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How Do Ozempic and Wegovy Work? Ozempic and Wegovy are synthetic GLP-1 molecules named Semaglutide. Ozempic is approved for type II diabetes mellitus and protection against cardiac events in type II DM patients. Wegovy is approved for weight loss in obese and overweight individuals and for protection against cardiac events in obese and overweight individuals. Let's review the mechanism of action and the side effects of these drugs. If you like this content and want more, click here: https://www.drbeen.com/med-nerd Want to join my uncensored talks? Join me on patreon or substack: Patreon: https://www.patreon.com/mobeensyed?fan_landing=true Substack: https://mobeensyedmd.substack.com/ Want to support this work?: BuyMeACoffee: https://www.buymeacoffee.com/drmobeensyed PayPal: https://paypal.me/mobeensyed?locale.x=en_US #drbeen #koolbeens #Weight_Loss Disclaimer: This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional. FDA Approves First Treatment to Reduce Risk of Serious Heart Problems Specifically in Adults with Obesity or Overweight | FDA https://www.fda.gov/news-events/press-announcements/fda-approves-first-treatment-reduce-risk-serious-heart-problems-specifically-adults-obesity-or Ozempic for weight loss: Does it work, and what do experts recommend? https://health.ucdavis.edu/blog/cultivating-health/ozempic-for-weight-loss-does-it-work-and-what-do-experts-recommend/2023/07 Semaglutide delays 4-hour gastric emptying in women with polycystic ovary syndrome and obesity - PubMed https://pubmed.ncbi.nlm.nih.gov/36511825/ The metabolic role of vagal afferent innervation | Nature Reviews Gastroenterology & Hepatology https://www.nature.com/articles/s41575-018-0062-1 Glucagon-like peptide-1 inhibits gastropancreatic function by inhibiting central parasympathetic outflow | American Journal of Physiology-Gastrointestinal and Liver Physiology https://journals.physiology.org/doi/full/10.1152/ajpgi.1998.275.5.G984 Wegovy® Pen Instructions | Wegovy® (semaglutide) Injection 2.4 mg https://www.wegovy.com/taking-wegovy/how-to-use-the-wegovy-pen.html Incretin https://en.wikipedia.org/wiki/Incretin Glucagon-like peptide-1 inhibits gastric emptying via vagal afferent-mediated central mechanisms - PubMed https://pubmed.ncbi.nlm.nih.gov/9357836/ Give the Receptor a Brake: Slowing Gastric Emptying by GLP-1 | Diabetes | American Diabetes Association https://diabetesjournals.org/diabetes/article/63/2/407/34120/Give-the-Receptor-a-Brake-Slowing-Gastric-Emptying GLP-1 Localisation and Proglucagon Gene Expression in Healthy and Diabetic Mouse Ileum - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200298/#:~:text=For%20instance%2C%20proglucagon%20is%20cleaved,13%2C%2016%2C%2027). What Is an L-Cell and How Do We Study the Secretory Mechanisms of the L-Cell? - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8218725/ Glucagon-Like Peptide-1 Receptor Agonists for Chronic Weight Management - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533252/ Glucagon-like peptide-1 inhibits gastropancreatic function by inhibiting central parasympathetic outflow | American Journal of Physiology-Gastrointestinal and Liver Physiology https://journals.physiology.org/doi/full/10.1152/ajpgi.1998.275.5.G984 Why Ozempic Causes Diarrhea and How to Manage Your Symptoms - GoodRx https://www.goodrx.com/ozempic/diarrhea Wegovy (Semaglutide): Uses, Side Effects & Weight Loss https://www.drugwatch.com/drugs/wegovy/#:~:text=Wegovy%20carries%20a%20black%20box,same%20effects%20occur%20in%20humans. Risk of Gastrointestinal Adverse Events Associated With Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss | Gastroenterology | JAMA | JAMA Network https://jamanetwork.com/journals/jama/fullarticle/2810542 The metabolic role of vagal afferent innervation | Nature Reviews Gastroenterology & Hepatology https://www.nature.com/articles/s41575-018-0062-1 What Is an L-Cell and How Do We Study the Secretory Mechanisms of the L-Cell? - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8218725/ Enteroendocrine cell - Wikipedia https://en.wikipedia.org/wiki/Enteroendocrine_cell#:~:text=in%20the%20duodenum.-,L%20cell,in%20the%20duodenum%20and%20jejunum. What is ilial brake? inslag.indd https://scholarlypublications.universiteitleiden.nl/access/item%3A2956466/view Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483000/#:~:text=Distinct%20neuronal%20cell%20populations%2C%20particularly,glucose%20metabolism%20and%20energy%20expenditure.

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A video summary from the original blog "Exploring GLP-1 Agonist MOA: Key Insights and Therapeutic Potential" published here: https://bmidoctors.com/exploring-glp-1-agonist-moa-key-insights-and-therapeutic-potential/

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Yoga Pilates Reduce Belly Fat #workout #weightlosstips #exercise #weightloss #shorts Disclaimer: "This video uses content that is not owned by me. All credits for the original video go to the rightful creators. My intention is to provide educational or entertainment value by adding my personal touch. If you have any concerns regarding this content, please feel free to contact me."

