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Is LDL cholesterol the best way to measure and predict heart disease? New research suggests no! Dave Feldman is an engineer turned citizen scientist who has devoted his life to understanding a phenomenon that some individuals around the world are experiencing: a robust increase in LDL cholesterol while on a ketogenic diet. Dave’s past research has identified a unique phenotype dubbed Lean Mass Hyper-Responders (LMHRs). LMHRs respond to ketogenic therapy with a metabolic profile that includes elevated LDL-C and ApoB levels with otherwise healthy metabolic markers, including low triglycerides, high HDL, low blood pressure, low insulin resistance, and low BMI. In Dave’s most recent publication, what most doctors would consider dangerously high LDL levels in LMHRs did not correlate with an increased risk of heart disease. In this video, Dr. Bret Scher sits down with Dave Feldman to discuss this groundbreaking study and its implications for ketogenic therapy and cardiology. *Key Takeaways:* - LMHRs on a long-term ketogenic diet who show elevated LDL can show robust metabolic health - LDL-C and ApoB were not linked to plaque progression in LMHRs - Existing plaque did predict future plaque accumulation in LMHRs - Individualized approaches to cardiovascular risk assessment are crucial to serve this group better. 🎬 These exciting new findings are featured in Dave Feldman and Jen Isenhart’s  upcoming documentary, *The Cholesterol Code,* the story of how one engineer’s health experiment sparks a global investigation, exposing myths about cholesterol and reshaping our understanding of heart health. Real stories of healing from disease with ketogenic diets provide a blueprint for using food as powerful medicine. Visit [cholesterolcodemovie.com](https://cholesterolcodemovie.com/) to learn more about the film and to be the first to hear about private screenings and the general release in the fall. *Expert Featured:* Dave Feldman CEO, Citizen Science Foundation https://x.com/realDaveFeldman Cholesterol Code website: https://cholesterolcode.com/ *Resources Mentioned:* Coronary Artery Plaque Progression in Asymptomatic Lean Mass Hyper-Responders: A Case Series - https://www.jacc.org/doi/10.1016/j.jacadv.2025.101686 *CMEs Mentioned:* _Managing Major Mental Illness with Dietary Change: The New Science of Hope_ - https://www.mycme.com/courses/managing-major-mental-illness-with-dietary-change-9616 _Brain Energy: The Metabolic Theory of Mental Illness_ - https://www.mycme.com/courses/brain-energy-the-metabolic-theory-of-mental-illness-9615 Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry. Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/ *About us:* Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them. Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications. *Timestamps:* 0:00 - Introduction to Lean Mass Hyper Responders and researcher Dave Feldman. 3:10 - What is the background and setup of Dave’s new Lean Mass Hyper Responder (LMHR) trial? What did the participants’ baseline data look like? 8:00 - What did the 1 year follow up scans show for the participants? Did their elevated LDL & ApoB lead to an increase in plaque buildup? What is the difference between LDL & ApoB? 21:42 - Did the group see an increase in plaque volume and was it rapid? Did anyone see a decrease? What does predict a future increase in plaque if not LDL or ApoB? 26:48 - What causes arterial plaque and what doesn’t cause it? 29:45 - Will Dave Feldman’s study help clinicians and patients accept or continue ketogenic therapy when LDL may be high? 33:09 - What are the limitations to the study and the interpretations to the study? 39:10 - What does Dave Feldman hope a cardiovascular researcher would take away from this study? How does Dave feel about potential pushback from the medical community? 43:45 - Where can people hear more from Dave Feldman and follow his work?

