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GLP-1 receptor agonists are now used for the treatment of type 2 diabetes and obesity. Looking back, GLP-1 was found to be a cleavage product of proglucagon processing.A key breakthrough came from the discovery of exendin-4.Exendin-4 is a peptide with agonistic properties at the GLP-1 receptor but resistance to degradation by DPP-4.Semaglutide, the first oral GLP-1 receptor agonist, marked the next milestone. Read more for Medicilon's GLP-1 Drug R&D Platform: https://www.medicilon.com/platform/glp-1/

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Body recomposition, where you build muscle and lose fat at the same time, is typically viewed as "impossible" for natural lifters. It's the "holy grail" when it comes to transformations and can help drastically improve your skinny fat body type and can provide quick results for beginners. And despite popular belief, my personal experience and scientific literature seems to prove that body recomposition is actually more common and feasible than you think. But there's a few steps that you need to follow in order to successfully achieve the results or transformation you're looking for. One of the most important factors is setting up your "body recomposition macros" correctly. Literature suggests that a small caloric deficit combined with a high protein intake provides the best results in terms of a body recomposition. In this video you'll learn more about the optimal body recomposition macros, and I'll provide you with a 3-step protocol that you can use. TAKE THE QUIZ BELOW TO FIND THE BEST SCIENCE-BASED PLAN FOR YOU: https://builtwithscience.com/bws-free-fitness-quiz/gender?utm_source=Youtube&utm_medium=Video&utm_content=Description%20box&utm_campaign=Build%20muscle%20lose%20fat%20simultaneously%20Jan%2025%2F2018 LEAN BULKING VIDEO: https://www.youtube.com/watch?v=ZYJqTNvv1Ys STUDIES: Slow cut: https://www.ncbi.nlm.nih.gov/pubmed/21558571 Protein: https://www.ncbi.nlm.nih.gov/pubmed/28698222 Body recomp (high protein): https://www.ncbi.nlm.nih.gov/pubmed/26817506 https://jissn.biomedcentral.com/articles/10.1186/s12970-015-0100-0 https://www.ncbi.nlm.nih.gov/pubmed/29405780 Athletes/trained individuals recomp: https://www.ncbi.nlm.nih.gov/pubmed/29405780 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411406/ https://journals.lww.com/nsca-jscr/abstract/1990/08000/the_effects_of_self_selection_for_frequency_of.3.aspx MUSIC: https://soundcloud.com/lakeyinspired

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Do you want to look like a celebrity with rock hard abs, shapely hips, and a nice pair of legs? We’ve compiled the best workout routines to help you get there! The process doesn’t happen overnight though. Building a strong and lean core and a well-toned pair of legs means you have to do very specific exercises and eat a low-calorie diet. This workout is a 35-min routine packed with intense exercises that promise to transform your body into your body goals. Good luck and let's start the exercise today!!❤️💪 **If you want to be notified when I upload a new video, make sure to subscribe to our channel. I upload new videos everyday from Sunday to Friday! TIMECODES: 00:00 Introduction 00:37 Kick Back Left 01:24 Rest 01:46 Slow Mountain Climber 02:36 Rest 02:58 Lift Bike Left 03:44 Rest 04:36 Lift Bike Right 05:23 Rest 05:45 Slow Mountain Climber 06:35 Rest 06:57 Lift Bike Right 07:43 Rest 08:40 Ski Jumps 09:20 Rest 09:42 Standing Crunch 10:32 Rest 10:54 Side Lunge Windmill 11:34 Rest 12:26 Ski Jumps 13:06 Rest 13:28 Standing Crunch 14:18 Rest 14:40 Side Lunge Windmill 15:21 Rest 16:18 Floor Taps 16:59 Rest 17:21 Oblique Crunches 18:11 Rest 18:33 Arm Reach Lunge 19:17 Rest 20:09 Floor Taps 20:51 Rest 21:13 Oblique Crunches 22:03 Rest 22:25 Arm Reach Lunge 23:08 Rest 24:05 Walk Downs 24:48 Rest 25:10 Scissor Kicks 26:11 Rest 26:33 Toe Touches 27:13 Rest 28:05 Walk Downs 28:47 Rest 29:09 Scissor Kicks 30:10 Rest 30:32 Toe Touches

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