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PMDD stands for premenstrual dysphoric disorder. This is not to be confused with Premenstrual Syndrome or PMS. PMS is changes in mood during certain parts of the menstrual cycle. It affects 80% of women. The mood changes can be mild to moderate. In fact, some women will just see it as feeling a little moody the week before their menstrual cycle. PMDD is a severe form of PMS. It’s almost like turning into the werewolf when the full moon rises. For some people, it’s just that drastic. It affects 3% - 8% of women. So it’s not as common as PMS. We treat PMDD with antidepressants or hormone therapy. I show you why some women get PMDD and why the antidepressants help. I discuss the difference between intermittent and continuous dosing with antidepressants. I also discuss the two main hormone treatments. If you do not want to take any kind of medication, you can try lifestyle changes. The first are diet modifications such as eliminating caffeine, sugar, nicotine and alcohol and minimizing sodium. You would combine this with sleeping 7-9 hours a night and getting regular exercise – like 3-5 times a week. Some nutritional supplements have shown to be helpful. These would be Calcium 1200mg/day, Vitamin B6 50-100mg/day. Other supplements would be Magnesium 200 – 360mg/day, Vitamin E 400 IU/day. There are some herbal remedies that have been shown in studies to be helpful. Agnus castus fruit extract, also known as chasteberry and Gingko biloba. To download the mood diary go here: http://markspsychiatry.com/mood-diary/ Video on Brain Zaps from medication withdrawal http://www.youtube.com/watch?v=KrcUEarpx-s Want to know more about mental health and self-improvement? On this channel I discuss topics such as bipolar disorder, depression, anxiety disorders, attention deficit disorder (ADHD), relationships and personal development/self-improvement. If you don’t want to miss a video, click here to subscribe. https://goo.gl/DFfT33 References: Article about how SSRI’s increase allopregnalone Griffin LD, Mellon SH. Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes. Proc Natl Acad Sci U S A. 1999;96(23):13512–13517. Bäckström T, Bixo M, et. al. Allopregnanolone and mood disorders. Prog Neurobiol. 2014 Feb; 113:88-94. Epub 2013 Aug 23. Schiller CE, Schmidt PJ, Rubinow DR. Allopregnanolone as a mediator of affective switching in reproductive mood disorders. Psychopharmacology (Berl). 2014;231(17):3557–3567. doi:10.1007/s00213-014-3599-x Griffin LD, Mellon SH. Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes. Proc Natl Acad Sci U S A. 1999;96(23):13512–13517. Khine K, Rosenstein DL, Elin RJ, Niemela JE, Schmidt PJ, Rubinow DR. Magnesium (Mg) retention and mood effects after intravenous Mg infusion in premenstrual dysphoric disorder. Biol Psychiatry. 2006 Feb 15;59(4):327-33. Yonkers KA, Pearlstein TB, Gotman N. A pilot study to compare fluoxetine, calcium, and placebo in the treatment of premenstrual syndrome. J Clin Psychopharmacol. 2013 Oct; 33(5):614-20. Disclaimer: All of the information on this channel is for educational purposes and not intended to be specific/personal medical advice from me to you. Watching the videos or getting answers to comments/question, does not establish a doctor-patient relationship. If you have your own doctor, perhaps these videos can help prepare you for your discussion with your doctor.

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When it comes to weight loss medications, two popular options that are often compared are tirzepatide and semaglutide. Both medications belong to a class of drugs called GLP-1 receptor agonists, which work by mimicking the effects of a hormone called glucagon-like peptide-1 (GLP-1) that is naturally produced in the body. These medications are typically prescribed for people who have obesity or are overweight and have been proven to be effective in helping them lose weight.

Tirzepatide

Tirzepatide is a newer weight loss medication that has been gaining popularity in recent years. It is a once-weekly injection that works by targeting multiple pathways in the body to help regulate blood sugar levels and reduce appetite. Studies have shown that tirzepatide can lead to significant weight loss in people with obesity, making it a promising option for those struggling to lose weight through diet and exercise alone.

One of the key advantages of tirzepatide is its ability to target both weight loss and blood sugar control simultaneously. This can be especially beneficial for individuals with obesity who also have type 2 diabetes, as it can help improve their overall health outcomes. Additionally, tirzepatide has been shown to be well-tolerated in most individuals, with the most common side effects being mild and transient.

However, tirzepatide is not without its drawbacks. Like all medications, it can have potential side effects, including gastrointestinal issues such as nausea and diarrhea. It is also important for individuals taking tirzepatide to have regular check-ups with their healthcare provider to monitor their progress and adjust their dosage as needed.

Semaglutide

Semaglutide is another popular weight loss medication that has been on the market for some time. It is available in both a once-weekly injection and a daily pill form, giving individuals the option to choose the dosing regimen that works best for them. Like tirzepatide, semaglutide works by activating GLP-1 receptors in the body to help regulate blood sugar levels and reduce appetite.

Studies have shown that semaglutide can lead to significant weight loss in individuals with obesity, with some patients losing up to 15% or more of their initial body weight. This has made semaglutide a popular choice for people looking to achieve substantial weight loss goals. In addition to weight loss, semaglutide has also been shown to have other health benefits, such as improving cardiovascular outcomes in individuals with obesity and type 2 diabetes.

While semaglutide is generally well-tolerated, it can also have side effects, such as nausea, vomiting, and constipation. Like tirzepatide, individuals taking semaglutide need to be monitored closely by their healthcare provider to ensure that they are responding well to the medication and to manage any potential side effects that may arise.

Comparing Tirzepatide and Semaglutide

When comparing tirzepatide and semaglutide, it is important to consider the individual needs and preferences of each person. Both medications have been shown to be effective in helping people lose weight, but they may differ in terms of side effects, dosing frequency, and cost. Some individuals may find that one medication works better for them than the other, while others may need to try both to determine which one is the most effective for their weight loss goals.

Ultimately, the decision to use tirzepatide or semaglutide for weight loss should be made in consultation with a healthcare provider who can provide guidance based on an individual’s medical history, current health status, and weight loss goals. Both medications have the potential to help people achieve significant weight loss and improve their overall health outcomes, making them valuable tools in the fight against obesity and overweight.

Whether choosing tirzepatide or semaglutide, it is important for individuals to stay committed to making healthy lifestyle changes, such as following a balanced diet and engaging in regular physical activity, to maximize the benefits of the medication and maintain long-term weight loss success.