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Join me for my 18th shot of Zepbound as I do my weekly weight loss weigh-in. This was my eighth shot of 7.5 mg. I also discuss a non-scale victory. And I talk about the exhausting effects of radiation therapy for my genetic, incurable Dupuytrene’s Disease aka Viking Disease aka Celtic Disease. I would love to know if anyone else happens to be receiving radiation therapy well on a GLP-1 weight loss medication. The exhaustion has been really unreal and surprising. Thank you for checking my channel out. I hope to see you again! Music from #Uppbeat: https://uppbeat.io/t/brock-hewitt-stories-in-sound/truth License code: UYFNZL6CBU0CAQUS

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Semaglutide, a medication primarily used to treat type 2 diabetes, has recently gained attention for its potential as a weight loss drug. In clinical trials, semaglutide has been shown to be highly effective in helping individuals shed excess pounds when used in conjunction with a reduced-calorie diet and increased physical activity. The drug works by mimicking the effects of a hormone called glucagon-like peptide-1 (GLP-1), which helps regulate blood sugar levels and appetite. This article will explore the reviews of semaglutide for weight loss, its effectiveness, side effects, and whether it may be a suitable option for individuals looking to lose weight.

How Semaglutide Works for Weight Loss

Semaglutide works by activating receptors in the brain that regulate appetite, leading to reduced food intake and, ultimately, weight loss. GLP-1 receptors are found in areas of the brain that control hunger and satiety, so by activating these receptors, semaglutide can help individuals feel full sooner and eat less. Additionally, semaglutide is thought to slow down the emptying of the stomach, which can further contribute to feelings of fullness and reduced calorie intake. These mechanisms make semaglutide a promising option for individuals struggling to lose weight through diet and exercise alone.





One of the key benefits of semaglutide for weight loss is its ability to help individuals maintain their weight loss over the long term. Many people who lose weight end up regaining it over time, but studies have shown that semaglutide can help individuals not only lose weight but also keep it off. This is likely due to the drug’s effects on appetite regulation and food intake, as well as its potential impact on metabolism. By helping individuals achieve sustainable weight loss, semaglutide may be a valuable tool in combating obesity and its associated health risks.

Semaglutide Side Effects

Like any medication, semaglutide can cause side effects, some of which may be mild and temporary, while others may be more serious. Common side effects of semaglutide include nausea, vomiting, diarrhea, and constipation. These side effects typically subside over time as the body adjusts to the medication, but they can be bothersome for some individuals. In rare cases, semaglutide may cause more serious side effects such as pancreatitis, gallbladder problems, or allergic reactions. It is important to discuss the potential risks and benefits of semaglutide with a healthcare provider before starting treatment.

Individuals considering semaglutide for weight loss should be aware of the potential risks and benefits of the medication and work closely with their healthcare provider to monitor their progress and adjust their treatment plan as needed. While semaglutide may be an effective option for some individuals, it is not suitable for everyone, and it is important to weigh the potential benefits against the potential risks before deciding to start treatment. By being informed and proactive, individuals can make the best decision for their weight loss journey and overall health.

Is Semaglutide Right for You?

Before considering semaglutide for weight loss, it is important to consult with a healthcare provider to discuss your individual health needs and goals. Semaglutide is typically prescribed for individuals with a body mass index (BMI) of 27 or higher who have obesity-related health conditions such as type 2 diabetes or high blood pressure. Additionally, individuals should have tried other weight loss methods, such as diet and exercise, without success before considering semaglutide as a treatment option. Your healthcare provider can help determine if semaglutide is a suitable choice for you based on your medical history, current health status, and weight loss goals.

Overall, semaglutide shows promise as a weight loss medication for individuals struggling to lose weight through traditional methods. By working with a healthcare provider to assess your individual needs and risks, you can determine if semaglutide is a suitable option for you. With its proven effectiveness, ability to maintain weight loss, and potential impact on appetite regulation, semaglutide may be a valuable tool for individuals looking to achieve long-term weight loss and improve their overall health.

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Recent headlines have been buzzing about Oprah Winfrey’s endorsement of the popular ketogenic diet. The media mogul has credited the low-carb, high-fat eating plan for helping her shed pounds and feel better than ever. But what exactly is the keto diet, and is it really as effective as it’s made out to be? In this article, we’ll dive deep into the world of Oprah and keto to unveil the truth behind this diet trend.

