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Sara Ali Khan’s weight loss transformation is nothing short of inspiring. From weighing 96 kg to losing an incredible 45 kg, she’s shown that with determination, proper diet, and the right exercise routine, anything is possible. Let’s take a closer look at Sara's journey and what motivated her to make such a drastic change. #saraalikhan #saraalikhanpataudi #saraalikhanlifestyle #saraalikhannews #saraalikhanworkout #saraalikhanvideo #lifestyle #health #zoom #bollywood ZOOM TV is India's leading Hindi Entertainment news channel that provides the audience with the latest Bollywood updates, breaking news, celebrity and television gossip. It features a vibrant mix of Hindi entertainment and original programming, complemented by current music hits and chart-topping songs. Along with the most recent developments in Bollywood, entertainment highlights, and celebrity scoops, ZOOM TV also features exclusive interviews with Bollywood, Hollywood, and Tollywood celebrities. By giving insights into the K-pop World along with exclusive interviews with Korean celebrities ZOOM TV is your ultimate destination for all things entertainment. Zoom TV also aims to give viewers original and fresh entertainment material through its in-house production section, 'ZOOM STUDIOS,' which develops original shows and series based on intriguing and current themes and formats. Zoom TV is a part of the Times Network, which is owned by The Times Group, India's largest media conglomerate. SUBSCRIBE ► https://www.youtube.com/@zoomtv/ & CLICK On The Bell Icon To Receive All The Latest Updates. Stay Connected With Us On : Facebook - https://www.facebook.com/zoomtv Twitter - https://www.twitter.com/zoomtv Instagram - https://instagram.com/zoomtv/ Website - https://www.zoomtventertainment.com

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#diabetes #weightloss #diabetesdrug Research Reveals Method to Improve Diabetes and Weight-Loss Drug Performance According to new research from the University of Michigan, a network of proteins found in the central nervous system could be leveraged to enhance the effectiveness and minimize the side effects of popular diabetes and weight-loss medications. The study, published in the Journal of Clinical Investigation, focused on two proteins, melanocortin 3 and melanocortin 4, primarily located on the surface of neurons in the brain. These proteins play a central role in regulating feeding behavior and maintaining the body's energy balance.Melanocortin 3 and 4 influence everything from sensing long-term energy stores to processing gut signals about short-term satiety. GLP-1 agonists, such as semaglutides (e.g., Ozempic) and tirzepatides (e.g., Mounjaro), have gained attention for effectively treating type 2 diabetes, obesity, heart disease, and potentially addiction. These drugs mimic a natural hormone produced by the gut when full, signaling the brain to reduce feeding behavior. In the study, researchers tested the effects of several hormones that reduce food intake in the mouse models and discovered that modifying the melanocortin system made mice more responsive to GLP-1 drugs and other hormones influencing feeding behavior. Mice treated with a combination of a GLP-1 drug and an MC4R agonist or MC3R antagonist experienced up to five times more weight loss and reduced feeding compared to those receiving only GLP-1 drugs. The researchers also measured brain activity in areas associated with nausea from GLP-1 drugs and found no increased activation when these drugs were combined with alterations to the melanocortin system. However, priming melanocortin neurons significantly boosted GLP-1 drug activation in hypothalamic feeding centers. The findings suggested that combining GLP-1 drugs with an MC4R agonist could increase the drugs' effectiveness by up to fivefold without enhancing side effects. This approach could allow patients sensitive to side effects to take lower doses or improve outcomes in those unresponsive to current dosages. Further drug development and clinical testing are needed to advance this strategy. Although this research has only been conducted in mouse models, researchers remain optimistic that the results will translate effectively to humans. "The melanocortin system is highly conserved in humans. Everything we've observed in the mouse over the past decades studying these proteins has also been found in humans, so I suspect that these results would also be translatable to patients,” said Cone, director of the U-M Life Sciences Institute Check full updates on Medical Dialogues Also check out - Medical Dialogues Academy, a renowned academic wing of Medical Dialogues - India's premier health and news online portal, proudly presents this comprehensive course tailored for healthcare professionals eager to delve into the realm of medical journalism. 🔗 Enroll Today: https://academy.medicaldialogues.in/courses/certificate-course-in-medical-journalism/ 📚 Explore More With Us: 📌 Medical Content Writing: https://academy.medicaldialogues.in/courses/medical-content-writing/ 📌 Certificate Course in Pharmaceutical Medico-Marketing: https://academy.medicaldialogues.in/courses/certificate-course-in-pharmaceutical-medico-marketing/ Join us on this enlightening journey and become a part of a community pushing the boundaries of healthcare communication and reporting. Get the latest medical and health news at medicaldialogues.in Follow us on Twitter: https://twitter.com/medicaldialogs Facebook: https://www.facebook.com/medicaldialogues/ Instagram: https://www.instagram.com/medicaldialogues LinkedIn: https://www.linkedin.com/company/medical-dialogues Website: https://medicaldialogues.in/

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Amy Schumer is known for her candid humor, and she recently got real with her fans about her experiences with weight loss medications, revealing some surprising differences between two popular drugs—Mounjaro and Ozempic. In an Instagram video with her nearly 13 million followers, the 43-year-old comedian shared her journey of weight loss, from her previous struggles with Ozempic to her newfound success with Mounjaro. Ozempic—A Bad Experience For Schumer, her attempt at weight loss years ago was anything but smooth. She spoke openly about her painful experience with Ozempic, the diabetes drug that gained popularity for its off-label use for weight loss. "I tried it about three years ago," Schumer shared, explaining that she had a severe reaction that left her bedridden. "I was puking, couldn’t handle it... no energy. I lost 30 pounds fast, but honestly, what's the point if you can’t lift your head off the pillow? " Schumer later discovered that her nausea might be linked to her specific genetic makeup—particularly the GDF15 gene, which made her more prone to motion sickness and nausea, exacerbating her reaction to Ozempic. A Better Experience with Mounjaro Fast forward to today, and Schumer's experience with Mounjaro (tirzepatide) has been drastically different.