pure Keto Gummies have made a significant mark in the world of dietary supplements, offering a clean and effective alternative for those pursuing weight loss through the ketogenic diet. Known for their commitment to high-quality ingredients, Pure Keto Gummies feature a formula devoid of artificial additives, focusing purely on ingredients that promote health and vitality. This dedication to purity is appealing to health-conscious consumers seeking transparency in their dietary choices.

The primary ingredients in Pure Keto Gummies include natural ketones and plant-based extracts known for their fat-burning properties. Each gummy works by providing the body with the necessary support to maintain energy levels and curb cravings, assisting users in adhering to their keto lifestyle. The gummies are also sugar-free, catering to those who need to avoid excess sugar while still enjoying a sweet treat.

<pCustomization options provided by Pure Keto Gummies also add to their allure. They offer various flavors and formulations tailored to different dietary preferences, making it easier for consumers to select a product that perfectly aligns with their lifestyle choices. This flexibility, combined with excellent customer feedback concerning effective weight loss, positions Pure Keto Gummies as a solid contender on the market for keto diet assistance in 2025.

The Third Option: Keto Max Gummies

Keto Max Gummies represent another stellar option in the realm of ketogenic dietary supplements. Offering a robust formulation designed to support rapid weight loss, these gummies feature a blend of high-quality ingredients like BHB (Beta-Hydroxybutyrate) and collagen, which not only aids in maintaining ketosis but also supports muscle health and enhances skin elasticity. This multifaceted benefit makes Keto Max Gummies a unique choice among keto products available in 2025.

What truly makes Keto Max Gummies stand out is their unique approach toward weight management—aside from simply aiding in ketosis, they actively promote healthy metabolic functions. Users have reported not only weight loss but also improved mood and energy levels upon incorporating these gummies into their daily routines. This holistic benefit appeals to consumers looking not just for diet aids, but for supplements that improve overall quality of life.

<pJust like their competitors, Keto Max Gummies prioritize taste, utilizing natural flavorings and sweeteners for a palate-pleasing experience. Many customers have expressed satisfaction with the taste and reported that including these gummies in their diet makes sticking to a ketogenic lifestyle much more enjoyable. Consequently, Keto Max Gummies continue to gain popularity as an effective, delicious addition to the keto diet landscape in 2025.

Analyzing Ingredients and Their Impact

When choosing keto diet gummies for weight loss, understanding the ingredients is crucial to making informed decisions. The effectiveness of these gummies largely hinges on the specific components that comprise their formulations. Ingredients like BHB, MCT oil, and various vitamins play vital roles in how well these products work. BHB, for example, is a ketone body that can significantly enhance the body’s ability to enter and sustain ketosis, ultimately promoting fat burning and energy production.

MCT oil, on the other hand, provides instant energy, making it an excellent fuel source for those following a ketogenic diet. It is quickly absorbed into the bloodstream, allowing for rapid conversion into ketones, which are then utilized for energy. Additionally, some gummies contain added vitamins and minerals that support overall health, including electrolytes to help balance nutrients as the body adapts to a low-carb diet.

<pMoreover, the presence of natural flavorings and sweeteners is essential for ensuring that users enjoy their experience without the guilt that often comes with consuming sugary products. Gummies like Keto Blast and Pure Keto ensure that consumers can satisfy their sweet cravings while staying aligned with their dietary goals. By focusing on clean, natural ingredients, these gummies enhance not only weight loss efforts but also contribute positively to overall health.

Addressing Common Concerns and Misconceptions

The rise of keto diet gummies has prompted various questions and misconceptions about their efficacy and safety. One common concern pertains to the idea that these gummies make it easier to eat whatever one desires without repercussions. While they do facilitate adherence to a ketogenic lifestyle, relying solely on gummies without proper diet management can lead to disappointing results. It is critical to balance gummy intake with a well-rounded, low-carb diet to maximize weight loss potential.

Another frequently asked question soars around the safety and side effects of consuming keto gummies. Most reputable brands ensure that their products are rigorously tested for safety and intake, promoting overall well-being. However, individuals should consult with a healthcare provider before starting any new supplement regimen, especially if they have pre-existing medical conditions or dietary restrictions.

<pAdditionally, many users question whether these gummies truly deliver on their weight loss promises. While individual experiences may vary, the key lies in consistent use paired with a lifestyle that encourages fat burning. Together with healthy food choices and regular exercise, keto diet gummies can indeed help achieve and maintain weight loss goals, making them a worthwhile addition to the arsenal of any keto dieter.

Summary of Key Points and Recommendations

As we conclude this exploration of the best keto diet gummies for weight loss in 2025, it is crucial to summarize the standout products and highlight key considerations for potential users. Keto Blast, Pure Keto, and Keto Max Gummies each provide unique benefits that cater to different preferences and dietary needs. From superior ingredient quality to exceptional taste, these gummies support the ketogenic journey effectively without sacrificing enjoyment.

When selecting a keto gummy, look for those that boast transparency about their ingredients, are free from harmful additives, and have positive user testimonials. It is also beneficial to consult with health professionals to create a holistic plan that incorporates these supplements as part of a broader approach to weight management and health.

<pUltimately, keto diet gummies can be a delightful and effective tool for anyone looking to enhance their ketosis journey. Their combination of great taste, quality ingredients, and supportive action against cravings and energy dips makes them a promising choice for 2025. With the right knowledge and product selection, individuals can take significant strides toward achieving their weight loss goals while enjoying the process.

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