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Today I’ve got a quick 16-month update on compounded semaglutide – my weight loss progress and the FDA’s changes to the compounding authorization. Here’s the FDA status on concluding the semaglutide shortage that current authorizes compounding pharmacies to make it: https://www.fda.gov/drugs/drug-safety-and-availability/fda-clarifies-policies-compounders-national-glp-1-supply-begins-stabilize Wegovy Direct NovoCare – purchase option for Wegovy (semaglutide) without insurance - https://www.novocare.com/obesity/products/wegovy/get-product.html Lilly Direct purchase option for Zepbound (tirzepatide) without insurance - https://lillydirect.lilly.com/pharmacy/zepbound My semaglutide videos - https://www.youtube.com/playlist?list=PLTStgKmMzWMIB4SjTLAAMV105QvW46SRT The information in this video is for informational and educational purposes only. It is not medical advice and is not intended for the purpose of providing medical or health care advice. This content is not intended to diagnose or treat any health condition, and nothing contained here should be misconstrued as such. Consult with your doctor or qualified health care professional regarding any topics discussed in this video. Article with lots of links to research around GLP-1 drugs: https://open.substack.com/pub/yourlocalepidemiologist/p/curious-about-ozempic-heres-the-lowdown Compounded semaglutide is not without its risks. It is not FDA approved, and in fact, the FDA has warned about shady pharmacies taking shortcuts in production. "Patients should be aware that some products sold as 'semaglutide' may not contain the same active ingredient as FDA-approved semaglutide products and may be the salt formulations. Products containing these salts, such as semaglutide sodium and semaglutide acetate, have not been shown to be safe and effective." FDA Source: https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/medications-containing-semaglutide-marketed-type-2-diabetes-or-weight-loss Shop my Ulta favorites - https://c-linx.com/1nz6V ★ ☆★ ☆★ ☆★ ☆★ Does your skin care routine feel totally random and you can’t tell if it’s working? The fix is simple: plan out your routine and track it. I've made an easy printable planner/tracker worksheet to help you get started! https://skincaretracker.geekoutofwater.com/ Get more behind-the-scenes updates from me over on Patreon: https://www.patreon.com/GeekOutofWater Want more geeky goodness? I send out weekly updates, free samples to help me test recipes, makeup fun, and skin care info by email! Don’t miss out - https://sendfox.com/shelly.hokanson Hang out with fellow beauty lovers in my Facebook group! https://www.facebook.com/groups/goownails ★ ☆★ ☆★ ☆★ ☆★ FOUNDATION & CONCEALER FEST MASTER LISTS! All of the foundations and concealers I’ve reviewed, ranked and searchable: ** UPDATED! ** Foundation – https://foundationfest.softr.app Concealer - https://geekoutofwater.com/concealer-fest/ I’M WEARING: NAILS Wild Unicorn LED Gel nail polish strips by Kleo Kolor https://kleokolor.com/shelly FACE GOOW Bakuchiol Face Cream - https://shopgoow.com/products/bakuchiol-face-cream Merit The Uniform Tinted SPF in shade 26 - https://go.magik.ly/ml/2ch7l/ Merit Great Skin Priming Moisturizer - https://go.magik.ly/ml/2axf2/ Merit Flush Balm in Archival - https://go.magik.ly/ml/2ch7j/ What’s Up Beauty Cheeque Terre Bronzer in Deep - https://bit.ly/41svZ23 EYES MAC Paint Pot in Painterly - https://c-linx.com/L6rrv Natasha Denona I Need a Nude eyeshadow palette - https://c-linx.com/kpjJ9 Merit Clean Lash Mascara - https://go.magik.ly/ml/1qhdx/ Refy Brow Sculpt - https://go.magik.ly/ml/2bt1y/ LIP GOOW Smoothing Lip Treatment - https://shopgoow.com/products/smoothing-lip-treatment CoverGirl Outlast Forever Velvet Pigment in Lava - https://c-linx.com/Non3w or https://go.magik.ly/ml/2ch7r/ MY HANDCRAFTED SKIN CARE - https://bit.ly/goowskin MIXSOON Korean Skin Care – discount with code GEEKOUTOFWATER - https://mixsoon.us/ 10% OFF SCIENCE SERUM TIGHT EYE – code SHELLY - https://shrsl.com/4oz6g NECKNOTZ hand-crafted hemp necklaces by my friend Lindsay - 3% off with code: GOOW https://www.necknotz.com/discount/GOOW BK BEAUTY – awesome cruelty free brushes! get 10% off with code SHELLY10 - https://www.bkbeauty.com/ YESSTYLE – extra discount with code YESGOOW - http://bit.ly/yesgoow ALTER EGO COSMETICS – 10% off with code SHELLY10 - http://bit.ly/alteregoGOOW My Amazon Favorites - http://www.amazon.com/shop/geekoutofwater Snail Mail Shelly Hokanson PO Box 184 McGaheysville VA 22840 Inquiries: [email protected] ABOUT ME: My name is Shelly and I’m a 50-year-old web geek that jumped off the deep end into the makeup and beauty world. I’ve got normal to dry skin, fine lines, and hyperpigmentation caused by sun damage. Cameo appearances by my rescue cats Daffy, Ziva, and Charlie (all girls). FTC: This video is not sponsored.

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