Understanding the Keto Diet

The ketogenic diet, commonly known as keto, is a high-fat, low-carb eating plan that forces the body to burn fat for energy instead of carbohydrates. By drastically reducing your carb intake and increasing your fat consumption, your body enters a state of ketosis where it produces ketones for fuel. This can lead to rapid weight loss and other health benefits, such as improved blood sugar control and increased energy levels.

Many people turn to the keto diet as a way to lose weight quickly and efficiently. By cutting out carbs and focusing on consuming healthy fats, protein, and vegetables, followers of the keto diet may experience significant changes in their body composition and overall well-being. However, it’s important to note that the keto diet is not suitable for everyone, and consulting with a healthcare professional before starting any new diet plan is always recommended.

One of the key principles of the keto diet is to limit your carb intake to around 20-50 grams per day. This can be challenging for some people, especially those used to consuming a diet high in carbohydrates. Foods such as bread, pasta, sugar, and starchy vegetables are off-limits on the keto diet, while healthy fats like avocado, olive oil, and nuts are encouraged. Meal planning and preparation are essential when following the keto diet to ensure you’re getting the right balance of nutrients.

Oprah’s Journey with Keto

Oprah Winfrey, a well-known advocate for health and wellness, has publicly shared her experience with the keto diet. In a recent interview, Oprah revealed that she had tried the keto diet and found it to be effective in helping her lose weight and improve her overall health. She credited the diet for giving her more energy and helping her feel more focused throughout the day.

Like many others, Oprah faced challenges when first starting the keto diet, as it required her to make significant changes to her typical eating habits. However, with dedication and commitment, Oprah was able to adapt to the keto lifestyle and see positive results. She emphasized the importance of listening to your body and making adjustments as needed to find what works best for you on the keto diet.

While Oprah’s success with the keto diet has inspired many to give it a try, it’s essential to remember that what works for one person may not work for another. Each individual’s body is unique, and finding the right balance of macronutrients and calories on the keto diet is key to achieving success. If you’re considering trying the keto diet, it’s best to consult with a healthcare provider or nutritionist to create a personalized plan that meets your specific needs and goals.

Debunking Keto Myths

Despite its growing popularity, the keto diet has faced its fair share of criticism and skepticism. Some believe that the high-fat nature of the diet could increase cholesterol levels and risk of heart disease, while others worry about the lack of fiber and essential nutrients in the absence of certain foods. However, research has shown that the keto diet can be safe and effective when followed correctly and under the supervision of a healthcare professional.

Another common misconception about the keto diet is that it’s only suitable for short-term weight loss and isn’t sustainable in the long run. While some people may use the keto diet as a way to kickstart their weight loss journey, others choose to adopt it as a long-term lifestyle change. With careful planning and a focus on nutrient-dense foods, it’s possible to follow the keto diet in a healthy and sustainable way.

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As with any diet trend, it’s important to approach the keto diet with caution and awareness of your body’s needs. While many have experienced success with the keto diet, others may find it challenging to maintain over time. It’s crucial to listen to your body, monitor your progress, and seek guidance from healthcare professionals to ensure you’re getting the most out of the keto diet while staying safe and healthy.

Final Thoughts on Oprah and Keto

As Oprah Winfrey continues to inspire others with her weight loss journey and commitment to health and wellness, her endorsement of the keto diet has sparked curiosity and interest in this popular eating plan. While the keto diet may not be suitable for everyone, it has proven to be effective for many in achieving their weight loss and health goals.

Whether you’re considering trying the keto diet for yourself or simply curious about Oprah’s experience with it, it’s essential to approach any dietary changes with caution and awareness. Consult with a healthcare provider or nutritionist to determine if the keto diet is right for you and create a personalized plan that aligns with your individual needs and goals.

Remember, there is no one-size-fits-all approach to diet and nutrition, and what works for one person may not work for another. Stay informed, listen to your body, and make decisions that support your overall health and well-being on your journey to a healthier lifestyle.

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